PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23019417-5 2012 In addition, apicidin and docetaxel co-treatment specifically stimulates apoptosis, characterized by an increased Bax/Bcl-2 ratio and caspase-8 activation. Docetaxel 26-35 caspase 8 Homo sapiens 134-143 34549714-1 2021 OBJECTIVE: To investigate the effect of DR5-mediated docetaxel-targeted lipid microbubbles (MBs) combined with ultrasound-targeted microbubble destruction on apoptosis and expressions of Bcl-2, nuclear factor-kappaB(NF-kappaB), caspase-8, and DR5 in human HepG2 cells. Docetaxel 53-62 caspase 8 Homo sapiens 228-237 30937691-1 2019 The blots of control and docetaxel for caspase-9, caspase-3, caspase-8, Bcl-XL, and tubulin in the Figure 4f were reused from Figure 4 of our previous paper published in Journal of Urology in 2010 ( https://doi.org/10.1016/j.juro.2010.07.035 ). Docetaxel 25-34 caspase 8 Homo sapiens 61-70 30519344-6 2018 In vivo, ZD55-IL-24 and DTX synergistically inhibited the growth and activated the apoptosis of DU145 xenografts, accompanied by significantly decreased PARP-1 levels and increased caspase-3 and caspase-8 levels as well as decreased CD31 expression. Docetaxel 24-27 caspase 8 Homo sapiens 195-204 25216531-5 2014 Apollon knockdown also enhanced cisplatin/docetaxel-induced activation of caspase-8 (extrinsic pathway) and caspase-9 (intrinsic pathway) in ESCC cells and xenograft tumor models. Docetaxel 42-51 caspase 8 Homo sapiens 74-83 27465556-0 2016 Fibronectin protects lung cancer cells against docetaxel-induced apoptosis by promoting Src and caspase-8 phosphorylation. Docetaxel 47-56 caspase 8 Homo sapiens 96-105 27465556-3 2016 Subsequently, we showed that fibronectin pretreatment could enhance cell viability and reduce apoptosis in docetaxel-treated lung cancer cells because fibronectin induced phosphorylated Src and caspase-8, rendering the later inactive, thus inhibiting docetaxel-induced apoptosis. Docetaxel 107-116 caspase 8 Homo sapiens 194-203 27465556-7 2016 Inhibition of phospho-Src reduced phospho-caspase-8 and promoted caspase-8 activity, restoring apoptosis following docetaxel and fibronectin co-treatment. Docetaxel 115-124 caspase 8 Homo sapiens 42-51 27465556-7 2016 Inhibition of phospho-Src reduced phospho-caspase-8 and promoted caspase-8 activity, restoring apoptosis following docetaxel and fibronectin co-treatment. Docetaxel 115-124 caspase 8 Homo sapiens 65-74 27465556-9 2016 Our findings indicate that fibronectin promotes Src and caspase-8 phosphorylation in lung cancer cells, which decreases caspase-8 activation and protects tumor cells from docetaxel-induced apoptosis. Docetaxel 171-180 caspase 8 Homo sapiens 56-65 27465556-10 2016 Therefore, the fibronectin/Src/caspase-8 pathway may play a crucial role in docetaxel resistance in lung cancer. Docetaxel 76-85 caspase 8 Homo sapiens 31-40 16361572-10 2005 Caspase-3 and caspase-8 activity also increased significantly in docetaxel-treated SKOV3 and HeyA8 cells but not in the taxane-resistant cells. Docetaxel 65-74 caspase 8 Homo sapiens 14-23 17505004-8 2007 Docetaxel mainly induced caspase-8 activation, whereas the addition of celecoxib and ZD1839 augmented the caspase-8 activation and enhanced caspase-9 activation. Docetaxel 0-9 caspase 8 Homo sapiens 25-34 22572929-0 2012 FG020326 sensitized multidrug resistant cancer cells to docetaxel-mediated apoptosis via enhancement of caspases activation. Docetaxel 56-65 caspase 8 Homo sapiens 104-112 22572929-3 2012 Functional P-gp can confer resistance to activate caspase-8 and -3 dependent apoptosis induced by a range of different stimuli, including tumor necrosis and chemotherapeutic drugs such as docetaxel and vincristine. Docetaxel 188-197 caspase 8 Homo sapiens 50-66 22572929-6 2012 Therefore, the enhancement of caspase-8, -9 and -3 activation induced by docetaxel may be one of the key mechanisms of the reversal of P-gp mediated docetaxel resistance by FG020326. Docetaxel 73-82 caspase 8 Homo sapiens 30-50 22572929-6 2012 Therefore, the enhancement of caspase-8, -9 and -3 activation induced by docetaxel may be one of the key mechanisms of the reversal of P-gp mediated docetaxel resistance by FG020326. Docetaxel 149-158 caspase 8 Homo sapiens 30-50 17308071-9 2007 Activation of caspase-8 and Bid seemed to be a late event, and docetaxel was able to induce apoptosis in cells deficient in caspase-8 and Bid. Docetaxel 63-72 caspase 8 Homo sapiens 124-133 15566641-0 2004 [Enhancement of FG020326 on sensitivity of MCF-7/ADR cells to taxotere via enhancing activation of caspase-8 and caspase-3]. Docetaxel 62-70 caspase 8 Homo sapiens 99-108 16080463-6 2005 Caspase 8 and 9 activities were measured in cells overexpressing Bcl-xL or c-FLIP exposed to docetaxel and paclitaxel using fluorescent substrate cleavage assay. Docetaxel 93-102 caspase 8 Homo sapiens 0-9 15566641-11 2004 Activities of caspase-3 and caspase-8 in MCF-7/ADR cells cultured with 10 micromol/L FG020326 and 0.1 micromol/L taxotere were increased in a time-dependent manner,and reached peak values at 48 h, which were significantly higher than those in cells cultured with taxotere alone. Docetaxel 113-121 caspase 8 Homo sapiens 28-37 15566641-11 2004 Activities of caspase-3 and caspase-8 in MCF-7/ADR cells cultured with 10 micromol/L FG020326 and 0.1 micromol/L taxotere were increased in a time-dependent manner,and reached peak values at 48 h, which were significantly higher than those in cells cultured with taxotere alone. Docetaxel 263-271 caspase 8 Homo sapiens 28-37 15566641-12 2004 CONCLUSION: FG020326 may reverse drug-resistance of MCF-7/ADR cells towards taxotere through enhancing activation of caspase-8 and caspase-3 induced by taxotere. Docetaxel 152-160 caspase 8 Homo sapiens 117-126