PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25460504-0 2015 Sunitinib prevents cachexia and prolongs survival of mice bearing renal cancer by restraining STAT3 and MuRF-1 activation in muscle. Sunitinib 0-9 signal transducer and activator of transcription 3 Mus musculus 94-99 33212804-0 2020 Small-Dose Sunitinib Modulates p53, Bcl-2, STAT3, and ERK1/2 Pathways and Protects against Adenine-Induced Nephrotoxicity. Sunitinib 11-20 signal transducer and activator of transcription 3 Mus musculus 43-48 33212804-10 2020 Furthermore, sunitinib decreased (p < 0.5) renal levels of TGF-beta1, p-ERK1/2, and phospho-STAT3 while elevating Bcl-2 expression score. Sunitinib 13-22 signal transducer and activator of transcription 3 Mus musculus 92-97 32511016-0 2020 Sunitinib inhibits PD-L1 expression in osteosarcoma by targeting STAT3 and remodels the immune system in tumor-bearing mice. Sunitinib 0-9 signal transducer and activator of transcription 3 Mus musculus 65-70 32511016-5 2020 Results: Sunitinib reduced the expression of PD-L1 by inhibiting the activation of STAT3 and suppressed the migration and invasion in osteosarcoma cells. Sunitinib 9-18 signal transducer and activator of transcription 3 Mus musculus 83-88 32511016-7 2020 Conclusion: Sunitinib inhibits PD-L1 expression by targeting STAT3 and remodels the immune system in tumor-bearing mice. Sunitinib 12-21 signal transducer and activator of transcription 3 Mus musculus 61-66 35157045-0 2022 Sunitinib inhibits STAT3 phosphorylation in cardiac muscle and prevents cardiomyopathy in the mdx mouse model of Duchenne muscular dystrophy. Sunitinib 0-9 signal transducer and activator of transcription 3 Mus musculus 19-24 35157045-11 2022 Our results showed sunitinib treatment reduced STAT3 phosphorylation in the heart muscle of mdx mice, improved cardiac electrical function, increased cardiac output and stroke volume, decreased ventricular hypertrophy, reduced cardiomyocytes membrane damage, fibrotic tissue deposition, and slightly decreased cardiac inflammation. Sunitinib 19-28 signal transducer and activator of transcription 3 Mus musculus 47-52 30806670-6 2019 Sunitinib exerts its regenerative effects via transient inhibition of SHP-2 and subsequent activation of the STAT3 pathway. Sunitinib 0-9 signal transducer and activator of transcription 3 Mus musculus 109-114 27770111-0 2016 Correction: Sunitinib prevents cachexia and prolongs survival of mice bearing renal cancer by restraining STAT3 and MuRF-1 activation in muscle. Sunitinib 12-21 signal transducer and activator of transcription 3 Mus musculus 106-111 25460504-9 2015 Among the mechanisms, we herein show that sunitinib is able to restrain the overactivation of STAT3 and MuRF-1 pathways, involved in enhanced muscle protein catabolism during cancer cachexia. Sunitinib 42-51 signal transducer and activator of transcription 3 Mus musculus 94-99 25068886-7 2014 Interestingly, sunitinib modulated tumor infiltration with bone marrow-derived cells (CD45+), recruitment of M2-like macrophages (CD163+) and activation of inflammatory pathways (phospho-STAT3) in a manner that was age-dependent. Sunitinib 15-24 signal transducer and activator of transcription 3 Mus musculus 187-192 19244102-0 2009 Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells. Sunitinib 0-9 signal transducer and activator of transcription 3 Mus musculus 24-29 21898502-10 2012 In addition, sunitinib treatment of tumor-bearing mice was associated with suppression of STAT3 and a block in T-cell tolerance. Sunitinib 13-22 signal transducer and activator of transcription 3 Mus musculus 90-95 21898502-11 2012 CONCLUSION: These findings indicate that sunitinib inhibits HCC tumor growth directly through the STAT3 pathway and prevents tumor antigen-specific CD8(+) T-cell tolerance, thus defining a synergistic chemoimmunotherapeutic approach for HCC. Sunitinib 41-50 signal transducer and activator of transcription 3 Mus musculus 98-103 19244102-4 2009 We show that sunitinib induces tumor cell apoptosis and growth arrest in RCC tumor cells, which correlates with signal transducer and activator of transcription 3 (Stat3) activity inhibition. Sunitinib 13-22 signal transducer and activator of transcription 3 Mus musculus 112-162 19244102-4 2009 We show that sunitinib induces tumor cell apoptosis and growth arrest in RCC tumor cells, which correlates with signal transducer and activator of transcription 3 (Stat3) activity inhibition. Sunitinib 13-22 signal transducer and activator of transcription 3 Mus musculus 164-169 19244102-6 2009 Reduction of Stat3 activity enhances the antitumor effects of sunitinib, whereas expression of a constitutively activated Stat3 mutant rescues tumor cell death. Sunitinib 62-71 signal transducer and activator of transcription 3 Mus musculus 13-18 19244102-8 2009 Sunitinib also inhibits Stat3 in Renca tumor-associated myeloid-derived suppressor cells (MDSC), down-regulates angiogenic gene expression, and reduces MDSCs and tumor T regulatory cells. Sunitinib 0-9 signal transducer and activator of transcription 3 Mus musculus 24-29 19244102-9 2009 These results suggest that Stat3 activity is important for RCC response to sunitinib, and Stat3 inhibition permits the direct proapoptotic activity of sunitinib on tumor cells and positive effects on tumor immunologic microenvironment. Sunitinib 75-84 signal transducer and activator of transcription 3 Mus musculus 27-32 19244102-9 2009 These results suggest that Stat3 activity is important for RCC response to sunitinib, and Stat3 inhibition permits the direct proapoptotic activity of sunitinib on tumor cells and positive effects on tumor immunologic microenvironment. Sunitinib 151-160 signal transducer and activator of transcription 3 Mus musculus 90-95