PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31704824-8 2019 RESULTS: The SPC-A1/DTX docetaxel-resistant lung adenocarcinoma cells were radio-resistant compared with the parental SPC-A1 cells. Docetaxel 24-33 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 13-19 27661766-6 2016 Next, klotho was overexpressed in drug-resistant cancer cell lines and the results showed that overexpression of klotho significantly inhibited cell proliferation of A549/DDP and SPC-A-1/DTX. Docetaxel 187-190 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 179-186 23255418-4 2013 In this study, it was observed that docetaxel-resistant human lung adenocarcinoma cell line (SPC-A1/DTX) was typical of mesenchymal phenotype. Docetaxel 36-45 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 93-103 25026294-5 2014 Here, we established two docetaxel-resistant LAD cell models (SPC-A1/DTX and H1299/DTX), and showed that miR-451 was significantly downregulated in docetaxel-resistant LAD cells. Docetaxel 25-34 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 62-68 25026294-5 2014 Here, we established two docetaxel-resistant LAD cell models (SPC-A1/DTX and H1299/DTX), and showed that miR-451 was significantly downregulated in docetaxel-resistant LAD cells. Docetaxel 148-157 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 62-68 26416454-2 2015 In the present study, an inverse correlation between miR-200b and autophagy-associated gene 12 (ATG12) expressions was observed in docetaxel-resistant (SPC-A1/DTX and H1299/DTX) and sensitive (SPC-A1 and H1299) LAD cells as well as in tissue samples. Docetaxel 131-140 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 152-158 26416454-2 2015 In the present study, an inverse correlation between miR-200b and autophagy-associated gene 12 (ATG12) expressions was observed in docetaxel-resistant (SPC-A1/DTX and H1299/DTX) and sensitive (SPC-A1 and H1299) LAD cells as well as in tissue samples. Docetaxel 131-140 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 193-199 24996221-7 2014 NOD/SCID mice were inoculated with docetaxel-resistant SPC-A1/DTX cells transfected with control or HMGB1 shRNA. Docetaxel 35-44 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 55-61 23562878-3 2013 Previously, docetaxel (DTX)-resistant LAD cell lines (SPC-A1/DTX and H1299/DTX) were established by our laboratory and displayed chemo- or radioresistance and mesenchymal features with enhanced invasiveness and motility. Docetaxel 12-21 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 54-60 23562878-3 2013 Previously, docetaxel (DTX)-resistant LAD cell lines (SPC-A1/DTX and H1299/DTX) were established by our laboratory and displayed chemo- or radioresistance and mesenchymal features with enhanced invasiveness and motility. Docetaxel 23-26 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 54-60 23255418-8 2013 Furthermore, inhibition of ZEB1 significantly enhanced the chemosensitivity of SPC-A1/DTX cells to docetaxel in vitro and in vivo and ectopic expression of ZEB1 increased the chemoresistance of SPC-A1 cells to docetaxel. Docetaxel 99-108 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 79-85 23255418-8 2013 Furthermore, inhibition of ZEB1 significantly enhanced the chemosensitivity of SPC-A1/DTX cells to docetaxel in vitro and in vivo and ectopic expression of ZEB1 increased the chemoresistance of SPC-A1 cells to docetaxel. Docetaxel 210-219 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 79-85 22460125-2 2012 To better elucidate the underlying molecular mechanisms involved in resistance to DTX-based chemotherapy, we established a DTX-resistant lung adenocarcinoma cell line (SPC-A1/DTX). Docetaxel 123-126 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 168-174 22460125-5 2012 Overexpression of ING4 reverses DTX or paclitaxel resistance of DTX-resistant lung adenocarcinoma cells (SPC-A1/DTX or A549/Taxol) by inducing apoptosis enhancement and G2/M arrest, and small interfering RNA-mediated ING4 knockdown renders DTX-sensitive lung adenocarcinoma cells more resistant to DTX or paclitaxel. Docetaxel 64-67 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 105-111 22460125-5 2012 Overexpression of ING4 reverses DTX or paclitaxel resistance of DTX-resistant lung adenocarcinoma cells (SPC-A1/DTX or A549/Taxol) by inducing apoptosis enhancement and G2/M arrest, and small interfering RNA-mediated ING4 knockdown renders DTX-sensitive lung adenocarcinoma cells more resistant to DTX or paclitaxel. Docetaxel 64-67 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 105-111 22460125-5 2012 Overexpression of ING4 reverses DTX or paclitaxel resistance of DTX-resistant lung adenocarcinoma cells (SPC-A1/DTX or A549/Taxol) by inducing apoptosis enhancement and G2/M arrest, and small interfering RNA-mediated ING4 knockdown renders DTX-sensitive lung adenocarcinoma cells more resistant to DTX or paclitaxel. Docetaxel 64-67 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 105-111 22460125-5 2012 Overexpression of ING4 reverses DTX or paclitaxel resistance of DTX-resistant lung adenocarcinoma cells (SPC-A1/DTX or A549/Taxol) by inducing apoptosis enhancement and G2/M arrest, and small interfering RNA-mediated ING4 knockdown renders DTX-sensitive lung adenocarcinoma cells more resistant to DTX or paclitaxel. Docetaxel 64-67 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 105-111 22460125-6 2012 Also, overexpression of ING4 could enhance the in vivo sensitivity of SPC-A1/DTX cells to DTX. Docetaxel 90-93 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 70-76 22460125-2 2012 To better elucidate the underlying molecular mechanisms involved in resistance to DTX-based chemotherapy, we established a DTX-resistant lung adenocarcinoma cell line (SPC-A1/DTX). Docetaxel 123-126 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 168-174 22139708-4 2012 RESULTS: Based on miRNA microarray data, miR-200b was identified as the most down-regulated miRNA in docetaxel-resistant SPC-A1/DTX cells compared with parental SPC-A1 cells. Docetaxel 101-110 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 121-127 22139708-6 2012 In a nude mouse xenograft model, up-regulation of miR-200b significantly enhanced response of SPC-A1/DTX cells to docetaxel. Docetaxel 114-123 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 94-100 22139708-4 2012 RESULTS: Based on miRNA microarray data, miR-200b was identified as the most down-regulated miRNA in docetaxel-resistant SPC-A1/DTX cells compared with parental SPC-A1 cells. Docetaxel 101-110 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 161-167 22120675-0 2012 MiR-100 resensitizes docetaxel-resistant human lung adenocarcinoma cells (SPC-A1) to docetaxel by targeting Plk1. Docetaxel 21-30 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 74-80 22120675-0 2012 MiR-100 resensitizes docetaxel-resistant human lung adenocarcinoma cells (SPC-A1) to docetaxel by targeting Plk1. Docetaxel 85-94 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 74-80 22120675-2 2012 By microarray analysis, miR-100 was found significantly down-regulated in docetaxel-resistant SPC-A1/DTX cells compared with parental SPC-A1 cells. Docetaxel 74-83 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 94-100 22120675-2 2012 By microarray analysis, miR-100 was found significantly down-regulated in docetaxel-resistant SPC-A1/DTX cells compared with parental SPC-A1 cells. Docetaxel 74-83 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 134-140 22120675-3 2012 Ectopic miR-100 expression resensitized SPC-A1/DTX cells to docetaxel by suppression of cell proliferation and induction of cell arrest in G(2)/M phase and apoptosis. Docetaxel 60-69 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 40-46 23035364-5 2012 Accordingly, SPC-A1/DTX cells were approximately 13.7 times resistant to DTX than SPC-A1 cells. Docetaxel 73-76 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 13-19 23035364-6 2012 The combined therapy of h-R3 and DTX showed strong synergistic suppressive effect on cell proliferation of SPC-A1/DTX cells in vitro. Docetaxel 33-36 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 107-113 23035364-6 2012 The combined therapy of h-R3 and DTX showed strong synergistic suppressive effect on cell proliferation of SPC-A1/DTX cells in vitro. Docetaxel 114-117 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 107-113 23035364-10 2012 Moreover, when combined with DTX, h-R3 brought higher apoptosis rate in SPC-A1/DTX cells rather than in SPC-A1 cells. Docetaxel 29-32 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 72-78 19243251-1 2009 OBJECTIVE: The aim of this study was to investigate the inhibitory effects of cytokine-induced killer (CIK) cells combined with docetaxel (DTX) on the growth of drug-resistant lung adenocarcinoma cell line SPC-A1/DTX in vitro and in vivo. Docetaxel 139-142 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 206-212 21569641-0 2011 [Sequence-dependent effect of docetaxel with gefitinib on the proliferation and signal protein expression of human lung adenocarcinoma cell SPC-A1]. Docetaxel 30-39 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 140-146 19900214-0 2010 Identification of microRNA profiles in docetaxel-resistant human non-small cell lung carcinoma cells (SPC-A1). Docetaxel 39-48 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 102-108 19900214-4 2010 Here, microarray chip technology was employed to identify miRNA expression profiles in docetaxel-resistant human NSCLC cell line (SPC-A1/docetaxel). Docetaxel 87-96 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 130-136 19900214-4 2010 Here, microarray chip technology was employed to identify miRNA expression profiles in docetaxel-resistant human NSCLC cell line (SPC-A1/docetaxel). Docetaxel 137-146 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 130-136 19900214-7 2010 The expression of a total of 52 miRNAs showed significant difference between SPC-A1/docetaxel cells and control SPC-A1 cells (P < 0.01). Docetaxel 84-93 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 77-83 19900214-9 2010 The expression of three miRNAs (miR-200b, 194 and 212) was significantly down-regulated in SPC-A1/docetaxel cells, while the expression of other three miRNAs (miR-192, 424 and 98) was significantly up-regulated in SPC-A1/docetaxel cells (P < 0.01). Docetaxel 98-107 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 91-97 19900214-9 2010 The expression of three miRNAs (miR-200b, 194 and 212) was significantly down-regulated in SPC-A1/docetaxel cells, while the expression of other three miRNAs (miR-192, 424 and 98) was significantly up-regulated in SPC-A1/docetaxel cells (P < 0.01). Docetaxel 221-230 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 91-97 19900214-11 2010 The expression of a few target genes in SPC-A1/docetaxel and SPC-A1 cells were further confirmed by qRT-PCR and Western blot. Docetaxel 47-56 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 40-46 19243251-2 2009 METHODS: The MTT assay was employed to evaluate the cytotoxic activity of DTX, CIK cells, and DTX plused CIK cells against SPC-A1/DTX cells in vitro. Docetaxel 74-77 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 123-129 19243251-2 2009 METHODS: The MTT assay was employed to evaluate the cytotoxic activity of DTX, CIK cells, and DTX plused CIK cells against SPC-A1/DTX cells in vitro. Docetaxel 94-97 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 123-129 19243251-2 2009 METHODS: The MTT assay was employed to evaluate the cytotoxic activity of DTX, CIK cells, and DTX plused CIK cells against SPC-A1/DTX cells in vitro. Docetaxel 94-97 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 123-129 21126400-0 2007 [Screening differential expression of docetaxel-resistance related genes of human lung adenocarcinoma cell line SPC-A1 by cDNA microarray]. Docetaxel 38-47 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 112-118 21126400-2 2007 The aim of this study is to screen differentially expressed genes of docetaxel resistant cell line SPC-A1/Docetaxel and its parent cell line SPC-A1 with gene chip technique. Docetaxel 69-78 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 99-105 21126400-2 2007 The aim of this study is to screen differentially expressed genes of docetaxel resistant cell line SPC-A1/Docetaxel and its parent cell line SPC-A1 with gene chip technique. Docetaxel 69-78 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 141-147 21126400-2 2007 The aim of this study is to screen differentially expressed genes of docetaxel resistant cell line SPC-A1/Docetaxel and its parent cell line SPC-A1 with gene chip technique. Docetaxel 106-115 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 99-105 21126400-2 2007 The aim of this study is to screen differentially expressed genes of docetaxel resistant cell line SPC-A1/Docetaxel and its parent cell line SPC-A1 with gene chip technique. Docetaxel 106-115 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 141-147 21126400-9 2007 CONCLUSIONS: These differentially expressed genes may be related to the mechanisms of docetaxel resistance in SPC-A1/Docetaxel cell line. Docetaxel 86-95 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 110-116 21126400-9 2007 CONCLUSIONS: These differentially expressed genes may be related to the mechanisms of docetaxel resistance in SPC-A1/Docetaxel cell line. Docetaxel 117-126 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 110-116