PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22538822-6	2012	However, the enhanced activity is abrogated by kinase-dead, dominant negative mutants of Raf-1 (Raf-1-K375M) and Mek2 (Mek2-K101A), protein phosphatase PP2A, and Mek-inhibitor U0126, indicative of phosphorylation-dependent regulation.	U 0126	176-181	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	89-94	
23311607-8	2013	Conversely, knockdown of Mirk/Dyrk1B by siRNA led to up-regulated activation of c-Raf-MEK-ERK1/2 pathway and subsequent changes in cell cycle proteins (cyclin D1, p27kip1), accompanied by increased growth rate and cells from G0/G1 into S of cell cycle which could be blocked by U0126 in a dose-dependent manner, indicating Mirk/Dyrk1B may sequester MAPK/ERK pathway, and vice versa.	U 0126	278-283	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	80-85	
22538822-6	2012	However, the enhanced activity is abrogated by kinase-dead, dominant negative mutants of Raf-1 (Raf-1-K375M) and Mek2 (Mek2-K101A), protein phosphatase PP2A, and Mek-inhibitor U0126, indicative of phosphorylation-dependent regulation.	U 0126	176-181	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	96-101	
25961241-5	2011	Increased phosphorylation of p44/42MAPK and c-Raf reflected removal of insulin from the medium and proliferation of all three cell lines was inhibited to a lesser extent by PD98059 and U0126 following long-term oestrogen/insulin withdrawal, demonstrating a reduced dependence on the MAPK pathway.	U 0126	185-190	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	44-49	
22142512-7	2012	Our results showed that CRP markedly activated c-Raf/MEK/ERK and JAK1/ERK signaling pathways but not JAK1/STAT3 signaling pathway by using the phosphor-specific antibodies against these pathways, and blockages of c-Raf/MEK/ERK and JAK1/ERK signaling pathways by the specific ERK1/2 inhibitor U0126 and JAK1 inhibitor piceatannol could significantly decrease CRP-induced MMP-10 expression.	U 0126	292-297	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	47-52	
19881545-6	2010	Reversal of the BAG-1-associated survival phenotype by the mitogen-activated kinase/ERK kinase inhibitor, U0126, implicates the RAF-1-extracellular signal-regulated kinase signaling pathway as a major mediator of BAG-1"s effects in this model.	U 0126	106-111	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	128-133	
17505473-5	2007	Although IFNalpha treatment no longer protected the RAS- or Raf1-overexpressing cells from VSV infection, responsiveness to IFNalpha was restored following treatment with the mitogen-activated protein kinase kinase (MEK) inhibitor U0126.	U 0126	231-236	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	60-64	
19258520-7	2009	Several MEK/ERK pathway intermediates were up-regulated in Hep3B cells; furthermore, transfection of Raf-1 small interfering RNA to suppress MEK/ERK pathway activation sensitized Hep3B cells to U0126.	U 0126	194-199	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	101-106	
19040998-10	2008	Furthermore, treatment of Raf-1-activated cells with U0126, a specific inhibitor of MEK, abrogated these Raf-1-induced effects indicating that the suppression of the metastatic phenotype in MTC cells is a MEK-dependent pathway.	U 0126	53-58	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	26-31	
19040998-10	2008	Furthermore, treatment of Raf-1-activated cells with U0126, a specific inhibitor of MEK, abrogated these Raf-1-induced effects indicating that the suppression of the metastatic phenotype in MTC cells is a MEK-dependent pathway.	U 0126	53-58	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	105-110	
18063082-7	2007	Importantly, blocking of raf-1 pathway by U0126, a potent inhibitor, in the presence of ZM336372 did not reduce the levels of p-GSK-3beta, indicating that GSK-3beta inactivation is independent of raf-1 pathway activation.	U 0126	42-47	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	25-30	
14551213-4	2003	Galpha16QL-induced STAT3 activation was enhanced by overexpression of extracellular signal-regulated kinase 1 (ERK1), but was inhibited by U0126, a Raf-1 inhibitor, and coexpression of the dominant negative mutants of Ras and Rac1.	U 0126	139-144	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	148-153	
17031853-4	2007	The induction of MMP-1 expression correlates with activation of ERK1/2, MEK, and Raf-1, and is potently prevented by U0126, a selective inhibitor of MEK1/2 activation.	U 0126	117-122	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	81-86	
33420899-11	2021	U0126 potentiated JS-K-induced inhibitory effect of Raf/MEK/ERK pathway.	U 0126	0-5	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	52-55	
34282280-8	2021	In addition, the activation of c-Raf and extracellular signal-regulated protein kinases (ERKs) signaling was blocked with PcTX-1 or ASIC1a-shRNA and the proliferation of RASFs was further inhibited by the ERK inhibitor (U0126), indicating that ERK/MAPK signaling contributes to the proliferation process of RASFs promoted by the activation of ASIC1a.	U 0126	220-225	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	31-36	
12851216-7	2003	Furthermore, treatment of BON-raf cells with MEK inhibitors PD-98059 and U-0126 blocked raf-1-mediated morphological changes and hormone suppression but not ERK1/2 phosphorylation.	U 0126	73-79	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	88-93	
12359725-5	2002	Consistent with a role for ERK in Thr-160 phosphorylation, expression of constitutively active Raf-1 induces Thr-160 phosphorylation of CDK2-NLS in serum-arrested cells, an effect that is blocked by treatment with U0126.	U 0126	214-219	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	95-100	
11478855-0	2001	Phosphorylation of raf-1 by kinase suppressor of ras is inhibited by "MEK-specific" inhibitors PD 098059 and U0126 in differentiating HL60 cells.	U 0126	109-114	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	19-24	
29917164-12	2018	Inhibition of c-Raf via U0126 decreased the expression of LGR5 and EpCAM, as well as phosphorylated levels of c-Raf, MEK1/2 and ERK1/2 in the BCPAP cells, compared to levels in the DMSO controls.	U 0126	24-29	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	14-19