PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25662951-8	2015	Treatment with U0126, a MAPK pathway inhibitor, reduces Pol IIser5p association with the JUNB proximal promoter and reduces JUNB expression.	U 0126	15-20	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	89-93	
28012925-7	2017	Interestingly, treatment with ERK1/2 inhibitor U0126 effectively abrogated CSE-triggered EMT and ERK1/2/AP-1 activation.	U 0126	47-52	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	104-108	
26320741-5	2016	LPS and Pam3csk4 also induced IRAK1/4-, ERK- and ROS-dependent activation of activator protein-1 (AP-1), IL-1beta transcription, and IL-1beta processing because significant inhibition in AP-1 activity, IL-1beta transcription, Pro- and mature IL-beta expression, and caspase-1 activity was observed with PD98059, U0126, DPI, NAC, an IRAK1/4 inhibitor, tanshinone IIa, and IRAK1 siRNA treatment.	U 0126	312-317	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	77-96	
26320741-5	2016	LPS and Pam3csk4 also induced IRAK1/4-, ERK- and ROS-dependent activation of activator protein-1 (AP-1), IL-1beta transcription, and IL-1beta processing because significant inhibition in AP-1 activity, IL-1beta transcription, Pro- and mature IL-beta expression, and caspase-1 activity was observed with PD98059, U0126, DPI, NAC, an IRAK1/4 inhibitor, tanshinone IIa, and IRAK1 siRNA treatment.	U 0126	312-317	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	98-102	
25662951-8	2015	Treatment with U0126, a MAPK pathway inhibitor, reduces Pol IIser5p association with the JUNB proximal promoter and reduces JUNB expression.	U 0126	15-20	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	124-128	
25662951-10	2015	U0126 treatment reduces OSM-induced Pol IIser5p binding to the JUNB proximal promoter and JUNB expression, but does not reduce pSTAT3 levels or the association of pSTAT3 with the JUNB proximal promoter.	U 0126	0-5	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	63-67	
25662951-10	2015	U0126 treatment reduces OSM-induced Pol IIser5p binding to the JUNB proximal promoter and JUNB expression, but does not reduce pSTAT3 levels or the association of pSTAT3 with the JUNB proximal promoter.	U 0126	0-5	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	90-94	
25662951-10	2015	U0126 treatment reduces OSM-induced Pol IIser5p binding to the JUNB proximal promoter and JUNB expression, but does not reduce pSTAT3 levels or the association of pSTAT3 with the JUNB proximal promoter.	U 0126	0-5	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	90-94	
20432452-6	2010	IL-1beta-stimulated AP-1 activation was blocked by U0126 or SP600125, revealing that ERK and JNK linked to AP-1 on these responses.	U 0126	51-56	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	20-24	
22659134-4	2012	High glucose-induced AP-1 DNA binding activity was decreased by Syk inhibitors and U0126 (an ERK inhibitor).	U 0126	83-88	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	21-25	
20448669-4	2010	Interestingly, a combination of ALK gene silencing with U0126, a kinase inhibitor specific for the extracellular signal-regulated kinases 1/2 pathway, resulted in an augmented reduction in cellular JunB expression.	U 0126	56-61	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	198-202	
20432452-6	2010	IL-1beta-stimulated AP-1 activation was blocked by U0126 or SP600125, revealing that ERK and JNK linked to AP-1 on these responses.	U 0126	51-56	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	107-111	
15474068-11	2004	Electrophoretic mobility shift assay revealed that U0126 attenuated activator protein-1 (AP-1) activation induced by TNF-alpha.	U 0126	51-56	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	68-87	
15843518-7	2005	In contrast, H4R stimulation did not affect cAMP production but induced the transcription factor AP-1, and U0126, an inhibitor of AP-1 transactivation and MEK, rescued H4R mediated IL-12p70 suppression.	U 0126	107-112	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	130-134	
18474417-6	2008	Pharmacological inhibition of MEK1/2-ERK1/2 pathway with UO126 blocked caspase-3 activation, decreased AP-1 binding to DNA and inhibited apoptosis.	U 0126	57-62	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	103-107	
15993752-10	2005	Using gel shift analysis, we found that forskolin activation of T-cells resulted in activation of AP1 sites; this increase in nuclear extract AP1 was significantly blocked by MEK1 inhibitor U0126.	U 0126	190-195	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	98-101	
15993752-10	2005	Using gel shift analysis, we found that forskolin activation of T-cells resulted in activation of AP1 sites; this increase in nuclear extract AP1 was significantly blocked by MEK1 inhibitor U0126.	U 0126	190-195	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	142-145	
15474068-11	2004	Electrophoretic mobility shift assay revealed that U0126 attenuated activator protein-1 (AP-1) activation induced by TNF-alpha.	U 0126	51-56	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	89-93	
15086566-7	2004	Twenty-four hours of stretching stimulated reporter activity driven by activator protein 1 (AP-1), induction of K6, and suppression of K10, which were inhibited by U0126.	U 0126	164-169	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	71-90	
15086566-7	2004	Twenty-four hours of stretching stimulated reporter activity driven by activator protein 1 (AP-1), induction of K6, and suppression of K10, which were inhibited by U0126.	U 0126	164-169	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	92-96