PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31114158-9	2019	In addition, we found that emodin significantly enhanced PTX-induced apoptosis in A549 cells via increasing the expressions of Bax and active caspase 3 and decreasing the levels of Bcl-2, p-Akt and p-ERK.	Emodin	27-33	mitogen-activated protein kinase 1	Homo sapiens	200-203	
34041746-8	2021	Emodin also inhibits activation of several canonical (SMAD2/3) and noncanonical (Erk1/2) TGF-beta signaling pathways, while activating the p38 pathway.	Emodin	0-6	mitogen-activated protein kinase 1	Homo sapiens	139-142	
34615812-4	2021	Resultantly, the the Polygonum cuspidatum ethyl acetate subfraction containing emodin (F3a) promoted Raji cell death (50% cytotoxic concentration, CC50: 12.08 mug/mL); the 12.5 mug/mL F3a effect transcribed BRLF1 and BNLF1 and increased latent membrane protein 1 (LMP1), which may reduce the intracellular phospho-ERK and phospho-IkappaBalpha.	Emodin	79-85	mitogen-activated protein kinase 1	Homo sapiens	314-317	
35197857-3	2022	We hypothesized that natural anthraquinone derivative emodin can protect against neurotoxicity induced by pathological concentrations of zinc via the extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway and alleviate oxidative stress and mitochondrial dysfunction.	Emodin	54-60	mitogen-activated protein kinase 1	Homo sapiens	150-191