PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23678261-10	2013	Losartan disrupts collagen fiber formation and prevents the alteration of the tissue eNOS and iNOS levels, which prevent subsequent AF induction.	Losartan	0-8	nitric oxide synthase 2	Rattus norvegicus	94-98	
22766267-5	2012	Our results showed that losartan reduced infarct volumes and improved neurobehavioral outcomes in rats subjected to MCAO-R. Losartan pretreatment significantly suppressed an increase in inducible nitric oxide synthase (iNOS) and sustained normal levels of eNOS expression 24h after MCAO-R injury.	Losartan	24-32	nitric oxide synthase 2	Rattus norvegicus	186-217	
22766267-5	2012	Our results showed that losartan reduced infarct volumes and improved neurobehavioral outcomes in rats subjected to MCAO-R. Losartan pretreatment significantly suppressed an increase in inducible nitric oxide synthase (iNOS) and sustained normal levels of eNOS expression 24h after MCAO-R injury.	Losartan	24-32	nitric oxide synthase 2	Rattus norvegicus	219-223	
22766267-5	2012	Our results showed that losartan reduced infarct volumes and improved neurobehavioral outcomes in rats subjected to MCAO-R. Losartan pretreatment significantly suppressed an increase in inducible nitric oxide synthase (iNOS) and sustained normal levels of eNOS expression 24h after MCAO-R injury.	Losartan	124-132	nitric oxide synthase 2	Rattus norvegicus	186-217	
22766267-5	2012	Our results showed that losartan reduced infarct volumes and improved neurobehavioral outcomes in rats subjected to MCAO-R. Losartan pretreatment significantly suppressed an increase in inducible nitric oxide synthase (iNOS) and sustained normal levels of eNOS expression 24h after MCAO-R injury.	Losartan	124-132	nitric oxide synthase 2	Rattus norvegicus	219-223	
15149322-9	2004	The increased inducible NOS (iNOS) activity and expression of obstructed kidney medulla, increased neuronal NOS (nNOS), and endothelial NOS (eNOS) isoforms expression and COX-2 protein expression in obstructed kidney cortex showed down-regulation of iNOS, nNOS, and COX-2 with persistent levels of eNOS after losartan administration.	Losartan	309-317	nitric oxide synthase 2	Rattus norvegicus	14-27	
15149322-9	2004	The increased inducible NOS (iNOS) activity and expression of obstructed kidney medulla, increased neuronal NOS (nNOS), and endothelial NOS (eNOS) isoforms expression and COX-2 protein expression in obstructed kidney cortex showed down-regulation of iNOS, nNOS, and COX-2 with persistent levels of eNOS after losartan administration.	Losartan	309-317	nitric oxide synthase 2	Rattus norvegicus	29-33	
31187418-13	2021	SBP and losartan potassium decreased the expressions of TLR4, NF-kappaB, MCP-1, iNOS, and Arg-1.	Losartan	8-16	nitric oxide synthase 2	Rattus norvegicus	80-84	
28915536-11	2017	Losartan with simvastatin produced similar effects on renal tissues oxidative stress, nitrite and inflammatory markers levels and on protein expressions of eNOS, iNOS, TNF-alpha, IL-6 and IL-1beta.	Losartan	0-8	nitric oxide synthase 2	Rattus norvegicus	162-166	
20465447-8	2010	CONCLUSIONS: Oral treatment with losartan reduces iNOS expression and reestablishes the redox status, thus ameliorating the early markers of DR in a model of diabetes and hypertension.	Losartan	33-41	nitric oxide synthase 2	Rattus norvegicus	50-54	
18390819-4	2008	Losartan and MPG significantly inhibited oxidative stress as determined by tissue malondialdehyde + 4-hydroxynoneal and increased expression of inducible nitric oxide synthase (iNOS) in the DS rat heart.	Losartan	0-8	nitric oxide synthase 2	Rattus norvegicus	144-175	
18390819-4	2008	Losartan and MPG significantly inhibited oxidative stress as determined by tissue malondialdehyde + 4-hydroxynoneal and increased expression of inducible nitric oxide synthase (iNOS) in the DS rat heart.	Losartan	0-8	nitric oxide synthase 2	Rattus norvegicus	177-181	
18390819-10	2008	These results suggest that losartan preserves the tolerance to I/R injury by activating eNOS despite elimination of redox-sensitive upregulation of iNOS and iNOS-dependent cardioprotection in the DS rat heart.	Losartan	27-35	nitric oxide synthase 2	Rattus norvegicus	148-152	
18390819-10	2008	These results suggest that losartan preserves the tolerance to I/R injury by activating eNOS despite elimination of redox-sensitive upregulation of iNOS and iNOS-dependent cardioprotection in the DS rat heart.	Losartan	27-35	nitric oxide synthase 2	Rattus norvegicus	157-161	
12164873-9	2002	Losartan therapy normalized blood pressure, prevented proteinuria and renal insufficiency, abrogated the fall in renal eNOS and iNOS protein contents, mitigated renal nitrotyrosine accumulation, and prevented the histological abnormalities found in the untreated SHR.	Losartan	0-8	nitric oxide synthase 2	Rattus norvegicus	128-132	
34037987-8	2021	The losartan reduced plasma creatinine and its clearance, reduced macrophages and the expression of TGF-beta and iNOS in renal tissues, and reduced plasma TBARS.	Losartan	4-12	nitric oxide synthase 2	Rattus norvegicus	113-117