PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32558188-10 2020 Stimulation of cultured rat cortical neurons, but not astrocyte, with BDNF, led to marked elevations in the mRNA levels of Vexin, which was inhibited in the presence of K252a and U0126. U 0126 179-184 brain-derived neurotrophic factor Rattus norvegicus 70-74 31195342-6 2019 RESULTS: Our findings revealed that the m-BDNF-inducing activity of HMF was abolished by U0126 but not by H89 or K252a. U 0126 89-94 brain-derived neurotrophic factor Rattus norvegicus 42-46 31306636-7 2019 Mirtazapine treatment increased phosphorylation of extracellular signal-regulated kinase (ERK) 1/2, and the mirtazapine-induced GDNF and BDNF expression were blocked by MAPK/ERK kinase (MEK) inhibitor (U0126). U 0126 202-207 brain-derived neurotrophic factor Rattus norvegicus 137-141 24934279-9 2015 A mitogen-activated protein kinase (MAPK) inhibitor, U0126, suppressed BDNF"s accelerating effect on cell death. U 0126 53-58 brain-derived neurotrophic factor Rattus norvegicus 71-75 28959190-7 2017 Additionally, pharmacological results demonstrated that the application of the ERK1/2 activation inhibitor U0126 into the PPT prevented RSHD and suppressed BDNF expression in the PPT. U 0126 107-112 brain-derived neurotrophic factor Rattus norvegicus 156-160 26295829-8 2016 Furthermore, TSG significantly induced the phosphorylation of extracellular signal-regulated kinase (ERK) 1/2 and a specific ERK inhibitor-U0126 inhibited TSG-mediated secretion of BDNF, GDNF and NGF. U 0126 139-144 brain-derived neurotrophic factor Rattus norvegicus 181-185 26176197-4 2015 Additionally, QUE and rTMS promoted the proliferation and increased the expression of pERK1/2 and BDNF in hippocampal-derived neural stem cells (NSCs), and these effects were abolished by U0126. U 0126 188-193 brain-derived neurotrophic factor Rattus norvegicus 98-102 28732667-7 2017 Importantly, we found that administration of exogenous BDNF into the rACC of intact rats was sufficient to produce CPA, while selectively blocking phosphorylated extracellular signal regulated kinase (p-ERK) with a mitogen-activated protein kinase (MAPK) inhibitor U0126 completely abolished the acquisition of BDNF-induced CPA. U 0126 265-270 brain-derived neurotrophic factor Rattus norvegicus 55-59 27296115-5 2016 Western Blot analysis detected both TrkB receptor isoforms in the synaptosomes but the BDNF effect seems to be mediated by TrkB-FL since: 1) the tyrosine kinase inhibitor, k252a, prevented the effect of BDNF, and 2) the effect of BDNF was lost in the presence of specific inhibitors of TrkB signalling pathways, namely U73122, LY294002 and U0126 (inhibitors of PLC, Akt and MAPK pathways, respectively). U 0126 340-345 brain-derived neurotrophic factor Rattus norvegicus 87-91 27296115-5 2016 Western Blot analysis detected both TrkB receptor isoforms in the synaptosomes but the BDNF effect seems to be mediated by TrkB-FL since: 1) the tyrosine kinase inhibitor, k252a, prevented the effect of BDNF, and 2) the effect of BDNF was lost in the presence of specific inhibitors of TrkB signalling pathways, namely U73122, LY294002 and U0126 (inhibitors of PLC, Akt and MAPK pathways, respectively). U 0126 340-345 brain-derived neurotrophic factor Rattus norvegicus 203-207 27296115-5 2016 Western Blot analysis detected both TrkB receptor isoforms in the synaptosomes but the BDNF effect seems to be mediated by TrkB-FL since: 1) the tyrosine kinase inhibitor, k252a, prevented the effect of BDNF, and 2) the effect of BDNF was lost in the presence of specific inhibitors of TrkB signalling pathways, namely U73122, LY294002 and U0126 (inhibitors of PLC, Akt and MAPK pathways, respectively). U 0126 340-345 brain-derived neurotrophic factor Rattus norvegicus 203-207 26764533-8 2016 The amitriptyline-induced expression of both total and individual BDNF mRNA variants (exon I, IV and VI) were blocked by MEK inhibitor U0126, indicating MEK/ERK signaling is required in the expression of BDNF. U 0126 135-140 brain-derived neurotrophic factor Rattus norvegicus 66-70 26764533-8 2016 The amitriptyline-induced expression of both total and individual BDNF mRNA variants (exon I, IV and VI) were blocked by MEK inhibitor U0126, indicating MEK/ERK signaling is required in the expression of BDNF. U 0126 135-140 brain-derived neurotrophic factor Rattus norvegicus 204-208 21248106-5 2011 The tyrosine kinase inhibitor, K252a, and the mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor, U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene), prevented BDNF"s suppressive effects on cocaine-seeking. U 0126 135-194 brain-derived neurotrophic factor Rattus norvegicus 207-211 22921460-8 2012 Application of exogenous NGF exclusively to the compartment containing DRG nerve terminals in an ex vivo ganglia-nerve preparation markedly increases the BDNF expression level in the DRG neuronal cell body that is placed in a different compartment; this BDNF elevation is attenuated by U0126, PD98059 and a specific ERK5 inhibitor BIX02188. U 0126 286-291 brain-derived neurotrophic factor Rattus norvegicus 254-258 23035088-5 2012 Correspondingly, disruption of the epigenetic regulation of BDNF gene transcription with U0126 or suppression of BDNF signaling with Trk receptor antagonist K252a or BDNF scavenger tyrosine kinase receptor B (TrkB)-Fc blocked extinction of CPA behavior. U 0126 89-94 brain-derived neurotrophic factor Rattus norvegicus 60-64 21248106-7 2011 Additionally, BDNF"s ability to normalize cocaine-mediated decreases in ERK and CREB phosphorylation was blocked by U0126, demonstrating that ERK/MAPK activation mediated the behavioral effects. U 0126 116-121 brain-derived neurotrophic factor Rattus norvegicus 14-18 15579142-6 2004 On the other hand, the nerve growth factor (NGF)-induced increase in BDNF expression in small-to-medium-diameter neurons was reversed by SB203580, whereas the anti-NGF-induced increase in NPY in medium-sized and large-sized neurons was partially blocked by U0126. U 0126 257-262 brain-derived neurotrophic factor Rattus norvegicus 69-73 16942526-8 2006 Neurite measures for BDNF with 25 and 50 microM U0126 (MEK pathway) were reduced to 402.0 and 424.3 microm at 48 hours, respectively (P < 0.05), likely reflecting an accessory molecular pathway. U 0126 48-53 brain-derived neurotrophic factor Rattus norvegicus 21-25 15567516-9 2005 BDNF neuroprotection was also preceded by activation of mitogen activated protein kinase (MAPK) and suppressed by two MAPK/ERK (MEK)-selective inhibitors, PD 98059 and U-0126. U 0126 168-174 brain-derived neurotrophic factor Rattus norvegicus 0-4 17064361-4 2006 Infusion of the extracellular signal-regulated kinase (ERK) inhibitor U0126 blocked BDNF-LTP and modulation of the translation factor activity and expression. U 0126 70-75 brain-derived neurotrophic factor Rattus norvegicus 84-88 12356841-10 2002 Moreover, administration of U0126 and LY294002 decreased significantly, but only partially, the neuroprotective effect of BDNF on the axotomized RGCs. U 0126 28-33 brain-derived neurotrophic factor Rattus norvegicus 122-126 14973246-9 2004 A single intra-VTA infusion of BDNF, but not NGF, induced long-lasting enhancement of cocaine seeking for up to 30 d, an effect reversed by U0126. U 0126 140-145 brain-derived neurotrophic factor Rattus norvegicus 31-35 11389170-5 2001 These changes are accompanied by increased activation of one member of the family of mitogen-activated protein kinases, extracellular signal-regulated kinase (ERK) and the data indicate that these events play a role in modulating release of glutamate from perforant path-granule cell synapses, because the Trk inhibitor K252a and the ERK inhibitor, UO126, both inhibited the BDNF-induced enhancement of release. U 0126 349-354 brain-derived neurotrophic factor Rattus norvegicus 375-379 34977362-7 2021 AT-induced Bdnf mRNA expression was completely blocked by d-(-)-2-Amino-5-phosphonopentanoic acid but partially blocked by nicardipine, U0126, and FK506. U 0126 136-141 brain-derived neurotrophic factor Rattus norvegicus 11-15 10751432-10 2000 Finally, BDNF caused phosphorylation of mitogen-activated protein kinase (MAPK), and because the treatment with the MAPK inhibitor U0126 completely abolished CREB activation and c-fos upregulation, it is likely that both processes depend mainly on the MAP kinase pathway. U 0126 131-136 brain-derived neurotrophic factor Rattus norvegicus 9-13