PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30129150-9 2018 Additionally, quantitative real-time polymerase chain reaction and Western blot analysis were performed to determine the mRNA and protein expression of Nrf2 and its downstream genes after LUT treatment. Luteolin 188-191 NFE2 like bZIP transcription factor 2 Homo sapiens 152-156 30083786-4 2018 Luteolin (3",4",5,7-tetrahydroxyflavone, LUT) is a widespread flavone known to have antioxidant and cytoprotective properties related to nuclear factor erythroid 2-related factor 2-(Nrf2) pathway. Luteolin 0-8 NFE2 like bZIP transcription factor 2 Homo sapiens 137-180 30083786-4 2018 Luteolin (3",4",5,7-tetrahydroxyflavone, LUT) is a widespread flavone known to have antioxidant and cytoprotective properties related to nuclear factor erythroid 2-related factor 2-(Nrf2) pathway. Luteolin 0-8 NFE2 like bZIP transcription factor 2 Homo sapiens 182-186 30083786-4 2018 Luteolin (3",4",5,7-tetrahydroxyflavone, LUT) is a widespread flavone known to have antioxidant and cytoprotective properties related to nuclear factor erythroid 2-related factor 2-(Nrf2) pathway. Luteolin 10-39 NFE2 like bZIP transcription factor 2 Homo sapiens 137-180 30083786-4 2018 Luteolin (3",4",5,7-tetrahydroxyflavone, LUT) is a widespread flavone known to have antioxidant and cytoprotective properties related to nuclear factor erythroid 2-related factor 2-(Nrf2) pathway. Luteolin 10-39 NFE2 like bZIP transcription factor 2 Homo sapiens 182-186 27853236-7 2016 Luteolin enhanced antioxidant defense system based on Keap1, Nrf2, HO-1, NQO1, and KLF9. Luteolin 0-8 NFE2 like bZIP transcription factor 2 Homo sapiens 61-65 24914470-4 2014 In the present study, we investigated the effect of luteolin on the expression of drug-metabolizing enzymes through the AhR and Nrf2 pathways. Luteolin 52-60 NFE2 like bZIP transcription factor 2 Homo sapiens 128-132 24914470-6 2014 Luteolin suppressed TCDD- and tert-butylhydroquinone-induced Nrf2 protein by decreasing its stability in HepG2 cells. Luteolin 0-8 NFE2 like bZIP transcription factor 2 Homo sapiens 61-65 31778952-8 2020 By contrast, high ROS levels, obtained when Nrf2 is inhibited by a small molecule (luteolin), favour apoptosis by upregulating proapoptotic RKIP and downregulating prosurvival Snail. Luteolin 83-91 NFE2 like bZIP transcription factor 2 Homo sapiens 44-48 31778952-11 2020 To test this hypothesis, we used luteolin (3",4",5,7-tetrahydroflavone) as Nrf2 inhibitor, since it reduces the expression of Nrf2 and increases intracellular ROS. Luteolin 33-41 NFE2 like bZIP transcription factor 2 Homo sapiens 75-79 31778952-11 2020 To test this hypothesis, we used luteolin (3",4",5,7-tetrahydroflavone) as Nrf2 inhibitor, since it reduces the expression of Nrf2 and increases intracellular ROS. Luteolin 33-41 NFE2 like bZIP transcription factor 2 Homo sapiens 126-130 30641047-8 2019 Luteolin increased phosphorylation of Nrf2 at Ser40, and MEK inhibitors (U0126 and PD98059) canceled luteolin-induced phosphorylation of Nrf2. Luteolin 0-8 NFE2 like bZIP transcription factor 2 Homo sapiens 38-42 30641047-8 2019 Luteolin increased phosphorylation of Nrf2 at Ser40, and MEK inhibitors (U0126 and PD98059) canceled luteolin-induced phosphorylation of Nrf2. Luteolin 0-8 NFE2 like bZIP transcription factor 2 Homo sapiens 137-141 30641047-10 2019 In conclusion, a physiological concentration of luteolin induces the expression of phase II drug-metabolizing enzymes by enhancement of Nrf2 nuclear accumulation through MEK1/2-ERK1/2-mediated phosphorylation of Nrf2, increasing Nrf2 stability and inducing a conformational change of Keap1. Luteolin 48-56 NFE2 like bZIP transcription factor 2 Homo sapiens 136-140 30641047-10 2019 In conclusion, a physiological concentration of luteolin induces the expression of phase II drug-metabolizing enzymes by enhancement of Nrf2 nuclear accumulation through MEK1/2-ERK1/2-mediated phosphorylation of Nrf2, increasing Nrf2 stability and inducing a conformational change of Keap1. Luteolin 48-56 NFE2 like bZIP transcription factor 2 Homo sapiens 212-216 30641047-10 2019 In conclusion, a physiological concentration of luteolin induces the expression of phase II drug-metabolizing enzymes by enhancement of Nrf2 nuclear accumulation through MEK1/2-ERK1/2-mediated phosphorylation of Nrf2, increasing Nrf2 stability and inducing a conformational change of Keap1. Luteolin 48-56 NFE2 like bZIP transcription factor 2 Homo sapiens 212-216 29277460-13 2018 Luteolin, a potent inhibitor of Nrf2, markedly prevented MRP2 and BCRP expression from being induced by the three Aconitum alkaloids. Luteolin 0-8 NFE2 like bZIP transcription factor 2 Homo sapiens 32-36 24602443-0 2014 Chemoprevention of dietary digitoflavone on colitis-associated colon tumorigenesis through inducing Nrf2 signaling pathway and inhibition of inflammation. Luteolin 27-40 NFE2 like bZIP transcription factor 2 Homo sapiens 100-104 24602443-5 2014 Activation of Nrf2 by digitoflavone was confirmed through mRNA, protein and GSH level assay in Caco-2 cell line. Luteolin 22-35 NFE2 like bZIP transcription factor 2 Homo sapiens 14-18 24602443-6 2014 The cytoprotective effect of digitoflavone was evaluated in H2O2-induced oxidative stress model and further signaling pathways analysis was used to determine the target of digitoflavone induced Nrf2 activation. Luteolin 172-185 NFE2 like bZIP transcription factor 2 Homo sapiens 194-198 24602443-8 2014 RESULT: Micromolarity (10 muM) level of digitoflavone increased Nrf2 expressing, nuclear translocation and expression of downstream phase II antioxidant enzymes. Luteolin 40-53 NFE2 like bZIP transcription factor 2 Homo sapiens 64-68 24602443-9 2014 Furthermore, digitoflavone decreased H2O2-induced oxidative stress and cell death via p38 MAPK-Nrf2/ARE pathway. Luteolin 13-26 NFE2 like bZIP transcription factor 2 Homo sapiens 95-99 24602443-11 2014 CONCLUSION: These observations suggest that digitoflavone is a novel Nrf2 pathway activator, and protects against oxidative stress-induced cell injury. Luteolin 44-57 NFE2 like bZIP transcription factor 2 Homo sapiens 69-73 25040994-3 2014 At physiological concentrations, luteolin as a flavonoid compound can inhibit Nrf2 and sensitize cancer cells to chemotherapeutic agents. Luteolin 33-41 NFE2 like bZIP transcription factor 2 Homo sapiens 78-82 33050575-4 2020 Luteolin, apigenin, quercetin, myricetin, rutin, naringenin, epicatechin, and genistein activate the Nrf2/ARE pathway in both normal and cancer cells. Luteolin 0-8 NFE2 like bZIP transcription factor 2 Homo sapiens 101-105 33050575-8 2020 Paradoxically, some flavonoids, including luteolin, apigenin, and chrysin, inhibit the Nrf2/ARE pathway in vitro. Luteolin 42-50 NFE2 like bZIP transcription factor 2 Homo sapiens 87-91