PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16203790-15	2005	The results also show induction of previously undescribed metabolic pathways for docetaxel, one of which may be analogous to the known 6-alpha-hydroxylation of paclitaxel by CYP2C8.	Docetaxel	81-90	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	174-180	
9322876-4	1997	The drugs both undergo hepatic metabolism; however, the specific cytochrome P-450 (CYP) enzymes responsible for hydroxylation are CYP 2C8 for paclitaxel and CYP 3A4 for docetaxel.	Docetaxel	169-178	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	130-137	
11901098-2	2002	In spite of their close chemical structure, the two drugs are oxidized by two different enzymes; CYP2C8 catalyzes the 6-hydroxylation on the taxane ring of paclitaxel, whereas CYP3A4 oxidizes docetaxel on the tert-butyl group of the lateral chain in C13.	Docetaxel	192-201	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	97-103	
11901098-6	2002	The presence of a tert-butyl group in the lateral chain of docetaxel favored the hydroxylation on the tert-butyl by CYP3A4, whereas the presence of a phenyl group in the lateral chain facilitated the oxidation on the taxane ring by CYP2C8.	Docetaxel	59-68	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	232-238	
11549208-7	2001	In addition, the higher levels of CsA with docetaxel than with paclitaxel co-administration may be explained by the fact that docetaxel is almost exclusively metabolised by CYP 3A4, whereas paclitaxel is predominantly metabolised by CYP 2C8 and to a lesser extent by CYP 3A4.	Docetaxel	43-52	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	233-240	
11549208-7	2001	In addition, the higher levels of CsA with docetaxel than with paclitaxel co-administration may be explained by the fact that docetaxel is almost exclusively metabolised by CYP 3A4, whereas paclitaxel is predominantly metabolised by CYP 2C8 and to a lesser extent by CYP 3A4.	Docetaxel	126-135	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	233-240