PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34937861-0	2021	Correlation of ACE2 with RAS components after Losartan treatment in light of COVID-19.	Losartan	46-54	angiotensin converting enzyme 2	Homo sapiens	15-19	
34631362-7	2021	Captopril, moexipril, benazepril, fosinopril, losartan, remdesivir, Sigma ACEI, NAA, and NAM interacted and docked at the interface of ACE2 and SARS-CoV-2 spike protein complex.	Losartan	46-54	angiotensin converting enzyme 2	Homo sapiens	135-139	
34529122-9	2021	Soluble ACE2 was higher in patients treated with angiotensin receptors blockers and beta-blockers, accordingly with losartan and metoprolol upregulation of ACE1 and ACE2 in HUVECs.	Losartan	116-124	angiotensin converting enzyme 2	Homo sapiens	8-12	
34529122-9	2021	Soluble ACE2 was higher in patients treated with angiotensin receptors blockers and beta-blockers, accordingly with losartan and metoprolol upregulation of ACE1 and ACE2 in HUVECs.	Losartan	116-124	angiotensin converting enzyme 2	Homo sapiens	165-169	
34646263-11	2021	The sartans (olmesartan and losartan) showed non-statistically significant ACE2 modulation in Calu-3 and endothelial cells, as compared to untreated control cells.	Losartan	28-36	angiotensin converting enzyme 2	Homo sapiens	75-79	
35359831-2	2022	However, it is unclear whether ACE1 inhibitors (e.g., lisinopril) or angiotensin receptor blockers (e.g., losartan) alter tissue ACE2 expression.	Losartan	106-114	angiotensin converting enzyme 2	Homo sapiens	129-133	
35359831-13	2022	Remarkably, the addition of losartan prevented lisinopril-induced increases in ACE2 across tissues.	Losartan	28-36	angiotensin converting enzyme 2	Homo sapiens	79-83	
33294307-10	2021	Our in silico study revealed that losartan and imatinib could probably: (1) decline SARS-CoV2 affinity to ACE2.	Losartan	34-42	angiotensin converting enzyme 2	Homo sapiens	106-110	
35106453-4	2022	Losartan, an angiotensin II receptor blocker being tested in COVID-19 patients, inhibited angiotensin II mediated internalization of ACE2, upregulated interferon stimulated genes (IFITM1 and BST2) known to restrict viral entry, and attenuated the infection of proximal tubule cells by SARS-CoV-2.	Losartan	0-8	angiotensin converting enzyme 2	Homo sapiens	133-137	
18403595-6	2008	In vitro, Ang II was able to up-regulate ACE and down-regulate ACE2 in human kidney tubular cells, which were blocked by an angiotensin II (AT)1 receptor antagonist (losartan), but not by an AT2 receptor blocker (PD123319).	Losartan	166-174	angiotensin converting enzyme 2	Homo sapiens	63-67