PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1383042-7 1992 At low sulfate content in the medium and in the presence of chlorate, the incorporation of sulfate and glucosamine was mainly into the low molecular-weight form of mucin. Sulfates 7-14 LOC100508689 Homo sapiens 164-169 17604678-7 2007 After metabolic labeling of NHBE cells, most of the secreted monomeric, high-molecular-mass [(35)S]sulphate-labelled molecules were immunoprecipitated with the OC125 antibody indicating that MUC16 is the major [(35)S]sulphate-labelled mucin in NHBE cell secretions. Sulfates 99-107 LOC100508689 Homo sapiens 235-240 12088546-8 2002 Mucin macromolecules are 70-80% carbohydrate, 20% protein, and 1-2% sulfate bound to oligosaccharide side chains. Sulfates 68-75 LOC100508689 Homo sapiens 0-5 11425799-11 2001 The reduced sulfate:glucosamine ratio was largely due to increased incorporation of glucosamine into newly synthesized mucin rather than reduction in total sulfate incorporation. Sulfates 12-19 LOC100508689 Homo sapiens 119-124 9218863-3 1997 At present this term can only be qualitatively related to the percentage of sulphate in the mucin molecule, which makes the term difficult to use in a biochemical and functional sense. Sulfates 76-84 LOC100508689 Homo sapiens 92-97 9071938-7 1997 Comparative staining with high iron diamine and biochemical analyses indicated that MAb 6G4 was reactive with mucin bearing sulphate or O-acetylated sialic acid groups, or both. Sulfates 124-132 LOC100508689 Homo sapiens 110-115 7622610-3 1995 The major mucin fraction isolated was characterized by a high hydroxy amino acid content (40%), a Thr/Ser ratio of 1.52, a high sialic acid content, and a low sulfate content. Sulfates 159-166 LOC100508689 Homo sapiens 10-15 7850844-1 1994 Mucin-sulphatase activity, measured using a 35S-[SO4(2-)]-labelled colonic mucin substrate, was detected in whole cells of Streptococci isolated from the human oral cavity. Sulfates 49-56 LOC100508689 Homo sapiens 0-5 7850844-1 1994 Mucin-sulphatase activity, measured using a 35S-[SO4(2-)]-labelled colonic mucin substrate, was detected in whole cells of Streptococci isolated from the human oral cavity. Sulfates 49-56 LOC100508689 Homo sapiens 75-80 8358229-5 1993 Metabolically labelled mucin isolated from UC patients contained less sulfate and had lower sialic acid O-acetylation compared with normal mucin. Sulfates 70-77 LOC100508689 Homo sapiens 23-28 1383042-7 1992 At low sulfate content in the medium and in the presence of chlorate, the incorporation of sulfate and glucosamine was mainly into the low molecular-weight form of mucin. Sulfates 91-98 LOC100508689 Homo sapiens 164-169 1383042-8 1992 An increase in sulfate in the medium caused an increase in the high molecular-weight form of mucin and in the extent of sulfation in its carbohydrate chain. Sulfates 15-22 LOC100508689 Homo sapiens 93-98 1383042-10 1992 The results suggest that the sulfation process is an early event taking place at the stage of mucin subunit assembly and that sulfate availability is essential for the formation of the high molecular-weight mucin polymer. Sulfates 126-133 LOC100508689 Homo sapiens 207-212 1590770-4 1992 Chemical analysis indicated that the putative palatal mucin was rich in sulphate, but poor in sialic acid. Sulfates 72-80 LOC100508689 Homo sapiens 54-59 3214155-8 1988 The reverse occurred upon the addition of mucin; sulfate reduction predominated and methanogenesis was completely inhibited. Sulfates 49-56 LOC100508689 Homo sapiens 42-47 1799374-3 1991 Titration data established that the inhibitory activity of mucin was associated with its acidic component as the fraction enriched in sialic acid and sulfate showed 16-fold higher inhibitory titer than that of the intact mucin. Sulfates 150-157 LOC100508689 Homo sapiens 59-64 3214155-9 1988 This was attributed to release of sulfate from the mucin which enabled SRB to outcompete methanogenic bacteria for H2. Sulfates 34-41 LOC100508689 Homo sapiens 51-56 3214155-12 1988 These data provide further evidence that sulfated polysaccharides such as mucin may be a source of sulfate for SRB in the human large gut. Sulfates 41-48 LOC100508689 Homo sapiens 74-79 2852666-7 1988 The sulphated mucopolysaccharides, chondroitin sulphate and mucin, strongly stimulated sulphide production in non-methanogenic faecal slurries only, suggesting that these substances may be a potential source of sulphate in the large gut. Sulfates 4-12 LOC100508689 Homo sapiens 60-65 6525608-5 1984 Based upon recoverable weight, the mucin was composed of 75% carbohydrate, 21% protein, and 3% sulfate. Sulfates 95-102 LOC100508689 Homo sapiens 35-40 3674885-1 1987 A high-molecular-weight mucin-glycoprotein (MG1) was isolated from human submandibular-sublingual saliva and was comprised of 14.9% protein, 29.0% N-acetylglucosamine, 9.4% N-acetylgalactosamine, 10.5% fucose, 24.2% galactose, 0.9% mannose, 4.0% N-acetylneuraminic acid, and 7.0% sulfate. Sulfates 280-287 LOC100508689 Homo sapiens 24-29 3002452-5 1985 However, the CF mucin contained substantially higher (11%) sulfate content than that observed for the asthmatic mucin (5.9%). Sulfates 59-66 LOC100508689 Homo sapiens 16-21 6192143-6 1983 Each mucin species was found to have a distinctive hexose, hexosamine, sialic acid, and sulfate content as well as blood group substance activities. Sulfates 88-95 LOC100508689 Homo sapiens 5-10 6833004-4 1983 (1) In the middle crypt, sulphate incorporation from the Golgi apparatus into the mucin droplets of the goblet cells was reduced in contrast with an increased uptake into the vesicles of the absorptive and "intermediate" cells. Sulfates 25-33 LOC100508689 Homo sapiens 82-87 6835717-9 1983 CF intestinal mucin was therefore denser and more highly glycosylated than nonCF musin and probably contained more sulfate. Sulfates 115-122 LOC100508689 Homo sapiens 14-19 13990365-0 1963 [Method for the demonstration of sialic and sulfate components of mucin]. Sulfates 44-51 LOC100508689 Homo sapiens 66-71 33090801-2 2020 However, this barrier is constantly challenged by mucin-degrading enzymes, which tend to target anionic glycan chains such as sulfate groups and sialic acid residues. Sulfates 126-133 LOC100508689 Homo sapiens 50-55 33090801-3 2020 Here, we demonstrate that the efficiency of both unspecific and specific binding of small molecules to mucins is reduced when sulfate groups are enzymatically removed from mucins; this is unexpected because neither of the specific mucin-binding partners tested here targets these sulfate motifs on the mucin glycoprotein. Sulfates 126-133 LOC100508689 Homo sapiens 103-108 33090801-3 2020 Here, we demonstrate that the efficiency of both unspecific and specific binding of small molecules to mucins is reduced when sulfate groups are enzymatically removed from mucins; this is unexpected because neither of the specific mucin-binding partners tested here targets these sulfate motifs on the mucin glycoprotein. Sulfates 126-133 LOC100508689 Homo sapiens 172-177 33090801-3 2020 Here, we demonstrate that the efficiency of both unspecific and specific binding of small molecules to mucins is reduced when sulfate groups are enzymatically removed from mucins; this is unexpected because neither of the specific mucin-binding partners tested here targets these sulfate motifs on the mucin glycoprotein. Sulfates 280-287 LOC100508689 Homo sapiens 103-108 33090801-3 2020 Here, we demonstrate that the efficiency of both unspecific and specific binding of small molecules to mucins is reduced when sulfate groups are enzymatically removed from mucins; this is unexpected because neither of the specific mucin-binding partners tested here targets these sulfate motifs on the mucin glycoprotein. Sulfates 280-287 LOC100508689 Homo sapiens 172-177