PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34638338-5 2021 STAT1 and STAT3 are involved in docetaxel resistance, while STAT3 and STAT5 are involved in antiandrogen resistance. Docetaxel 32-41 signal transducer and activator of transcription 3 Homo sapiens 10-15 34268250-0 2021 Quercetin Synergistically Enhances the Anticancer Efficacy of Docetaxel through Induction of Apoptosis and Modulation of PI3K/AKT, MAPK/ERK, and JAK/STAT3 Signaling Pathways in MDA-MB-231 Breast Cancer Cell Line. Docetaxel 62-71 signal transducer and activator of transcription 3 Homo sapiens 149-154 34445110-8 2021 Moreover, SH003 and DTX induced the apoptosis of H460 cells via the suppression of the EGFR and signal transducer and activator of transcription 3 (STAT3) signaling pathways. Docetaxel 20-23 signal transducer and activator of transcription 3 Homo sapiens 96-146 34445110-8 2021 Moreover, SH003 and DTX induced the apoptosis of H460 cells via the suppression of the EGFR and signal transducer and activator of transcription 3 (STAT3) signaling pathways. Docetaxel 20-23 signal transducer and activator of transcription 3 Homo sapiens 148-153 34445110-9 2021 In H460 tumor xenograft models, the administration of SH003 or docetaxel alone diminished tumor growth, and their combination effectively killed cancer cells, with increased expression of apoptotic markers and decreased expression of p-EGFR and p-STAT3. Docetaxel 63-72 signal transducer and activator of transcription 3 Homo sapiens 247-252 29844001-0 2018 Docetaxel Down-Regulates PD-1 Expression via STAT3 in T Lymphocytes. Docetaxel 0-9 signal transducer and activator of transcription 3 Homo sapiens 45-50 35437196-0 2022 Corrigendum to "Docetaxel downregulates PD-1 expression via STAT3 in Tlymphocytes" (Clinical Lung Cancer 19 (2018) e675-e683). Docetaxel 16-25 signal transducer and activator of transcription 3 Homo sapiens 60-65 35234310-7 2022 Moreover, the combinations treatment of CLG and docetaxel markedly inhibited cell growth, phosphorylation of JAK-Src-STAT3 and induced substantial apoptosis. Docetaxel 48-57 signal transducer and activator of transcription 3 Homo sapiens 117-122 30171201-0 2019 Acetyl-11-keto-beta-boswellic acid suppresses docetaxel-resistant prostate cancer cells in vitro and in vivo by blocking Akt and Stat3 signaling, thus suppressing chemoresistant stem cell-like properties. Docetaxel 46-55 signal transducer and activator of transcription 3 Homo sapiens 129-134 30171201-10 2019 In summary, we demonstrate that AKBA inhibits the growth inhibition of docetaxel-resistant PCa cells in vitro and in vivo via blocking Akt and Stat3 signaling, thus suppressing their cancer stem cell-like properties. Docetaxel 71-80 signal transducer and activator of transcription 3 Homo sapiens 143-148 31285646-1 2019 Epidermal Growth Factor Receptor (EGFR) is, for the most part, deregulated and over-communicated in ovarian disease, which is legitimately connected with STAT3 enactment that prompts the collection of hostile to apoptotic occasions and along these lines, docetaxel medicate obstruction happens. Docetaxel 255-264 signal transducer and activator of transcription 3 Homo sapiens 154-159 29844001-11 2018 Further tests in Jurkat T cells demonstrated that docetaxel activated signal transduction and activator of transcription 3 (STAT3) signaling to suppress PD-1 expression, whereas STAT3 inhibition reversed the down-regulation of PD-1. Docetaxel 50-59 signal transducer and activator of transcription 3 Homo sapiens 70-122 29844001-11 2018 Further tests in Jurkat T cells demonstrated that docetaxel activated signal transduction and activator of transcription 3 (STAT3) signaling to suppress PD-1 expression, whereas STAT3 inhibition reversed the down-regulation of PD-1. Docetaxel 50-59 signal transducer and activator of transcription 3 Homo sapiens 124-129 28578456-0 2017 Sequential combination of docetaxel with a SHP-1 agonist enhanced suppression of p-STAT3 signaling and apoptosis in triple negative breast cancer cells. Docetaxel 26-35 signal transducer and activator of transcription 3 Homo sapiens 83-88 29246644-0 2018 Docetaxel-mediated autophagy promotes chemoresistance in castration-resistant prostate cancer cells by inhibiting STAT3. Docetaxel 0-9 signal transducer and activator of transcription 3 Homo sapiens 114-119 29246644-4 2018 Meanwhile, docetaxel induced autophagy was inhibited by STAT3 activation, which increased mitochondrial damage and decreased CRPC cell viability. Docetaxel 11-20 signal transducer and activator of transcription 3 Homo sapiens 56-61 28578456-17 2017 Docetaxel combined with SC-43 enhances cell apoptosis and reduces p-STAT3. Docetaxel 0-9 signal transducer and activator of transcription 3 Homo sapiens 68-73 28578456-6 2017 Sequential combination of docetaxel and SC-43 in vitro showed enhanced anti-proliferation and apoptosis associated with decreased p-STAT3 and decreased STAT3-downstream effector cyclin D1 in the TNBC cell lines MDA-MB-231, MDA-MB-468, and HCC-1937. Docetaxel 26-35 signal transducer and activator of transcription 3 Homo sapiens 132-137 28578456-6 2017 Sequential combination of docetaxel and SC-43 in vitro showed enhanced anti-proliferation and apoptosis associated with decreased p-STAT3 and decreased STAT3-downstream effector cyclin D1 in the TNBC cell lines MDA-MB-231, MDA-MB-468, and HCC-1937. Docetaxel 26-35 signal transducer and activator of transcription 3 Homo sapiens 152-157 28578456-11 2017 Our results suggest that the novel SHP-1 agonist SC-43 enhanced docetaxel-induced cytotoxicity by SHP-1 dependent STAT3 inhibition in human triple negative breast cancer cells. Docetaxel 64-73 signal transducer and activator of transcription 3 Homo sapiens 114-119 28578456-13 2017 Docetaxel combined with SC-43 enhances cell apoptosis and reduces p-STAT3. Docetaxel 0-9 signal transducer and activator of transcription 3 Homo sapiens 68-73 28553168-11 2017 The combination of low-dose docetaxel and YK-4-279 caused a stronger decrease in the levels of ETV1, AR, PSA, p-STAT3, survivin, Bcl-2, and p-Akt in LNCaP cells and of p-Akt, Bcl-2, and p-STAT3 in PC-3 cells compared with either drug alone. Docetaxel 28-37 signal transducer and activator of transcription 3 Homo sapiens 112-117 28553168-11 2017 The combination of low-dose docetaxel and YK-4-279 caused a stronger decrease in the levels of ETV1, AR, PSA, p-STAT3, survivin, Bcl-2, and p-Akt in LNCaP cells and of p-Akt, Bcl-2, and p-STAT3 in PC-3 cells compared with either drug alone. Docetaxel 28-37 signal transducer and activator of transcription 3 Homo sapiens 188-193 19578780-6 2009 Furthermore, we found that inhibition of STAT 3 signaling by Serenoa repens or Janus family of tyrosine kinase (JAK) inhibitor of AG490 enhanced the ability of docetaxel to inhibit the growth of U266 and RPMI 8226 cells, as measured by trypan blue exclusion test. Docetaxel 160-169 signal transducer and activator of transcription 3 Homo sapiens 41-47 28084011-8 2017 The use of SC-60 in combination with docetaxel synergized the anticancer effect induced by SC-60 through the SHP-1/STAT3 pathway in TNBC cells. Docetaxel 37-46 signal transducer and activator of transcription 3 Homo sapiens 115-120 18426800-7 2008 The PIM1 kinase plays a critical role in this STAT3 --> PIM1 --> NFkappaB stress response pathway and serves as a target for intervention to enhance the therapeutic effects of cytotoxic drugs such as docetaxel. Docetaxel 206-215 signal transducer and activator of transcription 3 Homo sapiens 46-51 18426800-4 2008 Docetaxel activates STAT3 phosphorylation and transcriptional activity, which in turns induces expression of the PIM1 gene, encoding a serine-threonine kinase activated by many cellular stresses. Docetaxel 0-9 signal transducer and activator of transcription 3 Homo sapiens 20-25