PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16470913-3	2006	RESULTS: In the dose-effect study, soybean isoflavone, luteolin and curcumin induced the CYP3A4 transcription via PXR in an evident dose-dependent manner, but isorhamnetin and rutin did not.	Luteolin	55-63	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	89-95	
31720444-7	2019	Six phytochemicals (Geranin, Apigenin, Fisetin, Luteolin, Phthalic acid and Gallic acid) were predicted to be inhibitors of CYP3A4 and, may slowdown elimination of PIs thereby maintain optimal PIs concentrations.	Luteolin	48-56	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	124-130	
18191104-3	2008	Both diosmetin and luteolin decreased 1"-OH-MDZ formation by human recombinant CYP3A4, but not CYP3A5, whereas they decreased 4-OH-MDZ formation by both recombinant enzymes.	Luteolin	19-27	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	79-85	
16470913-5	2006	In the time-effect study, 10 micromol/L and 50 micromol/L soybean isoflavone, luteolin and curcumin induced CYP3A4 transcription between 12 h and 48 h, the strongest induction appeared in 48 h. 48 h after induction, 50 micromol/L soybean isoflavone, luteolin and curcumin exhibited a 6.72-fold, 3.24-fold, and 2.13-fold increase respectively, compared with 0.1% DMSO treated cells.	Luteolin	78-86	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	108-114	
16470913-5	2006	In the time-effect study, 10 micromol/L and 50 micromol/L soybean isoflavone, luteolin and curcumin induced CYP3A4 transcription between 12 h and 48 h, the strongest induction appeared in 48 h. 48 h after induction, 50 micromol/L soybean isoflavone, luteolin and curcumin exhibited a 6.72-fold, 3.24-fold, and 2.13-fold increase respectively, compared with 0.1% DMSO treated cells.	Luteolin	250-258	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	108-114	
16470913-6	2006	CONCLUSION: Three phytochemicals, i.e. soybean isoflavone, luteolin and curcumin stimulate the PXR-mediated transcription of CYP3A4.	Luteolin	59-67	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	125-131