PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22766267-5 2012 Our results showed that losartan reduced infarct volumes and improved neurobehavioral outcomes in rats subjected to MCAO-R. Losartan pretreatment significantly suppressed an increase in inducible nitric oxide synthase (iNOS) and sustained normal levels of eNOS expression 24h after MCAO-R injury. Losartan 24-32 nitric oxide synthase 2 Rattus norvegicus 186-217 23678261-10 2013 Losartan disrupts collagen fiber formation and prevents the alteration of the tissue eNOS and iNOS levels, which prevent subsequent AF induction. Losartan 0-8 nitric oxide synthase 2 Rattus norvegicus 94-98 22766267-5 2012 Our results showed that losartan reduced infarct volumes and improved neurobehavioral outcomes in rats subjected to MCAO-R. Losartan pretreatment significantly suppressed an increase in inducible nitric oxide synthase (iNOS) and sustained normal levels of eNOS expression 24h after MCAO-R injury. Losartan 24-32 nitric oxide synthase 2 Rattus norvegicus 219-223 22766267-5 2012 Our results showed that losartan reduced infarct volumes and improved neurobehavioral outcomes in rats subjected to MCAO-R. Losartan pretreatment significantly suppressed an increase in inducible nitric oxide synthase (iNOS) and sustained normal levels of eNOS expression 24h after MCAO-R injury. Losartan 124-132 nitric oxide synthase 2 Rattus norvegicus 186-217 22766267-5 2012 Our results showed that losartan reduced infarct volumes and improved neurobehavioral outcomes in rats subjected to MCAO-R. Losartan pretreatment significantly suppressed an increase in inducible nitric oxide synthase (iNOS) and sustained normal levels of eNOS expression 24h after MCAO-R injury. Losartan 124-132 nitric oxide synthase 2 Rattus norvegicus 219-223 12164873-9 2002 Losartan therapy normalized blood pressure, prevented proteinuria and renal insufficiency, abrogated the fall in renal eNOS and iNOS protein contents, mitigated renal nitrotyrosine accumulation, and prevented the histological abnormalities found in the untreated SHR. Losartan 0-8 nitric oxide synthase 2 Rattus norvegicus 128-132 18390819-4 2008 Losartan and MPG significantly inhibited oxidative stress as determined by tissue malondialdehyde + 4-hydroxynoneal and increased expression of inducible nitric oxide synthase (iNOS) in the DS rat heart. Losartan 0-8 nitric oxide synthase 2 Rattus norvegicus 144-175 18390819-4 2008 Losartan and MPG significantly inhibited oxidative stress as determined by tissue malondialdehyde + 4-hydroxynoneal and increased expression of inducible nitric oxide synthase (iNOS) in the DS rat heart. Losartan 0-8 nitric oxide synthase 2 Rattus norvegicus 177-181 18390819-10 2008 These results suggest that losartan preserves the tolerance to I/R injury by activating eNOS despite elimination of redox-sensitive upregulation of iNOS and iNOS-dependent cardioprotection in the DS rat heart. Losartan 27-35 nitric oxide synthase 2 Rattus norvegicus 148-152 18390819-10 2008 These results suggest that losartan preserves the tolerance to I/R injury by activating eNOS despite elimination of redox-sensitive upregulation of iNOS and iNOS-dependent cardioprotection in the DS rat heart. Losartan 27-35 nitric oxide synthase 2 Rattus norvegicus 157-161 15149322-9 2004 The increased inducible NOS (iNOS) activity and expression of obstructed kidney medulla, increased neuronal NOS (nNOS), and endothelial NOS (eNOS) isoforms expression and COX-2 protein expression in obstructed kidney cortex showed down-regulation of iNOS, nNOS, and COX-2 with persistent levels of eNOS after losartan administration. Losartan 309-317 nitric oxide synthase 2 Rattus norvegicus 14-27 15149322-9 2004 The increased inducible NOS (iNOS) activity and expression of obstructed kidney medulla, increased neuronal NOS (nNOS), and endothelial NOS (eNOS) isoforms expression and COX-2 protein expression in obstructed kidney cortex showed down-regulation of iNOS, nNOS, and COX-2 with persistent levels of eNOS after losartan administration. Losartan 309-317 nitric oxide synthase 2 Rattus norvegicus 29-33 20465447-8 2010 CONCLUSIONS: Oral treatment with losartan reduces iNOS expression and reestablishes the redox status, thus ameliorating the early markers of DR in a model of diabetes and hypertension. Losartan 33-41 nitric oxide synthase 2 Rattus norvegicus 50-54 34037987-8 2021 The losartan reduced plasma creatinine and its clearance, reduced macrophages and the expression of TGF-beta and iNOS in renal tissues, and reduced plasma TBARS. Losartan 4-12 nitric oxide synthase 2 Rattus norvegicus 113-117 31187418-13 2021 SBP and losartan potassium decreased the expressions of TLR4, NF-kappaB, MCP-1, iNOS, and Arg-1. Losartan 8-16 nitric oxide synthase 2 Rattus norvegicus 80-84 28915536-11 2017 Losartan with simvastatin produced similar effects on renal tissues oxidative stress, nitrite and inflammatory markers levels and on protein expressions of eNOS, iNOS, TNF-alpha, IL-6 and IL-1beta. Losartan 0-8 nitric oxide synthase 2 Rattus norvegicus 162-166