PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30359991-7	2018	Mechanistically, losartan, a nonpeptide Ang II receptor antagonist, decreased Ang II-induced NLRP3 inflammasome activation, lysosomal membrane permeability, lysosomal cathepsin B release, and macrophage digestion dysfunction.	Losartan	17-25	NLR family, pyrin domain containing 3	Mus musculus	93-98	
25272939-0	2014	Losartan inhibits LPS + ATP-induced IL-1beta secretion from mouse primary macrophages by suppressing NALP3 inflammasome.	Losartan	0-8	NLR family, pyrin domain containing 3	Mus musculus	101-106	
25272939-4	2014	To further elucidate the molecular mechanism underlying the anti-IL-1beta property of losartan, we studied the LPS+ATP-induced activation of NALP3 inflammasome which controls the muturation and secretion of IL-1beta.	Losartan	86-94	NLR family, pyrin domain containing 3	Mus musculus	141-146	
25272939-8	2014	The macrophages co-cultured with losartan showed low production of IL-1beta (3907.50 +/- 143.61; P < 0.05) and low production of NALP3, caspase-1mRNA (29.82 +/- 6.92; 1.12 +/- 0.05, P < 0.05 for both).	Losartan	33-41	NLR family, pyrin domain containing 3	Mus musculus	132-137