PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23380370-6	2013	We found that inhibition of the p42/p44 MAPK signaling pathway with a MEK inhibitor (U0126) impairs PR-mediated gene induction, but not gene repression.	U 0126	85-90	cyclin dependent kinase 20	Homo sapiens	32-35	
19088370-3	2008	Treatment with As(2)O(3) resulted in rapid phosphorylation of the p42/p44 MAPK which could be abolished by addition of the MAPK inhibitor, U0126.	U 0126	139-144	cyclin dependent kinase 20	Homo sapiens	66-69	
19559571-10	2009	The HB-EGF-induced eNOS activation was significantly blocked by the p42/p44 MAPK inhibitor U0126 and the phosphatidylinositol 3-kinase (P13K) inhibitor LY294002.	U 0126	91-96	cyclin dependent kinase 20	Homo sapiens	68-71	
18787043-4	2008	We found that short-term inhibition of p42/p44 MAPK activity either by a MAPK kinase inhibitor, U0126, or by depletion of kinase with small interfering RNA caused target gene-specific reductions in AR activity.	U 0126	96-101	cyclin dependent kinase 20	Homo sapiens	39-42	
15573401-7	2005	Pretreatment with U0126 (a MEK1/2 inhibitor) attenuated the p42/p44 MAPK phosphorylation and [3H]thymidine incorporation stimulated by BK, but had no effect on Akt activation.	U 0126	18-23	cyclin dependent kinase 20	Homo sapiens	60-63	
16431916-6	2006	Inhibition of p42/p44 mitogen-activated protein kinase activation by U0126 reduced Bim ubiquitination and Bim degradation and blocked rapid ischemic tolerance.	U 0126	69-74	cyclin dependent kinase 20	Homo sapiens	14-17	
16323212-4	2006	GDNF effects on phosphorylated p42/p44 levels were blocked by the mitogen-activated protein kinase (MAPK) pathway specific inhibitors (PD98059 and U0126).	U 0126	147-152	cyclin dependent kinase 20	Homo sapiens	31-34	
16115207-8	2005	Holotransferrin transcytosis as well as p42-44 MAPK activation are inhibited after addition of a p42-44 MAPK pathway inhibitor (UO126) during TNF-alpha challenge.	U 0126	128-133	cyclin dependent kinase 20	Homo sapiens	40-43	
16115207-8	2005	Holotransferrin transcytosis as well as p42-44 MAPK activation are inhibited after addition of a p42-44 MAPK pathway inhibitor (UO126) during TNF-alpha challenge.	U 0126	128-133	cyclin dependent kinase 20	Homo sapiens	97-100	
15746213-5	2005	Inhibitors of EGFR (AG1478) and p44/p42 MAPK (U0126) phosphorylation blocked redox-dependent p44/p42 phosphorylation, indicating that signaling occurred by EGFR.	U 0126	46-51	cyclin dependent kinase 20	Homo sapiens	36-39	
15982617-10	2005	U0126, a specific inhibitor of p42/p44 ERK, induced a maximal decrease of 84+/-5% (n=8, p<0.001).	U 0126	0-5	cyclin dependent kinase 20	Homo sapiens	31-34	
17591863-11	2007	Preincubation with U0126 abolished carbachol-induced p42/44 MAPK activation and cell proliferation.	U 0126	19-24	cyclin dependent kinase 20	Homo sapiens	53-56	
17303384-5	2007	Consistently, LPS-stimulated phosphorylation of p42/p44 MAPK and p38 was attenuated by pretreatment with U0126 or SB202190, and transfection with these siRNAs, respectively.	U 0126	105-110	cyclin dependent kinase 20	Homo sapiens	48-51	
15772123-6	2005	Immunoblotting studies have shown that leptin fails to activate Akt but increases p42/p44 MAPK phosphorylation, an effect that is prevented by U0126 but not by H-89.	U 0126	143-148	cyclin dependent kinase 20	Homo sapiens	82-85	
14670803-7	2004	Finally, IL-13- or IL-4-dependent eotaxin release was abolished when inhibitors of both p42/p44 ERK (U0126, 10 microM) and p38 (SB202190, 10 microM) mitogen-activated protein kinase pathways were combined in STAT6 antisense ODN-transfected cells.	U 0126	101-106	cyclin dependent kinase 20	Homo sapiens	88-91	
15389584-7	2005	Consistently, IL-1beta stimulated phosphorylation of p42/p44 MAPK and JNK which was attenuated by pretreatment with U0126 or SP600125, respectively.	U 0126	116-121	cyclin dependent kinase 20	Homo sapiens	53-56	
15262180-8	2004	The retinoic acid-stimulated release of VEGF was significantly reduced by PD98059 and U0126, specific MEK inhibitors, which attenuated the retinoic acid-induced phosphorylation of p44/p42 MAP kinase.	U 0126	86-91	cyclin dependent kinase 20	Homo sapiens	184-187	
15194004-4	2004	Inhibition of activated/phosphorylated mitogen-activated protein kinase (MAPK) with phospho-p38 or phospho-p42/44 specific inhibitors, SB203580 or U0126, induces apoptosis without DADS treatment, indicating that at least the endogenous activated forms of p38 MAPK and p42/p44 MAPK markedly exert cytoprotective roles from cell apoptosis in the HepG2 hepatoma cells.	U 0126	147-152	cyclin dependent kinase 20	Homo sapiens	107-110	
15194004-4	2004	Inhibition of activated/phosphorylated mitogen-activated protein kinase (MAPK) with phospho-p38 or phospho-p42/44 specific inhibitors, SB203580 or U0126, induces apoptosis without DADS treatment, indicating that at least the endogenous activated forms of p38 MAPK and p42/p44 MAPK markedly exert cytoprotective roles from cell apoptosis in the HepG2 hepatoma cells.	U 0126	147-152	cyclin dependent kinase 20	Homo sapiens	268-271	
15156564-1	2004	PD98059 and U0126 are considered as specific inhibitors of the p42/44 mitogen-activated protein kinases (MAPK) pathway, which affects osteogenesis and adipogenesis.	U 0126	12-17	cyclin dependent kinase 20	Homo sapiens	63-66	
15156564-4	2004	In contrast, U0126 slightly decreased osteogenesis but had no effects on adipogenesis, although it inhibited p42/44 MAPK more potently than PD98059.	U 0126	13-18	cyclin dependent kinase 20	Homo sapiens	109-112	
15489374-4	2005	Consistently, IL-1beta-stimulated phosphorylation of p42/p44 MAPK, p38, and JNK was attenuated by pretreatment with U0126, SB-202190, or SP-600125, respectively.	U 0126	116-121	cyclin dependent kinase 20	Homo sapiens	53-56	
12853332-7	2003	In addition, both drugs directly induced the phosphorylation of p44 and p42 MAP kinase, which was abolished by the specific inhibitors of MAP kinase activation, PD98059 and U0126.	U 0126	173-178	cyclin dependent kinase 20	Homo sapiens	72-75	
15033174-3	2004	This effect was specifically blocked by inhibitors of phosphatidylinositol 3-kinase (PI3-K) pathways (LY294002 and wortmannin) or p42/p44 mitogen-activated protein (MAP) kinase (PD98059 and U0126).	U 0126	190-195	cyclin dependent kinase 20	Homo sapiens	130-133	
12810818-7	2003	Furthermore, treatment with U0126, an inhibitor of MAPK kinase (MEK)1/2, attenuated the p42/p44 MAPK phosphorylation, but had no effect on Akt activation in response to OxLDL and EGF.	U 0126	28-33	cyclin dependent kinase 20	Homo sapiens	88-91	
12854631-6	2003	U0126, an inhibitor of p42/p44 ERK, also produced a significant decrease in chemokine production (46.3 +/- 9%, P < 0.01 n = 10 and 67.8 +/- 12%, P < 0.01, n = 12).	U 0126	0-5	cyclin dependent kinase 20	Homo sapiens	23-26	
27178245-6	2016	We found that p42/p44 mitogen-activated protein kinase inhibitors, PD98059 and U0126, suppressed the induction of pre-long-term potentiation.	U 0126	79-84	cyclin dependent kinase 20	Homo sapiens	14-17	
11479233-9	2001	Inhibitors of MEK (U0126) and PI3K (LY294002) blocked p42/p44(erk) and Akt, respectively, and partially blocked HGF-induced production of IL-8 and VEGF, whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A.	U 0126	19-24	cyclin dependent kinase 20	Homo sapiens	54-57	
10484455-6	1999	Two different inhibitors of MAPK/extracellular signal-regulated kinase kinase (MEK), PD-98059 and U-0126, inhibited mitogen-induced [3H]thymidine incorporation in a manner consistent with their ability to inhibit p42/p44 activation.	U 0126	98-104	cyclin dependent kinase 20	Homo sapiens	213-216	
11434901-6	2001	Glutamate treatment of differentiated P19 cells triggered a rapid and sustained induction in p42 MAP kinase phosphorylation that was blocked by U0126.	U 0126	144-149	cyclin dependent kinase 20	Homo sapiens	93-96	
11500937-5	2001	We confirmed that PD98059 or U0126 did actually suppress the phosphorylation of p42/p44 MAP kinase by TGF-beta in our preparations.	U 0126	29-34	cyclin dependent kinase 20	Homo sapiens	80-83	
10395291-11	1999	Treatment of HF with U0126 inhibits EGF-induced phosphorylation of p42/44 MAPK as well as crystal- and EGF-induced upregulation of MMP-1 mRNA.	U 0126	21-26	cyclin dependent kinase 20	Homo sapiens	67-70