PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28133913-5 2017 siRNA manipulation of ZEB1 and ZEB2 in PC-3 and DU145 docetaxel-resistant sublines identified ZEB1, through its transcriptional repression of E-cadherin, to be a driver of both EMT and docetaxel resistance. Docetaxel 54-63 cadherin 1 Homo sapiens 142-152 31452801-12 2019 Reverse transcription-quantitative PCR analysis performed on docetaxel-sensitive and docetaxel-resistant prostate cancer cell lines demonstrated that certain hub genes, including CDK1, 2"-5"-oligoadenylate synthetase 3, CXCL8 and CDH1, were highly expressed in the docetaxel-resistant cell lines, which confirmed the bioinformatics results. Docetaxel 61-70 cadherin 1 Homo sapiens 230-234 31452801-12 2019 Reverse transcription-quantitative PCR analysis performed on docetaxel-sensitive and docetaxel-resistant prostate cancer cell lines demonstrated that certain hub genes, including CDK1, 2"-5"-oligoadenylate synthetase 3, CXCL8 and CDH1, were highly expressed in the docetaxel-resistant cell lines, which confirmed the bioinformatics results. Docetaxel 85-94 cadherin 1 Homo sapiens 230-234 31452801-12 2019 Reverse transcription-quantitative PCR analysis performed on docetaxel-sensitive and docetaxel-resistant prostate cancer cell lines demonstrated that certain hub genes, including CDK1, 2"-5"-oligoadenylate synthetase 3, CXCL8 and CDH1, were highly expressed in the docetaxel-resistant cell lines, which confirmed the bioinformatics results. Docetaxel 85-94 cadherin 1 Homo sapiens 230-234 28133913-7 2017 This study presents evidence for a role of ZEB1, through its transcriptional repression of E-cadherin to be a driver of both EMT and docetaxel resistance in docetaxel-resistant prostate cancer. Docetaxel 133-142 cadherin 1 Homo sapiens 91-101 28133913-7 2017 This study presents evidence for a role of ZEB1, through its transcriptional repression of E-cadherin to be a driver of both EMT and docetaxel resistance in docetaxel-resistant prostate cancer. Docetaxel 157-166 cadherin 1 Homo sapiens 91-101 25279705-10 2014 Taken together, the HDAC1/miR-200b/Suz-12-E-cadherin signaling might account for maintenance of CSCs and formation of chemoresistant phenotype in docetaxel-resistant LAD cells. Docetaxel 146-155 cadherin 1 Homo sapiens 42-52 22027694-11 2012 Analysis in patients showed a noteworthy downexpression of CDH1 and IFIH1, among others, in docetaxel-resistant tumors. Docetaxel 92-101 cadherin 1 Homo sapiens 59-63 23041061-4 2012 In this study, we report that docetaxel-resistant cells underwent an epithelial-to-mesenchymal transition during the selection process, leading to diminished E-cadherin levels and up-regulation of mesenchymal markers. Docetaxel 30-39 cadherin 1 Homo sapiens 158-168 34281228-10 2021 Combined treatment led to high-efficacy effects on MCF-7 cells, which were associated to the up-regulation of CDKN1A, BAX, caspase 9 and E-cadherin mRNA under combined treatment compared to single DOCE treatment. Docetaxel 197-201 cadherin 1 Homo sapiens 137-147 9066624-0 1997 Docetaxel enhances the expression of E-cadherin and carcinoembryonic antigen (CEA) on human colon cancer cell lines in vitro. Docetaxel 0-9 cadherin 1 Homo sapiens 37-47 9066624-2 1997 Docetaxel was shown to increase the expression of E-cadherin and CEA in the low concentration range of 3 x 10(-10) M - 3 x 10(-9) M for HT-29 cells and 0.6 - 3 x 10(-9) M for SW620 cells. Docetaxel 0-9 cadherin 1 Homo sapiens 50-60 9066624-3 1997 Docetaxel strongly increased CEA (270%) and E-cadherin (160%) expression in HT-29 cells, compared with both marker expression in SW620 cells (60%). Docetaxel 0-9 cadherin 1 Homo sapiens 44-54 9066624-4 1997 E-cadherin and CEA expression were found to be inversely correlated to the antiproliferating potential of docetaxel, which inhibits the cell proliferation of HT-29 cells at an IC50 of 6 x 10(-10) M and of SW620 cells at 8 x 10(-10) M. The data suggest, that in addition to its antiproliferative activity docetaxel also exhibits a strong differentiation inducing capacity at concentrations < 10(-9) M in vitro. Docetaxel 106-115 cadherin 1 Homo sapiens 0-10 9066624-4 1997 E-cadherin and CEA expression were found to be inversely correlated to the antiproliferating potential of docetaxel, which inhibits the cell proliferation of HT-29 cells at an IC50 of 6 x 10(-10) M and of SW620 cells at 8 x 10(-10) M. The data suggest, that in addition to its antiproliferative activity docetaxel also exhibits a strong differentiation inducing capacity at concentrations < 10(-9) M in vitro. Docetaxel 304-313 cadherin 1 Homo sapiens 0-10