PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33621883-0 2021 Molecular mechanism study of BPAF-induced proliferation of ERalpha-negative SKBR-3 human breast cancer cells in vitro/in vivo. 4,4'-hexafluorisopropylidene diphenol 29-33 estrogen receptor 1 Homo sapiens 59-66 33857583-1 2021 As demonstrated for bisphenol AF (BPAF), the electrostatic halogen bond based on the London dispersion force of halogen atoms was found to be a major driving force of their bifunctional ERalpha-agonist and ERbeta-antagonist activities. 4,4'-hexafluorisopropylidene diphenol 34-38 estrogen receptor 1 Homo sapiens 186-193 33857583-1 2021 As demonstrated for bisphenol AF (BPAF), the electrostatic halogen bond based on the London dispersion force of halogen atoms was found to be a major driving force of their bifunctional ERalpha-agonist and ERbeta-antagonist activities. 4,4'-hexafluorisopropylidene diphenol 34-38 estrogen receptor 1 Homo sapiens 206-212 33621883-1 2021 Bisphenol AF (BPAF) is a known estrogen disruptor of the ERalpha pathway. 4,4'-hexafluorisopropylidene diphenol 14-18 estrogen receptor 1 Homo sapiens 57-64 33621883-2 2021 The aim of the present study was to characterize the proliferation effects of BPAF on ERalpha-negative SKBR-3 breast cancer cells with mechanistic insights. 4,4'-hexafluorisopropylidene diphenol 78-82 estrogen receptor 1 Homo sapiens 86-93 33621883-10 2021 These results provide mechanistic insights into the effects of BPAF regarding ERalpha-negative human breast cancer development. 4,4'-hexafluorisopropylidene diphenol 63-67 estrogen receptor 1 Homo sapiens 78-85 33561155-1 2021 We reported that bisphenol AF (BPAF) works as an agonist for estrogen receptor (ER) ERalpha but as an antagonist for ERbeta. 4,4'-hexafluorisopropylidene diphenol 31-35 estrogen receptor 1 Homo sapiens 61-78 33561155-1 2021 We reported that bisphenol AF (BPAF) works as an agonist for estrogen receptor (ER) ERalpha but as an antagonist for ERbeta. 4,4'-hexafluorisopropylidene diphenol 31-35 estrogen receptor 1 Homo sapiens 80-82 33561155-1 2021 We reported that bisphenol AF (BPAF) works as an agonist for estrogen receptor (ER) ERalpha but as an antagonist for ERbeta. 4,4'-hexafluorisopropylidene diphenol 31-35 estrogen receptor 1 Homo sapiens 84-91 33561155-1 2021 We reported that bisphenol AF (BPAF) works as an agonist for estrogen receptor (ER) ERalpha but as an antagonist for ERbeta. 4,4'-hexafluorisopropylidene diphenol 31-35 estrogen receptor 1 Homo sapiens 117-123 31879182-2 2020 We recently observed that CF3-containing bisphenol AF (BPAF) works as an agonist for ERalpha but as an antagonist for ERbeta. 4,4'-hexafluorisopropylidene diphenol 55-59 estrogen receptor 1 Homo sapiens 85-92 33189448-8 2021 Furthermore, the role of Ca2+ overload and estrogen receptor beta (ERbeta) in BPAF-induced KGN cell apoptosis was also confirmed by using inhibitors. 4,4'-hexafluorisopropylidene diphenol 78-82 estrogen receptor 1 Homo sapiens 43-65 33189448-8 2021 Furthermore, the role of Ca2+ overload and estrogen receptor beta (ERbeta) in BPAF-induced KGN cell apoptosis was also confirmed by using inhibitors. 4,4'-hexafluorisopropylidene diphenol 78-82 estrogen receptor 1 Homo sapiens 67-73 33189448-10 2021 In addition, Ca2+ overload and ERbeta pathway activation may also be an important mechanism of reproductive toxicity of BPAF. 4,4'-hexafluorisopropylidene diphenol 120-124 estrogen receptor 1 Homo sapiens 31-37 31879182-2 2020 We recently observed that CF3-containing bisphenol AF (BPAF) works as an agonist for ERalpha but as an antagonist for ERbeta. 4,4'-hexafluorisopropylidene diphenol 55-59 estrogen receptor 1 Homo sapiens 118-124 31879182-9 2020 The ascending order of agonist/antagonist dual biological functions was BPE-F < BPE-Cl (HPTE) <= BPAF < BPE-Br, demonstrating that the electrostatic halogen bonding effect is a major driving force of the bifunctional ERalpha agonist and ERbeta antagonist activities of BPAF. 4,4'-hexafluorisopropylidene diphenol 269-273 estrogen receptor 1 Homo sapiens 217-224 30590302-5 2019 BPAF in low concentration significantly enhances the protein expression of estrogen receptor alpha (ERalpha), G protein-coupled receptor (GPER), c-Myc, and Cyclin D1, as well as increases phosphorylation levels of protein kinase B (Akt) and extracellular signal-regulated kinase (Erk) in MCF-7 cells. 4,4'-hexafluorisopropylidene diphenol 0-4 estrogen receptor 1 Homo sapiens 75-98 31059536-6 2019 We found that BPAF promoted cell growth and cell cycle progression concurrently with BPAF-induced ERalpha transcriptional activity and ER-RTK signaling activation. 4,4'-hexafluorisopropylidene diphenol 14-18 estrogen receptor 1 Homo sapiens 98-105 31059536-6 2019 We found that BPAF promoted cell growth and cell cycle progression concurrently with BPAF-induced ERalpha transcriptional activity and ER-RTK signaling activation. 4,4'-hexafluorisopropylidene diphenol 85-89 estrogen receptor 1 Homo sapiens 98-105 30590302-5 2019 BPAF in low concentration significantly enhances the protein expression of estrogen receptor alpha (ERalpha), G protein-coupled receptor (GPER), c-Myc, and Cyclin D1, as well as increases phosphorylation levels of protein kinase B (Akt) and extracellular signal-regulated kinase (Erk) in MCF-7 cells. 4,4'-hexafluorisopropylidene diphenol 0-4 estrogen receptor 1 Homo sapiens 100-107 24349450-1 2013 Bisphenol AF (BPAF), an endocrine disrupting chemical, can induce estrogenic activity through binding to estrogen receptor (ER). 4,4'-hexafluorisopropylidene diphenol 14-18 estrogen receptor 1 Homo sapiens 105-122 29743443-3 2018 BPAF has been established as an activator of estrogen receptor alpha (ERalpha) in many cell lines; however, controversy surrounds its effects on the other isoform, ERbeta (i.e., whether it functions as a stimulator). 4,4'-hexafluorisopropylidene diphenol 0-4 estrogen receptor 1 Homo sapiens 45-68 29743443-3 2018 BPAF has been established as an activator of estrogen receptor alpha (ERalpha) in many cell lines; however, controversy surrounds its effects on the other isoform, ERbeta (i.e., whether it functions as a stimulator). 4,4'-hexafluorisopropylidene diphenol 0-4 estrogen receptor 1 Homo sapiens 70-77 29093337-6 2017 Among these bisphenols, BPAF up-regulated the expression of ERbeta, and this was coupled with the abrogation of estrogen response element (ERE)-mediated transcriptional activities as well as the down-regulation of Cdc2 expression in MCF-7 cells, without influencing the expression of ERalpha. 4,4'-hexafluorisopropylidene diphenol 24-28 estrogen receptor 1 Homo sapiens 284-291 29093337-7 2017 BPAF functioned as an agonist of ERalpha at lower concentrations (nanomolar order), but did not exhibit any modulatory action on ERalpha transiently expressed in SK-BR-3 cells in the presence or absence of 17beta-estradiol (E2) at higher concentrations (micromolar order). 4,4'-hexafluorisopropylidene diphenol 0-4 estrogen receptor 1 Homo sapiens 33-40 29093337-9 2017 Since ERbeta is a suppressive molecule of ERalpha function, these results provide rational evidence for BPAF functioning as an anti-estrogenic compound via the induction of ERbeta at higher concentrations. 4,4'-hexafluorisopropylidene diphenol 104-108 estrogen receptor 1 Homo sapiens 42-49 24727858-9 2014 Taken together, these results indicate that BPAF-induced endogenous transcription of estrogen responsive genes is mediated through both genomic and nongenomic pathways involving the ERalpha and ERK1/2 activation in human breast cancer cells. 4,4'-hexafluorisopropylidene diphenol 44-48 estrogen receptor 1 Homo sapiens 182-189 29389661-7 2018 RESULTS: We demonstrated that BPA and BPAF have agonistic activity for both ERalpha and ERbeta, but BPS has ERalpha-selective specificity. 4,4'-hexafluorisopropylidene diphenol 38-42 estrogen receptor 1 Homo sapiens 76-83 29389661-11 2018 In addition, the binding surface of coregulator interactions on ERalpha was characterized for the BPA, BPAF, and BPS complexes. 4,4'-hexafluorisopropylidene diphenol 103-107 estrogen receptor 1 Homo sapiens 64-71 24349450-1 2013 Bisphenol AF (BPAF), an endocrine disrupting chemical, can induce estrogenic activity through binding to estrogen receptor (ER). 4,4'-hexafluorisopropylidene diphenol 14-18 estrogen receptor 1 Homo sapiens 124-126 24349450-8 2013 To explain the biological function of BPAF biotransformation, the estrogenic activities of BPAF and BPAF-G were evaluated in ER-positive breast cancer T47D and MCF7 cells. 4,4'-hexafluorisopropylidene diphenol 91-95 estrogen receptor 1 Homo sapiens 125-127 22494775-8 2012 ERE-mediated activation by BPA and BPAF was via the AF-2 function of ERalpha, but Zea activated via both the AF-1 and AF-2 functions. 4,4'-hexafluorisopropylidene diphenol 35-39 estrogen receptor 1 Homo sapiens 69-76 22494775-10 2012 CONCLUSION: BPA and BPAF can function as EDCs by acting as cell type-specific agonists (>= 10 nM) or antagonists (<= 10 nM) for ERalpha and ERbeta. 4,4'-hexafluorisopropylidene diphenol 20-24 estrogen receptor 1 Homo sapiens 134-141