PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22565822-6	2013	Furthermore, emodin increased the protein level of p53 and decreased the protein level of NF-kappaB/p65 in HepG2 cells, which indicated these two regulators might play a role in emodin-induced apoptosis.	Emodin	13-19	tumor protein p53	Homo sapiens	51-54	
29355754-7	2018	We went on to study the effect of blocking protein aggregation by emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) and figured that inhibiting p53 protein aggregation can elevate the level of autophagy in A549 lung cancer cell line while there is no significant effect on autophagy in normal non-cancerous HaCaT cells.	Emodin	74-113	tumor protein p53	Homo sapiens	143-146	
14987952-7	2004	Taken together, emodin displays effective inhibitory effects on the growth of various human hepatoma cell lines and stimulates the expression of p53 and p21 that resulted in the cell cycle arrest of HepG2/C3A cells at G(2)/M phase.	Emodin	16-22	tumor protein p53	Homo sapiens	145-148	
30370860-12	2019	We also observed that both compounds up-regulated the p53 expression where Emodin causes nuclear p53 localization, which leads to down-regulation in mTOR expression and induces autophagy while Chrysophanol inhibits p53 translocation into nucleus, up-regulates mTOR expression and inhibits autophagy.	Emodin	75-81	tumor protein p53	Homo sapiens	54-57	
30370860-12	2019	We also observed that both compounds up-regulated the p53 expression where Emodin causes nuclear p53 localization, which leads to down-regulation in mTOR expression and induces autophagy while Chrysophanol inhibits p53 translocation into nucleus, up-regulates mTOR expression and inhibits autophagy.	Emodin	75-81	tumor protein p53	Homo sapiens	97-100	
30370860-12	2019	We also observed that both compounds up-regulated the p53 expression where Emodin causes nuclear p53 localization, which leads to down-regulation in mTOR expression and induces autophagy while Chrysophanol inhibits p53 translocation into nucleus, up-regulates mTOR expression and inhibits autophagy.	Emodin	75-81	tumor protein p53	Homo sapiens	97-100