PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20460504-0	2010	Tyrosine kinase inhibitor gefitinib enhances topotecan penetration of gliomas.	Topotecan	45-54	TXK tyrosine kinase	Homo sapiens	0-15	
20460504-1	2010	Gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, increases brain parenchymal extracellular fluid (ECF) accumulation of topotecan, a substrate of the ATP-binding cassette (ABC) transporters P-glycoprotein (Pgp/MDR-1) and breast cancer resistance protein (BCRP/ABCG2).	Topotecan	144-153	TXK tyrosine kinase	Homo sapiens	47-62