PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11967814-11 2000 CRF rats treated with losartan manifested a significant (p<0.01) increase in the expression of nNOS-mRNA in the PH (from 84+/-1.2 to 99+/-2.6), the PVN (from 44+/-1.5 to 63+/-2.1), and the LC (from 59+/-6.7 to 76+/-2.1). Losartan 22-30 nitric oxide synthase 1 Rattus norvegicus 98-102 12052849-9 2002 Losartan also caused a significant (P<0.01) and dose-dependent rise in IL-1beta and nNOS-mRNA gene expression in the PH, PVN, and LC of phenol-injected rats. Losartan 0-8 nitric oxide synthase 1 Rattus norvegicus 87-91 11882601-3 2002 Moreover, in 2 rat models of neurogenic hypertension, one caused by intrarenal injection of phenol and the other by 5/6 nephrectomy, we observed that losartan, an Ang II type 1 receptor blocker, inhibits SNS activity and increases the abundance of IL-1beta and the neuronal isoform of nitric oxide synthase (nNOS) in the posterior hypothalamic nuclei (PH), paraventricular nuclei (PVN), and locus ceruleus (LC). Losartan 150-158 nitric oxide synthase 1 Rattus norvegicus 308-312 11882601-9 2002 Pretreatment with losartan (10 microg/kg body wt dissolved in 10 microL of aCSF) given ICV 20 minutes before Ang II abolished the effects of Ang II on BP, RSNA, and NE secretion from the PH and IL-1beta and nNOS mRNA. Losartan 18-26 nitric oxide synthase 1 Rattus norvegicus 207-211 12052849-12 2002 These studies have demonstrated that the antihypertensive action of losartan in the phenol renal injury model is largely mediated by inhibition of central and peripheral SNS activity and suggest that activation of IL-1beta and nNOS, 2 important modulators of central SNS activity, mediates the inhibitory action of losartan on SNS activity. Losartan 68-76 nitric oxide synthase 1 Rattus norvegicus 227-231 11566905-15 2001 Western blotting for nNOS in kidney cortex and medulla showed a protein increase in both fractions of 1K1C versus controls and was normalized by losartan plus tempol treatment. Losartan 145-153 nitric oxide synthase 1 Rattus norvegicus 21-25 11967814-14 2000 The studies also suggest that the inhibitory action of losartan on the SNS may be mediated by activation of IL-1beta, which, in turn, stimulates nNOS, an important modulator of central SNS activity. Losartan 55-63 nitric oxide synthase 1 Rattus norvegicus 145-149 21831995-5 2011 Angiotensin II (Ang II) type I receptor (AT(1)) antagonist losartan (Los) treatment in rats with CHF reduced renal sympathetic nerve activity with concomitant normalization of protein expression of CAPON and nNOS in the PVN. Losartan 59-67 nitric oxide synthase 1 Rattus norvegicus 208-212 10203353-5 1999 Losartan treatment was used to determine the role of angiotensin II (AngII) AT1 receptors in the inhibition of nNOS expression in 5/6 Nx. Losartan 0-8 nitric oxide synthase 1 Rattus norvegicus 111-115 10203353-6 1999 Losartan had no effect on the decreased expression of nNOS in the inner medulla, but partially increased nNOS protein expression in the cortex of 5/6 Nx rats. Losartan 0-8 nitric oxide synthase 1 Rattus norvegicus 105-109 10203353-7 1999 In contrast, in sham rats losartan significantly inhibited nNOS protein expression in the cortex (0.66+/-0.04-fold of sham values, P<0.05, n = 6) and inner medulla (0.74+/-0.12-fold of sham values, P<0.05, n = 6). Losartan 26-34 nitric oxide synthase 1 Rattus norvegicus 59-63 10203353-8 1999 nNOS mRNA was significantly decreased in cortex and inner medulla from 5/6 Nx rats, and the effects of losartan on nNOS mRNA paralleled those observed on nNOS protein expression. Losartan 103-111 nitric oxide synthase 1 Rattus norvegicus 0-4 10203353-8 1999 nNOS mRNA was significantly decreased in cortex and inner medulla from 5/6 Nx rats, and the effects of losartan on nNOS mRNA paralleled those observed on nNOS protein expression. Losartan 103-111 nitric oxide synthase 1 Rattus norvegicus 115-119 10203353-8 1999 nNOS mRNA was significantly decreased in cortex and inner medulla from 5/6 Nx rats, and the effects of losartan on nNOS mRNA paralleled those observed on nNOS protein expression. Losartan 103-111 nitric oxide synthase 1 Rattus norvegicus 115-119 28149929-11 2017 Losartan prevented ethanol-induced increase in the aortic expression of nNOS. Losartan 0-8 nitric oxide synthase 1 Rattus norvegicus 72-76 20056918-9 2010 Immunoblotting and immunohistochemical analysis further showed that inhibition of Ang II activity by losartan or tempol significantly increased the expression extracellular signal-regulated kinase (ERK)1/2, ribosomal protein S6 kinase (RSK), and also increased neuronal NO synthase (nNOS) phosphorylation. Losartan 101-109 nitric oxide synthase 1 Rattus norvegicus 283-287 19578649-6 2009 After 28 days, nNOS expression was significantly increased by 1.7-fold in the clipped kidneys of 2K1C rats and by 3-fold in the non-clipped kidneys of 2K1C rats compared with sham rats, but was normalized by losartan. Losartan 208-216 nitric oxide synthase 1 Rattus norvegicus 15-19