PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22654799-0 2011 Sunitinib Inhibits Cell Proliferation and Alters Steroidogenesis by Down-Regulation of HSD3B2 in Adrenocortical Carcinoma Cells. Sunitinib 0-9 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 Homo sapiens 87-93 22654799-11 2011 Sunitinib induced down-regulation of HSD3B2 mRNA and protein in ACC cell lines (mRNA: 1 muM 44 +- 16%*; 5 muM 22 +- 2%*; 10 muM 19 +- 4%*; protein: 1 muM 82 +- 8%; 5 muM 63 +- 8%*; 10 muM 55 +- 9%*). Sunitinib 0-9 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 Homo sapiens 37-43 22654799-14 2011 Sunitinib exhibits anti-proliferative effects in vitro, and appears to specifically block adrenal steroidogenesis by down-regulation of HSD3B2, rendering it a promising option for treatment of ACC. Sunitinib 0-9 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 Homo sapiens 136-142