PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25567153-16 2014 CONCLUSIONS: Losartan has a protective effect on LPS-induced ALI, which may be partly dependent on suppressions of Th1 and Th17 polarization response. Losartan 13-21 negative elongation factor complex member C/D, Th1l Mus musculus 115-118 22020765-0 2012 Losartan inhibits conventional dendritic cell maturation and Th1 and Th17 polarization responses: Nuovel mechanisms of preventive effects on lipopolysaccharide-induced acute lung injury. Losartan 0-8 negative elongation factor complex member C/D, Th1l Mus musculus 61-64 22020765-8 2012 In addition, polarized Th1 and Th17 responses were markedly increased in LPS-induced ALI mice at 24 and 48 h. Of note, losartan led to inhibition of respiratory cDCs maturation at 6 h and suppressed Th1 and Th17 polarization responses compared with ALI mice at 24 and 48 h. Collectively, our findings may provide a novel and, at least, partial explanation for the protective effects by which losartan inhibits lung cDCs maturation and suppresses Th1 and Th17 immune responses. Losartan 119-127 negative elongation factor complex member C/D, Th1l Mus musculus 23-26 22020765-8 2012 In addition, polarized Th1 and Th17 responses were markedly increased in LPS-induced ALI mice at 24 and 48 h. Of note, losartan led to inhibition of respiratory cDCs maturation at 6 h and suppressed Th1 and Th17 polarization responses compared with ALI mice at 24 and 48 h. Collectively, our findings may provide a novel and, at least, partial explanation for the protective effects by which losartan inhibits lung cDCs maturation and suppresses Th1 and Th17 immune responses. Losartan 119-127 negative elongation factor complex member C/D, Th1l Mus musculus 31-34 22020765-8 2012 In addition, polarized Th1 and Th17 responses were markedly increased in LPS-induced ALI mice at 24 and 48 h. Of note, losartan led to inhibition of respiratory cDCs maturation at 6 h and suppressed Th1 and Th17 polarization responses compared with ALI mice at 24 and 48 h. Collectively, our findings may provide a novel and, at least, partial explanation for the protective effects by which losartan inhibits lung cDCs maturation and suppresses Th1 and Th17 immune responses. Losartan 119-127 negative elongation factor complex member C/D, Th1l Mus musculus 31-34