PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34439516-11	2021	Our results indicated that LUTN effectively alleviated AFB1-induced liver injury, and the underlying mechanisms were associated with the activation of the Nrf2 signaling pathway.	Luteolin	27-31	nuclear factor, erythroid derived 2, like 2	Mus musculus	155-159	
34439516-0	2021	Luteolin Alleviates AflatoxinB1-Induced Apoptosis and Oxidative Stress in the Liver of Mice through Activation of Nrf2 Signaling Pathway.	Luteolin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	114-118	
24361407-0	2014	Luteolin and luteolin-7-O-glucoside strengthen antioxidative potential through the modulation of Nrf2/MAPK mediated HO-1 signaling cascade in RAW 264.7 cells.	Luteolin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	97-101	
32271832-0	2020	Low dose of luteolin activates Nrf2 in the liver of mice at start of the active phase but not that of the inactive phase.	Luteolin	12-20	nuclear factor, erythroid derived 2, like 2	Mus musculus	31-35	
32271832-2	2020	Several studies reported that high dose of luteolin activates the Nrf2/ARE pathway in the liver.	Luteolin	43-51	nuclear factor, erythroid derived 2, like 2	Mus musculus	66-70	
30977402-7	2019	Furthermore, tert-butylhydroquinone triggered the overexpression of Nrf2 to reduce ER stress, but luteolin inhibited Nrf2 nuclear localization to elevate ER stress.	Luteolin	98-106	nuclear factor, erythroid derived 2, like 2	Mus musculus	117-121	
24642087-7	2014	Moreover, luteolin enhanced the translocation of Nrf2 to the nucleus both in vivo and in vitro, which was proved by the results of Western blot, immunohistochemistry, and electrophoretic mobility shift assay (EMSA).	Luteolin	10-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	49-53	
26205695-0	2015	Therapeutic potential of digitoflavone on diabetic nephropathy: nuclear factor erythroid 2-related factor 2-dependent anti-oxidant and anti-inflammatory effect.	Luteolin	25-38	nuclear factor, erythroid derived 2, like 2	Mus musculus	64-107	
26205695-4	2015	In the present study, we evaluated the Nrf2-dependent anti-oxidative and anti-inflammatory effects of digitoflavone in streptozotocin-induced diabetic nephropathy.	Luteolin	102-115	nuclear factor, erythroid derived 2, like 2	Mus musculus	39-43	
26205695-7	2015	Digitoflavone induced Nrf2 activation and decreased oxidative damage, inflammation, TGF-beta1 expression, extracellular matrix protein expression, and mesangial cell hyperplasia in SV40-Mes13 cells.	Luteolin	0-13	nuclear factor, erythroid derived 2, like 2	Mus musculus	22-26	
26205695-8	2015	Digitoflavone-treated Nrf2+/+ mice, but not Nrf2-/- mice, showed attenuated common metabolic disorder symptoms, improved renal performance, minimized pathological alterations, and decreased oxidative damage, inflammatory gene expression, inflammatory cell infiltration, TGF-beta1 expression, and extracellular matrix protein expression.	Luteolin	0-13	nuclear factor, erythroid derived 2, like 2	Mus musculus	22-26	
26205695-9	2015	Our results show that the anti-oxidative and anti-inflammatory effects of digitoflavone are mediated by Nrf2 activation and that digitoflavone can be used therapeutically to improve metabolic disorders and relieve renal damage induced by diabetes.	Luteolin	74-87	nuclear factor, erythroid derived 2, like 2	Mus musculus	104-108	
24361407-4	2014	Heme oxygenase-1 (HO-1), one of the phase II enzymes showing an antioxidative activity, was potently induced by luteolin and luteolin-7-O-glucoside treatment, which was in accordance with the translocated nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) into nucleus.	Luteolin	112-120	nuclear factor, erythroid derived 2, like 2	Mus musculus	254-258	
24361407-7	2014	Consequently, luteolin and luteolin-7-O-glucoside potently strengthen the HO-1-mediated antioxidative potential through the modulation of the Nrf2/MAPK signaling pathways.	Luteolin	14-22	nuclear factor, erythroid derived 2, like 2	Mus musculus	142-146	
24024667-0	2014	Luteolin, a bioflavonoid inhibits Azoxymethane-induced colorectal cancer through activation of Nrf2 signaling.	Luteolin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	95-99