PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1867835-2	1991	Cerebral levodopa kinetics in the rhesus monkey were investigated after the inhibition of catechol-O-methyltransferase (COMT) with RO 40-7592, and after coadministration of the peripheral aromatic L-amino acid decarboxylase (AADC) inhibitors benserazide and carbidopa.	Tolcapone	131-141	catechol-O-methyltransferase	Macaca mulatta	90-118	
1536715-5	1992	After pretreatment of the monkeys with the peripherally and centrally active catecholamine-O-methyl transferase (COMT) inhibitor Ro 40-7592 10 mg/kg, the decarboxylation rate remained unchanged (0.0112 +/- 0.0015 min-1) for (beta-11C)-L-dopa, whereas an increase in rate was measured for 6-fluoro-(beta-11C)-L-dopa (0.0092 +/- 0.0015 min-1).	Tolcapone	129-139	catechol-O-methyltransferase	Macaca mulatta	77-111	
1536715-5	1992	After pretreatment of the monkeys with the peripherally and centrally active catecholamine-O-methyl transferase (COMT) inhibitor Ro 40-7592 10 mg/kg, the decarboxylation rate remained unchanged (0.0112 +/- 0.0015 min-1) for (beta-11C)-L-dopa, whereas an increase in rate was measured for 6-fluoro-(beta-11C)-L-dopa (0.0092 +/- 0.0015 min-1).	Tolcapone	129-139	catechol-O-methyltransferase	Macaca mulatta	113-117	
1867835-2	1991	Cerebral levodopa kinetics in the rhesus monkey were investigated after the inhibition of catechol-O-methyltransferase (COMT) with RO 40-7592, and after coadministration of the peripheral aromatic L-amino acid decarboxylase (AADC) inhibitors benserazide and carbidopa.	Tolcapone	131-141	catechol-O-methyltransferase	Macaca mulatta	120-124	
9365014-6	1997	All three COMT inhibitors reduced the FDOPA methylation rate constant in plasma, with complete suppression obtained in the case of Ro 40-7592.	Tolcapone	131-141	catechol-O-methyltransferase	Macaca mulatta	10-14	
9175615-2	1997	Each animal was studied twice: with and without pretreatment of the catechol-O-methyltransferase (COMT) inhibitor Ro 40-7592, tolcapone.	Tolcapone	114-124	catechol-O-methyltransferase	Macaca mulatta	98-102	
9175615-6	1997	It is concluded that the COMT inhibitor tolcapone exhibits clear peripheral and central activity.	Tolcapone	40-49	catechol-O-methyltransferase	Macaca mulatta	25-29