PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33405241-0 2021 Angiotensin II receptor blockers valsartan and losartan improve survival rate clinically and suppress tumor growth via apoptosis related to PI3K/AKT signaling in nasopharyngeal carcinoma. Losartan 47-55 AKT serine/threonine kinase 1 Homo sapiens 145-148 32186097-9 2019 Real-time PCR and western blotting analyses showed that the expression levels of PI3K, Akt, and mTOR in SHRs were significantly up-regulated by EA and Losartan (P < 0.01), while the expression levels of PTEN and ANP were down-regulated (P < 0.01). Losartan 151-159 AKT serine/threonine kinase 1 Homo sapiens 87-90 32969473-7 2020 The levels of phosphorylated phosphatidylinositol 3-kinase (p-PI3K) and phosphorylated protein kinase B (p-Akt) were increased by Ang II and then reduced by losartan in SNK-6 cells. Losartan 157-165 AKT serine/threonine kinase 1 Homo sapiens 107-110 28518223-10 2018 We also found that Losartan markedly increased endothelial NO synthase (eNOS) phosphorylation at Ser(633,1177) and dephosphorylation at Thr(495), which involved AKT and ERK. Losartan 19-27 AKT serine/threonine kinase 1 Homo sapiens 161-164 28008588-2 2017 In this study, we demonstrate that losartan administration increased phosphorylation of Akt and its downstream Akt substrate of 160 kDa (AS160), enhanced plasma membrane translocation of glucose transporter type 4 (GLUT4), and increased glucose uptake, along with increased Src phosphorylation as well as reduced expression of docking protein 1(DOK1) in palmitate-treated 3T3-L1 adipocytes. Losartan 35-43 AKT serine/threonine kinase 1 Homo sapiens 88-91 34604421-6 2021 By adding receptors antagonists (losartan, AT1R antagonist and PD 123319, AT2R antagonist) and/or signaling modulators for AMPK, Akt/PI3K, p38 and PKC we showed the protective effect was enhanced with losartan and abolished with PD 123319. Losartan 201-209 AKT serine/threonine kinase 1 Homo sapiens 129-132 28008588-5 2017 Our results suggest that anti-insulin resistance ability of losartan is mediated by Src/DOK1/Akt pathway. Losartan 60-68 AKT serine/threonine kinase 1 Homo sapiens 93-96 10692557-7 2000 For candesartan this effect was concentration-dependent, yielding a pK(B) value for losartan of 7.7, which is similar to the pK(B) from previously obtained AT concentration-response curves. Losartan 84-92 AKT serine/threonine kinase 1 Homo sapiens 68-72