PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27582689-5	2016	The ethanol-induced suppression was reduced by the D1R antagonist SCH23390 or the PKA inhibitor H89, was prevented by the Akt inhibitor triciribine or the GSk3beta inhibitor SB415286, was enhanced by the NMDA receptor antagonist D-AP5, but was not affected by the MAPK inhibitor U0126 or PI3K inhibitor wortmanin.	U 0126	279-284	AKT serine/threonine kinase 1	Rattus norvegicus	122-125	
35574901-10	2022	The ERK1/2 inhibitor (U0126) and PI3K inhibitor (LY294002) significantly reduced LIPUS-induced phosphorylation of ERK1/2 and PI3K-Akt, respectively, which in turn reduced the LIPUS-induced viability of H9C2s in 3D bio-printed cell-laden GelMA scaffolds.	U 0126	22-27	AKT serine/threonine kinase 1	Rattus norvegicus	130-133	
26424114-6	2015	The inhibition of MEK/ERK1/2 or PI3K/AKT activity by U0126 or wortmannin, but not the inhibition of phospholipase Cgamma by U73122, prevented FGF9-induced gamma-GCS and HO-1 upregulation, changes in cellular redox status, and neuroprotection against MPP(+) toxicity in primary cortical and dopaminergic neurons.	U 0126	53-58	AKT serine/threonine kinase 1	Rattus norvegicus	37-40	
25128810-6	2014	The effects of hispidin on Akt and ERK phosphorylation were abrogated by LY294002 (a PI3K/Akt inhibitor) and U0126 (an ERK1/2 inhibitor).	U 0126	109-114	AKT serine/threonine kinase 1	Rattus norvegicus	27-30	
23200898-7	2013	Western blot analysis also showed that Danshensu increased phosphorylation of Akt and extracellular signal-related kinase 1/2 (ERK1/2) in H9c2 cells, and the protective effects of Danshensu were partially inhibited by phosphatidylinositol 3"-kinase (PI3K) specific inhibitor wortmannin or ERK specific inhibitor U0126.	U 0126	312-317	AKT serine/threonine kinase 1	Rattus norvegicus	78-81	
23266915-6	2013	Furthermore, 17beta-estradiol also prolonged the up-regulation of GSK-3beta pS9 for at least 8 h. However, this action of 17beta-estradiol was abrogated by PKA inhibitor H-89, AKT inhibitor LY294002, and MAPK inhibitor U0126.	U 0126	219-224	AKT serine/threonine kinase 1	Rattus norvegicus	176-179	
24220799-8	2014	Administration of 2-CL-IB-MECA at reperfusion significantly upregulated the status of p-ERK1/2 and p-AKT compared to time matched controls in a UO126 and Wortmannin sensitive manner respectively.	U 0126	144-149	AKT serine/threonine kinase 1	Rattus norvegicus	101-104	
23219579-10	2013	The increasing expressions of p-Akt and p-ERK1/2 induced by Dex in the ischemic hemisphere were markedly inhibited by LY294002 (or wortmannin) and U0126 (or PD98059), respectively.	U 0126	147-152	AKT serine/threonine kinase 1	Rattus norvegicus	32-35	
22609091-6	2012	Inhibition of the PI3K/Akt and ERK1/2 pathways by specific inhibitors, LY294002 and U0126, respectively, partially reduce the protective effect of bFGF.	U 0126	84-89	AKT serine/threonine kinase 1	Rattus norvegicus	23-26	
17902169-5	2008	In accordance with these findings, S1P stimulated phosphorylation of p42/p44 MAPK and Akt which was attenuated by U0126 and wortmannin, respectively.	U 0126	114-119	AKT serine/threonine kinase 1	Rattus norvegicus	86-89	
22064360-8	2012	Addition of pharmacological kinase inhibitors, U0126, SP600125, and LY294002, caused cytotoxicity and the last significantly attenuated NOB- and DTF-mediated antiapoptotic actions, indicating the involvement of PI3K/Akt signaling in their cytoprotective effects.	U 0126	47-52	AKT serine/threonine kinase 1	Rattus norvegicus	216-219	
18927218-8	2009	Inhibition of Akt phosphorylation using Akt inhibitor VIII reversed the inhibitory effect of FSH on thr 172 phosphorylation of AMPK, whereas ERK inhibitor U0126 had no effect.	U 0126	155-160	AKT serine/threonine kinase 1	Rattus norvegicus	14-17	
21964438-4	2011	The PI3K inhibitor LY294002 did not influence the activation of AKT by the Grp75 overexpression under GD; however, the MEK inhibitor U0126 dramatically inhibited AKT phosphorylation in the same assay.	U 0126	133-138	AKT serine/threonine kinase 1	Rattus norvegicus	162-165	
20399244-11	2010	Moreover, U0126 and LY294002, pharmacological inhibitors of MEK1/2 and phosphatidylinositol 3-kinase which are upstream of ERK1/2 and Akt/protein kinase B, respectively attenuated HO-1 and GCLC expression as well as the ARE-driven transcriptional activation of Nrf2.	U 0126	10-15	AKT serine/threonine kinase 1	Rattus norvegicus	134-137	
19830833-8	2010	Blockade of ERK or Akt signaling with U0126 or LY294002 cancelled the OPC-protective effects of astrocyte-conditioned media.	U 0126	38-43	AKT serine/threonine kinase 1	Rattus norvegicus	19-22	
19549072-4	2009	Western blotting experiments showed that H(3)R-mediated activation of Akt in cultured rat cortical neurons was inhibited by LY 294004 and U0126, suggesting that it depends on phosphoinositide-3-kinase and mitogen-activated protein kinase kinase.	U 0126	138-143	AKT serine/threonine kinase 1	Rattus norvegicus	70-73	
15882976-6	2005	LY294002 and U0126, pharmacological inhibitors of phosphatidylinositol 3-kinase and MEK1/2 which are upstream of Akt and ERK1/2, respectively, attenuated resveratrol-induced HO-1 expression and exhibited antioxidant effects.	U 0126	13-18	AKT serine/threonine kinase 1	Rattus norvegicus	113-116	
16508949-6	2006	In accordance with these findings, S1P stimulated phosphorylation of p42/p44 MAPK and Akt, which was attenuated by U0126, LY294002, or wortmannin, respectively.	U 0126	115-120	AKT serine/threonine kinase 1	Rattus norvegicus	86-89	
18182057-7	2008	In addition, N-cadherin expression was partially blocked when signaling from purinergic receptors to extracellular signal regulated protein kinase or Akt was inhibited by 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene or wortmannin, respectively.	U 0126	171-230	AKT serine/threonine kinase 1	Rattus norvegicus	150-153	
17694254-6	2007	LY294002 and UO126, inhibitors of PI3K-Akt and p44/42 phosphorylation respectively, abolished the protective effects of apelin-13 in vitro.Western blot analysis provided further evidence for the involvement of PI3K-Akt and p44/42 in the cardioprotective actions of apelin.	U 0126	13-18	AKT serine/threonine kinase 1	Rattus norvegicus	39-42	
17694254-6	2007	LY294002 and UO126, inhibitors of PI3K-Akt and p44/42 phosphorylation respectively, abolished the protective effects of apelin-13 in vitro.Western blot analysis provided further evidence for the involvement of PI3K-Akt and p44/42 in the cardioprotective actions of apelin.	U 0126	13-18	AKT serine/threonine kinase 1	Rattus norvegicus	215-218	
17591071-8	2007	Treatment with rapamycin resulted in enhanced phosphorylation of AKT, and phosphorylation of AKT was induced by pAxCAHGF plus U0126.	U 0126	126-131	AKT serine/threonine kinase 1	Rattus norvegicus	93-96	
16798728-8	2006	Inhibition of ERK1/2 and Akt activity by U-0126 and LY-294002, respectively, increased TNF-alpha-induced apoptosis.	U 0126	41-47	AKT serine/threonine kinase 1	Rattus norvegicus	25-28	
12951049-9	2003	The activation of AKT, p70(s6k), and ERK1/2 induced by HGF was abolished by pre-treatment with LY294002, a phosphoinositide 3-OH kinase (PI3K) inhibitor, and U0126, a mitogen-activated protein kinase/ERK kinase (MEK) inhibitor, respectively.	U 0126	158-163	AKT serine/threonine kinase 1	Rattus norvegicus	18-21	
15212964-5	2004	When cultured astrocytes were incubated during 8 h simulated ischemia with [1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene] (U0126), an extracellular regulated kinase 1 and 2 (Erk1/2) inhibitor or wortmannin, a phosphatidylinositol 3-kinase (PI3 kinase)/Akt inhibitor, the cell apoptosis was accelerated.	U 0126	138-143	AKT serine/threonine kinase 1	Rattus norvegicus	267-270	
12911620-9	2003	In fact, inhibition of activation of MAPK with U0126 resulted in increased neuritic branching, possibly as a result of the concomitant increase observed in phospho-Akt.	U 0126	47-52	AKT serine/threonine kinase 1	Rattus norvegicus	164-167