PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21709443-8 2011 METHODS: The cytotoxicity of topotecan after conventional or metronomic dosing was determined by examining cellular morphology, mitochondrial enzymatic activity (MTT), total cellular protein (SRB), annexin V and propidium iodine (PI) staining, cell cycle and western blot analysis in human prostate cancer cell lines (PC-3 and LNCaP) and the effects metronomic or continuous infusion on tumor growth in an in vivo tumor xenograft model. Topotecan 29-38 chaperonin containing TCP1 subunit 4 Homo sapiens 192-195