PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26696494-7 2016 In addition, inhibition of extracellular protein kinase (ERK) with U0126 shared with the AST the same beneficial effects in reducing Abeta-induced apoptosis. U 0126 67-72 amyloid beta precursor protein Rattus norvegicus 133-138 22913737-3 2013 We found that caspase-3 and Bax/Bcl-2 ratio, two hallmarks of apoptosis, were significantly decreased in the rats pre-treated with U0126 and PD169316, 7 days after Abeta injection. U 0126 131-136 amyloid beta precursor protein Rattus norvegicus 164-169 22913737-4 2013 This observation was in agreement with the results of immunostaining analysis of the hippocampus that showed decreased levels of terminal transferase dUTP nick end labelling positive cells in the hippocampus of U0126 and PD169316 pre-treated rats, compared with the Abeta-injected group. U 0126 211-216 amyloid beta precursor protein Rattus norvegicus 266-271 22510382-1 2012 In this study, we investigated the effect of intracerebroventricular administration of ERK and p38 specific inhibitors, U0126 and PD169316, respectively, on learning and memory deficits induced by amyloid beta (Abeta) in rats. U 0126 120-125 amyloid beta precursor protein Rattus norvegicus 211-216 22510382-3 2012 U0126 and/or PD169316 improved spatial learning in MWM in Abeta-injected rats, 20 days after Abeta-injection. U 0126 0-5 amyloid beta precursor protein Rattus norvegicus 58-63 22510382-3 2012 U0126 and/or PD169316 improved spatial learning in MWM in Abeta-injected rats, 20 days after Abeta-injection. U 0126 0-5 amyloid beta precursor protein Rattus norvegicus 93-98 22510382-6 2012 Moreover, U0126 and PD169316 activated peroxisome proliferator-activated receptor gamma coactivator-1a, nuclear respiratory factor 1, and mitochondrial transcription factor A, 7 days after Abeta-injection. U 0126 10-15 amyloid beta precursor protein Rattus norvegicus 189-194 14646244-3 2003 The A beta-induced increase in tyrosine phosphorylation of 44-kDa protein was blocked by U0126, a specific inhibitor of the extracellular signal-regulated kinase (ERK) kinase MEK. U 0126 89-94 amyloid beta precursor protein Rattus norvegicus 4-10 22913737-8 2013 U0126 and PD169316 activated Nrf2 and suppressed NF-kB pathways, 7 days after Abeta injection. U 0126 0-5 amyloid beta precursor protein Rattus norvegicus 78-83