PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20145144-0 2010 Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan. Topotecan 113-122 breast cancer 1, early onset Mus musculus 39-44 23028879-2 2012 Using our conditional K14cre;Brca1(F/F);p53(F/F) mouse model, we showed previously that BRCA1;p53-deficient mammary tumors initially respond to topotecan, but frequently acquire resistance by overexpression of the efflux transporter ABCG2. Topotecan 144-153 breast cancer 1, early onset Mus musculus 88-93