PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16904088-6	2006	However, the anti-apoptotic effects of EPO were significantly decreased in wild-type cardiomyocytes treated with L-NAME, which inhibits nitric oxide synthase activity.	NG-Nitroarginine Methyl Ester	113-119	erythropoietin	Mus musculus	39-42	
11849379-12	2002	The results of an in vivo mouse assay revealed that L-NAME inhibited the expression of Epo, but this inhibition of Epo expression by L-NAME was rescued by pretreatment with L-arginine.	NG-Nitroarginine Methyl Ester	52-58	erythropoietin	Mus musculus	87-90	
12490547-6	2003	Compared with their wild-type littermates, aortic rings of Epo transgenic animals exhibited a marked reduction in vascular reactivity to ET-1 and big ET-1, but this effect was abrogated upon preincubation with the NO synthase inhibitor N-nitro-L-arginine methyl ester (L-NAME).	NG-Nitroarginine Methyl Ester	269-275	erythropoietin	Mus musculus	59-62	
11849379-12	2002	The results of an in vivo mouse assay revealed that L-NAME inhibited the expression of Epo, but this inhibition of Epo expression by L-NAME was rescued by pretreatment with L-arginine.	NG-Nitroarginine Methyl Ester	133-139	erythropoietin	Mus musculus	115-118	
10961869-4	2000	L-NAME (analogue of L-NMMA) also inhibited Epo production in anemic mice.	NG-Nitroarginine Methyl Ester	0-6	erythropoietin	Mus musculus	43-46	
10678740-5	2000	Renal and hepatic EPO gene expression in wt+L-NAME appeared moderately increased relative to wt with a maximal 2.5-fold enhancement after CO exposure.	NG-Nitroarginine Methyl Ester	44-50	erythropoietin	Mus musculus	18-21	
10678740-6	2000	EPO mRNA levels in eNOS-/- mirrored those of wt+L-NAME, but the effects were less prominent.	NG-Nitroarginine Methyl Ester	48-54	erythropoietin	Mus musculus	0-3	
8397229-2	1993	Serum levels of EPO in ex-hypoxic polycythemic mice were significantly increased after injections of 200 micrograms/kg sodium nitroprusside for 4 d. One injection of NG-nitro-L-arginine methyl ester (L-NAME) produced a significant dose-related decrease in serum levels of EPO in ex-hypoxic polycythemic mice in response to hypoxia.	NG-Nitroarginine Methyl Ester	166-198	erythropoietin	Mus musculus	16-19	
8397229-2	1993	Serum levels of EPO in ex-hypoxic polycythemic mice were significantly increased after injections of 200 micrograms/kg sodium nitroprusside for 4 d. One injection of NG-nitro-L-arginine methyl ester (L-NAME) produced a significant dose-related decrease in serum levels of EPO in ex-hypoxic polycythemic mice in response to hypoxia.	NG-Nitroarginine Methyl Ester	166-198	erythropoietin	Mus musculus	272-275	
8397229-2	1993	Serum levels of EPO in ex-hypoxic polycythemic mice were significantly increased after injections of 200 micrograms/kg sodium nitroprusside for 4 d. One injection of NG-nitro-L-arginine methyl ester (L-NAME) produced a significant dose-related decrease in serum levels of EPO in ex-hypoxic polycythemic mice in response to hypoxia.	NG-Nitroarginine Methyl Ester	200-206	erythropoietin	Mus musculus	16-19	
19901910-9	2010	In contrast, coadministration of L-Name abolished EPO-mediated tissue protection by abrogating the dilatory effect resulting in reduced FCD and tissue survival, without counteracting angiogenesis and apoptotic cell death, whereas additional administration of bevacizumab did not influence the beneficial effect of EPO on flap survival despite abrogating angiogenesis.	NG-Nitroarginine Methyl Ester	33-39	erythropoietin	Mus musculus	50-53	
19901910-9	2010	In contrast, coadministration of L-Name abolished EPO-mediated tissue protection by abrogating the dilatory effect resulting in reduced FCD and tissue survival, without counteracting angiogenesis and apoptotic cell death, whereas additional administration of bevacizumab did not influence the beneficial effect of EPO on flap survival despite abrogating angiogenesis.	NG-Nitroarginine Methyl Ester	33-39	erythropoietin	Mus musculus	314-317