PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20016382-12 2010 In addition, interaction between Hsp70 and Nox4 was determined by the coimmunoprecipitation strategy showing that membrane overexpression of Hsp70 was associated with decreased Nox4 after Losartan treatment in SHRs. Losartan 188-196 NADPH oxidase 4 Rattus norvegicus 43-47 23761196-10 2014 In conclusion, our data showing a negative regulation of Hsp70 on Nox4/p22phox demonstrates a possible mechanism in explaining the antioxidative function joined to cytoskeletal integrity modulation within the effects of losartan in VSMCs from SHR. Losartan 220-228 NADPH oxidase 4 Rattus norvegicus 66-70 20016382-12 2010 In addition, interaction between Hsp70 and Nox4 was determined by the coimmunoprecipitation strategy showing that membrane overexpression of Hsp70 was associated with decreased Nox4 after Losartan treatment in SHRs. Losartan 188-196 NADPH oxidase 4 Rattus norvegicus 177-181 19652382-4 2009 Losartan treatment also down-regulated transforming growth factor-beta1 expression and attenuated the increased expression levels of p22(phox) and Nox4. Losartan 0-8 NADPH oxidase 4 Rattus norvegicus 147-151