PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30073169-9	2018	Activation of the mTORC1/S6K pathway was attenuated by 10-6 M U0126, an MEK/ERK inhibitor, and 10-6 M calphostin C, a PKC inhibitor, indicating that the MEK/ERK/TSC2 axis acts as a mediator.	U 0126	62-67	ribosomal protein S6 kinase B1	Homo sapiens	25-28	
15715661-5	2005	Treatment with different inhibitors including rapamycin, wortmannin, LY294002, and U0126, and their combinations, indicated that phosphorylation of p70S6K and GSK-3beta is regulated by rapamycin-dependent, PI3K and MAPK pathways.	U 0126	83-88	ribosomal protein S6 kinase B1	Homo sapiens	148-154	
28218391-6	2018	Western blot and immunofluorescence analyses showed that U0126 significantly decreased the phosphorylation levels of Tsc2, S6K1, and rpS6 and the expression of KITL, indicating that U0126 inhibits mTORC1-KITL signaling.	U 0126	57-62	ribosomal protein S6 kinase B1	Homo sapiens	123-127	
28218391-6	2018	Western blot and immunofluorescence analyses showed that U0126 significantly decreased the phosphorylation levels of Tsc2, S6K1, and rpS6 and the expression of KITL, indicating that U0126 inhibits mTORC1-KITL signaling.	U 0126	182-187	ribosomal protein S6 kinase B1	Homo sapiens	123-127	
26994515-9	2016	Also, a MEK1/2 inhibitor (U0126) significantly decreased naringenin-induced phosphorylation of ERK1/2, P70S6K and S6K proteins in pTr cells.	U 0126	26-31	ribosomal protein S6 kinase B1	Homo sapiens	103-109	
26994515-9	2016	Also, a MEK1/2 inhibitor (U0126) significantly decreased naringenin-induced phosphorylation of ERK1/2, P70S6K and S6K proteins in pTr cells.	U 0126	26-31	ribosomal protein S6 kinase B1	Homo sapiens	106-109	
25578563-8	2015	Furthermore, the PI3K inhibitors LY294002, BKM120 and MEK inhibitors U0126, PD0325901 blocked the enhanced S6K1 activity induced by Kb.	U 0126	69-74	ribosomal protein S6 kinase B1	Homo sapiens	107-111	
29344155-12	2017	The results showed that the expression of p-ERK and p-P70S6K was downregulated in the cells treated with U0126, while the expression of CD133 remained unaltered.	U 0126	105-110	ribosomal protein S6 kinase B1	Homo sapiens	54-60	
26432159-9	2015	However, both kinase inhibitor U0126 and the DNA (cytosine-5-)-methyltransferase 1 (DNMT1) inhibitor 5-aza-deoxycytidine abolished the effect of arsenite on expressions of PTEN and p-p70S6K.	U 0126	31-36	ribosomal protein S6 kinase B1	Homo sapiens	183-189	
24073294-13	2013	Inhibition of ERK1/2 by U0126 also abolished activity of p70S6K both in vitro and in vivo models.	U 0126	24-29	ribosomal protein S6 kinase B1	Homo sapiens	57-63	
16139919-4	2005	RESULTS: The phophatidylinositol 3-kinase (PI3K) inhibitor LY294002 and the mitogen-activated protein kinase inhibitor, UO126, decreased the TGF-beta1-dependent ADAM12 expression and prevented the phosphorylation of p70S6K.	U 0126	120-125	ribosomal protein S6 kinase B1	Homo sapiens	216-222	
12395317-7	2002	No interference between the MEK/ERK pathway and 4E-BP1 phosphorylation was detected, whereas p70S6K phosphorylation induced by EGF was under a U0126-sensitive regulation.	U 0126	143-148	ribosomal protein S6 kinase B1	Homo sapiens	93-99	
12489846-2	2002	We reported that the mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) inhibitor U0126 inhibited anchorage-independent growth of Ki-ras-transformed rat fibroblasts by simultaneously blocking both extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin (mTOR)-p70(S6K) pathways.	U 0126	108-113	ribosomal protein S6 kinase B1	Homo sapiens	308-315	
12489846-13	2002	U0126 was either without effect or less inhibitory on p70(S6K) in MDA-MB453 and SKBR3, two cell lines in which anoikis sensitivity was not induced.	U 0126	0-5	ribosomal protein S6 kinase B1	Homo sapiens	54-57	
12704019-2	2003	Here we report that isoproterenol phosphorylated the protein S6 kinase (p70S6k) in alveolar epithelial cells, which was inhibited by both rapamycin and the MEK1/2 inhibitor U-0126.	U 0126	173-179	ribosomal protein S6 kinase B1	Homo sapiens	72-78	
11940578-6	2002	Dominant negative c-Raf expression or a MEK1/2 inhibitor (U0126) treatment showed a profound blocking effect only on the TPA-stimulated phosphorylation of S6K1 and mTOR.	U 0126	58-63	ribosomal protein S6 kinase B1	Homo sapiens	155-159	
11108720-8	2001	Pretreatment of cells with the mitogen-activated protein-extracellular signal-regulated kinase kinase (MEK) inhibitor U0126 inhibited S6K2 activation to a greater extent than S6K1.	U 0126	118-123	ribosomal protein S6 kinase B1	Homo sapiens	175-179