PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32999163-2	2020	Emodin, the predominant compound of traditional medicine rhubarb, was reported to inhibit the multidrug resistance by downregulating P-glycoprotein of K562/ADM cells with overexpression of P-glycoprotein in our previous studies.	Emodin	0-6	ATP binding cassette subfamily B member 1	Homo sapiens	133-147	
32934734-0	2020	Emodin alleviates gemcitabine resistance in pancreatic cancer by inhibiting MDR1/P-glycoprotein and MRPs expression.	Emodin	0-6	ATP binding cassette subfamily B member 1	Homo sapiens	81-95	
32934734-12	2020	In addition, emodin treatment reduced resistance to gemcitabine, which was characterized by the downregulation of P-glycoprotein, MRP1 and MRP5 expression in the group receiving combination treatment.	Emodin	13-19	ATP binding cassette subfamily B member 1	Homo sapiens	114-128	
32934734-13	2020	The level of P-glycoprotein was also decreased in the group treated with gemcitabine+emodin compared with the single treatment groups.	Emodin	85-91	ATP binding cassette subfamily B member 1	Homo sapiens	13-27	
32934734-14	2020	Taken together, these results demonstrated that emodin enhanced gemcitabine efficacy in tumor treatment and alleviated gemcitabine resistance in PANC-1 cell xenografts in mice via suppressing MDR1/P-glycoprotein and MRP expression.	Emodin	48-54	ATP binding cassette subfamily B member 1	Homo sapiens	197-211	
34001704-11	2021	Further investigation indicated that reinforcement effect of emodin and DDP may be associated with inhibition of NF-kappaB pathway and drug efflux-related proteins such as P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP) and Glutathione S-transferase (GST).	Emodin	61-67	ATP binding cassette subfamily B member 1	Homo sapiens	172-186	
34001704-11	2021	Further investigation indicated that reinforcement effect of emodin and DDP may be associated with inhibition of NF-kappaB pathway and drug efflux-related proteins such as P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP) and Glutathione S-transferase (GST).	Emodin	61-67	ATP binding cassette subfamily B member 1	Homo sapiens	188-192	
34001704-14	2021	CONCLUSIONS: Emodin reverses the cisplatin resistance of tumor cells by down-regulating expression of P-gp, MRP and GST, increasing the intracellular accumulation in A549/DDP cells, and the effect may be associated with the NF-kappaB pathways.	Emodin	13-19	ATP binding cassette subfamily B member 1	Homo sapiens	102-106	
32999163-2	2020	Emodin, the predominant compound of traditional medicine rhubarb, was reported to inhibit the multidrug resistance by downregulating P-glycoprotein of K562/ADM cells with overexpression of P-glycoprotein in our previous studies.	Emodin	0-6	ATP binding cassette subfamily B member 1	Homo sapiens	189-203	
29121121-5	2017	Moreover, when incubated with emodin under different conditions where P-gp was inhibited, K562/ADM cells displayed increasing intracellular uptake of emodin, suggesting that emodin may be the potential substrate of P-gp.	Emodin	30-36	ATP binding cassette subfamily B member 1	Homo sapiens	70-74	
29121121-5	2017	Moreover, when incubated with emodin under different conditions where P-gp was inhibited, K562/ADM cells displayed increasing intracellular uptake of emodin, suggesting that emodin may be the potential substrate of P-gp.	Emodin	30-36	ATP binding cassette subfamily B member 1	Homo sapiens	215-219	
29121121-5	2017	Moreover, when incubated with emodin under different conditions where P-gp was inhibited, K562/ADM cells displayed increasing intracellular uptake of emodin, suggesting that emodin may be the potential substrate of P-gp.	Emodin	150-156	ATP binding cassette subfamily B member 1	Homo sapiens	70-74	
29121121-5	2017	Moreover, when incubated with emodin under different conditions where P-gp was inhibited, K562/ADM cells displayed increasing intracellular uptake of emodin, suggesting that emodin may be the potential substrate of P-gp.	Emodin	150-156	ATP binding cassette subfamily B member 1	Homo sapiens	215-219