PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9576131-10 1998 The nonpeptide AT1 receptor blocker losartan antagonizes Ang II-induced [Ca2+]i increases in both cell groups, supporting mediation by native AT1B receptors and effective coupling of this subtype to second messenger systems leading to calcium entry and mobilization. Losartan 36-44 angiotensin II receptor, type 1b Mus musculus 142-146 23636094-6 2013 The therapeutic effects of losartan in Fbln4(SMKO) mice do not require the AngII receptor type 2 (Agtr2) but likely require both type 1a (Agtr1a) and 1b (Agtr1b) receptors. Losartan 27-35 angiotensin II receptor, type 1b Mus musculus 154-160 9576131-11 1998 Our results demonstrate that Ang II causes calcium signaling in AT1A-deficient VSMCs that is mediated by an endogenous losartan-sensitive AT1B receptor. Losartan 119-127 angiotensin II receptor, type 1b Mus musculus 138-142 9140053-5 1997 This pressor response was not blocked by pretreatment with sympatholytic agents but was completely inhibited by the AT1-receptor antagonists, losartan and candesartan, suggesting that it is directly mediated by AT1B receptors. Losartan 142-150 angiotensin II receptor, type 1b Mus musculus 211-215 9140053-6 1997 Chronic treatment of Agtr1A -/- mice with losartan reduced systolic blood pressure from 80 +/- 5 to 72 +/- 4 mmHg (P < 0.04), suggesting a role for AT1B receptors in chronic blood pressure regulation. Losartan 42-50 angiotensin II receptor, type 1b Mus musculus 151-155