PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16946132-4	2006	Oral treatment with GW3965 increased the expression of ABCA1 by approximately 6-fold (P=0.004) as well as other LXR target genes in the intestines of mice, with no change in the hepatic expression of these genes.	GW 3965	20-26	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	55-60	
34564456-3	2021	We tested whether treating cultured immortalized mouse aortic endothelial cells (iMAEC) with the endogenous LXR agonist 22(R)-hydroxycholesterol, synthetic LXR agonist GW3965, endogenous RXR agonist 9-cis-retinoic acid, or synthetic RXR agonist SR11237 increases ABCA1 protein expression.	GW 3965	168-174	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	263-268	
15145986-6	2004	Herein, we demonstrate that plasma HDL-C elevation and intestinal ABCA1 induction can occur with relatively little induction of FAS and SREBP1-c in mouse liver via a selective LXR modulator GW3965.	GW 3965	190-196	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	66-71	
34564456-4	2021	We observed a significant increase in ABCA1 protein expression in iMAEC treated with either GW3965 or SR11237 alone, but no significant increase in ABCA1 protein was observed in iMAEC treated with either 22(R)-hydroxycholesterol or 9-cis-retionic acid alone.	GW 3965	92-98	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	38-43	
34564456-5	2021	However, we observed significant increases in both ABCA1 protein expression and apoAI-mediated cholesterol efflux when iMAEC were treated with a combination of either 22(R)-hydroxycholesterol and 9-cis-retinoic acid or GW3965 and SR11237.	GW 3965	219-225	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	51-56	
33785343-13	2021	Mechanistically, GW3965 activated LXRbeta and its downstream target ABCA1 to initiate the apoptosis of spleen MDSCs.	GW 3965	17-23	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	68-73	
28028143-0	2017	ABCA1/ApoE/HDL Pathway Mediates GW3965-Induced Neurorestoration After Stroke.	GW 3965	32-38	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	0-5	
28028143-5	2017	The current study investigates whether ABCA1/ApoE/HDL pathway mediates GW3965, a synthetic dual liver-X receptor agonist, induced neurorestoration after stroke.	GW 3965	71-77	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	39-44	
26720273-4	2015	The data suggests that the LXR agonist GW3965 is associated with increased expression of ApoE and ABCA1 in the hippocampus and cerebral cortex without a detectable reduction of the amyloid load.	GW 3965	39-45	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	98-103	
21889608-7	2012	Additionally, treatment of symptomatic AD mice with GW3965, an LXR agonist that stimulates ABCA1 expression, increases apoA-I more dramatically in the CNS compared to the periphery.	GW 3965	52-58	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	91-96	
20739291-3	2010	Agonists of liver X receptors (LXR), including GW3965, induce transcription of several genes including ABCA1 and apoE, and reduce Abeta levels and improve cognition in AD mice.	GW 3965	47-53	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	103-108	
20739291-9	2010	APP/PS1 mice treated with either 2.5 or 33 mg/kg/day of GW3965 showed a clear trend toward reduced amyloid burden in hippocampus and whole brain, whereas APP/PS1-treated mice lacking ABCA1 failed to display reduced amyloid load in the whole brain and showed trends toward increased hippocampal amyloid.	GW 3965	56-62	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	183-188	
20739291-10	2010	Treatment of APP/PS1 mice with either dose of GW3965 completely restored novel object recognition memory to wild-type levels, which required ABCA1.	GW 3965	46-52	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	141-146	
20739291-11	2010	These results suggest that ABCA1 contributes to several beneficial effects of the LXR agonist GW3965 in APP/PS1 mice.	GW 3965	94-100	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	27-32	
28028143-12	2017	In vitro, GW3965 treatment (5 muM) increased ABCA1/synaptophysin level and neurite/axonal outgrowth in primary cortical neurons derived from ABCA1fl/fl embryos, but not in neurons derived from ABCA1-B/-B embryos.	GW 3965	10-16	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	45-50	
28028143-12	2017	In vitro, GW3965 treatment (5 muM) increased ABCA1/synaptophysin level and neurite/axonal outgrowth in primary cortical neurons derived from ABCA1fl/fl embryos, but not in neurons derived from ABCA1-B/-B embryos.	GW 3965	10-16	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	141-146	
28028143-12	2017	In vitro, GW3965 treatment (5 muM) increased ABCA1/synaptophysin level and neurite/axonal outgrowth in primary cortical neurons derived from ABCA1fl/fl embryos, but not in neurons derived from ABCA1-B/-B embryos.	GW 3965	10-16	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	141-146	
28028143-14	2017	CONCLUSIONS: ABCA1/ApoE/HDL pathway, at least partially, contributes to GW3965-induced neurorestoration after stroke.	GW 3965	72-78	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	13-18	
20739291-0	2010	ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice.	GW 3965	100-106	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	0-35