PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22587908-10	2012	Additionally, losartan prevented the profibrogenic response, decreasing Ang II, TGF-beta(1) and alpha-SMA levels and normalizing AQP-2 expression in the HS-L group.	Losartan	14-22	actin gamma 2, smooth muscle	Rattus norvegicus	96-105	
30710617-8	2019	In vitro, incubation with losartan prevented Wnt/beta-catenin-mediated fibronectin, alpha-smooth muscle actin and Snail1 expression, suggesting that the fibrogenic action of Wnt/beta-catenin is dependent on RAS activation.	Losartan	26-34	actin gamma 2, smooth muscle	Rattus norvegicus	84-109	
21849800-6	2011	Immunohistochemical analyses demonstrated increased tubulointerstitial macrophage infiltration, apoptosis and increased vimentin and alpha-smooth-muscle-actin expression in animals exposed to losartan.	Losartan	192-200	actin gamma 2, smooth muscle	Rattus norvegicus	133-158	
23243430-5	2012	Sal B and losartan also inhibited Ang II-stimulated HSC activation including cell proliferation and expression of type I collagen I (Col-I) and alpha-smooth muscle actin (alpha-SMA) production in vitro, reduced the gene expression of transforming growth factor beta (TGF-beta), and downregulated AT1R expression and ERK and c-Jun phosphorylation.	Losartan	10-18	actin gamma 2, smooth muscle	Rattus norvegicus	144-169	
23243430-5	2012	Sal B and losartan also inhibited Ang II-stimulated HSC activation including cell proliferation and expression of type I collagen I (Col-I) and alpha-smooth muscle actin (alpha-SMA) production in vitro, reduced the gene expression of transforming growth factor beta (TGF-beta), and downregulated AT1R expression and ERK and c-Jun phosphorylation.	Losartan	10-18	actin gamma 2, smooth muscle	Rattus norvegicus	171-180	
17442727-9	2007	Early losartan treatment further increased alpha-smooth muscle actin and collagen in the obstructed kidney and induced apoptosis, macrophages, and collagen in the contralateral kidney.	Losartan	6-14	actin gamma 2, smooth muscle	Rattus norvegicus	43-68