PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22426195-2	2013	A potential drug-drug interaction exists between docetaxel and ketoconazole because both agents are metabolized hepatically by the cytochrome P-450 system, and ketoconazole can inhibit p-gp efflux of docetaxel at blood brain barrier.	Docetaxel	49-58	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	131-147	
16022919-1	2005	To clarify the role of cytochrome P450 in docetaxel and cisplatin combination chemotherapy, cytochrome P450 activity was measured by simple antipyrine test, and its correlation with the drugs" pharmacodynamics was assessed.	Docetaxel	42-51	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	23-38	
22426923-3	2012	PATIENTS AND METHODS: 79 SNPs in CYP450, whose minor allele frequency were >= 10%, were genotyped in 69 MBC patients who were treated with docetaxel plus capecitabine.	Docetaxel	142-151	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	33-39	
21626050-0	2012	Docetaxel pharmacokinetics and its correlation with two in vivo probes for cytochrome P450 enzymes: the C(14)-erythromycin breath test and the antipyrine clearance test.	Docetaxel	0-9	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	75-90	
16022919-9	2005	We concluded that antipyrine test and cytochrome P450 play an important role in predicting toxicities of docetaxel and cisplatin combination chemotherapy.	Docetaxel	105-114	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	38-53	
11102737-15	2000	The taxanes paclitaxel and docetaxel are considered excellent substrate drugs to test the concept that by inhibition of P-gp in the gut wall and CYP activity in gut wall and/or liver low oral bioavailability can be increased substantially.	Docetaxel	27-36	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	145-148	
9322876-4	1997	The drugs both undergo hepatic metabolism; however, the specific cytochrome P-450 (CYP) enzymes responsible for hydroxylation are CYP 2C8 for paclitaxel and CYP 3A4 for docetaxel.	Docetaxel	169-178	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	65-81	
9825831-2	1998	To determine which cytochrome P450 is involved in taxotere biotransformation, 11 cDNA-expressed human cytochrome P450s were examined for their activity in the metabolism of taxotere and its derivatives.	Docetaxel	50-58	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	19-34	
9825831-2	1998	To determine which cytochrome P450 is involved in taxotere biotransformation, 11 cDNA-expressed human cytochrome P450s were examined for their activity in the metabolism of taxotere and its derivatives.	Docetaxel	50-58	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	102-117	
9825831-2	1998	To determine which cytochrome P450 is involved in taxotere biotransformation, 11 cDNA-expressed human cytochrome P450s were examined for their activity in the metabolism of taxotere and its derivatives.	Docetaxel	173-181	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	19-34	
9825831-2	1998	To determine which cytochrome P450 is involved in taxotere biotransformation, 11 cDNA-expressed human cytochrome P450s were examined for their activity in the metabolism of taxotere and its derivatives.	Docetaxel	173-181	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	102-117	
9322876-4	1997	The drugs both undergo hepatic metabolism; however, the specific cytochrome P-450 (CYP) enzymes responsible for hydroxylation are CYP 2C8 for paclitaxel and CYP 3A4 for docetaxel.	Docetaxel	169-178	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	83-86