PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30964170-11	2019	ATG5 could directly bind to miRNA-153-3p, and ATG5 was highly expressed in gefitinib-resistant NSCLC.	Gefitinib	75-84	autophagy related 5	Homo sapiens	0-4	
30964170-0	2019	MiRNA-153-3p promotes gefitinib-sensitivity in non-small cell lung cancer by inhibiting ATG5 expression and autophagy.	Gefitinib	22-31	autophagy related 5	Homo sapiens	88-92	
30964170-2	2019	PATIENTS AND METHODS: The expressions of miRNA-153-3p, LC3B and ATG5 in gefitinib-resistant and gefitinib-sensitive NSCLC tissues were determined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR).	Gefitinib	72-81	autophagy related 5	Homo sapiens	64-68	
30964170-6	2019	The regulatory effects of miRNA-153-3p/ATG5 on gefitinib-sensitivity and apoptosis were finally examined by cytotoxicity assay and Annexin V-fluorescein isothiocyanate (FITC)/Propidium Iodide (PI) staining, respectively.	Gefitinib	47-56	autophagy related 5	Homo sapiens	39-43	
30964170-11	2019	ATG5 could directly bind to miRNA-153-3p, and ATG5 was highly expressed in gefitinib-resistant NSCLC.	Gefitinib	75-84	autophagy related 5	Homo sapiens	46-50	
30964170-12	2019	The correlation analysis found a negative correlation between ATG5 and miRNA-153-3p and a positive correlation between ATG5 and LC3B in gefitinib-resistant NSCLC.	Gefitinib	136-145	autophagy related 5	Homo sapiens	119-123	
30964170-13	2019	More importantly, ATG5 reversed the regulatory effects of miRNA-153-3p on autophagy, gefitinib-sensitivity and apoptosis of PC-9/GR and HCC827/GR cells.	Gefitinib	85-94	autophagy related 5	Homo sapiens	18-22	
30964170-15	2019	The overexpression of miRNA-153-3p enhances gefitinib-sensitivity in NSCLC by inhibiting autophagy via downregulating ATG5.	Gefitinib	44-53	autophagy related 5	Homo sapiens	118-122	
29259263-6	2017	We also found that ATG5 rs510432, ATG5 rs688810, ATG10 rs10036653 and ATG10 rs1864182 were associated with primary or acquired resistance to gefitinib.	Gefitinib	141-150	autophagy related 5	Homo sapiens	19-23	
29717538-5	2018	Western blotting indicated that gefitinib combined with CUR, DMC, or BDMC led to decrease Bcl-2 protein expression which is an antiapoptotic protein and to increase ATG5, Beclin 1, p62/SQSTM1, and LC3 expression that associated with cell autophagy in SAS cells.	Gefitinib	32-41	autophagy related 5	Homo sapiens	165-169	
29259263-6	2017	We also found that ATG5 rs510432, ATG5 rs688810, ATG10 rs10036653 and ATG10 rs1864182 were associated with primary or acquired resistance to gefitinib.	Gefitinib	141-150	autophagy related 5	Homo sapiens	34-38	
28399862-5	2017	METHODS: We designed chitosan nanoparticles (NPs) to promote the co-delivery of gefitinib (an anti-cancer drug) and shRNA-expressing plasmid DNA that targets the Atg-5 gene (shAtg-5) as an autophagy inhibitor to improve anti-cancer effects and autophagy mediation.	Gefitinib	80-89	autophagy related 5	Homo sapiens	162-167	
24965408-13	2014	Compound C AMPK inhibitor could reverse the activation of gefitinib on autophagy, as determined by Beclin 1, Atg5 and Atg7 mRNA levels.	Gefitinib	58-67	autophagy related 5	Homo sapiens	109-113	
21655094-6	2011	Moreover, cytotoxicity induced by gefitinib or erlotinib was greatly enhanced after autophagy inhibition by the pharmacological inhibitor chloroquine (CQ) and siRNAs targeting ATG5 and ATG7, the most important components for the formation of autophagosome.	Gefitinib	34-43	autophagy related 5	Homo sapiens	176-180