PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32798558-8 2020 KEY FINDINGS: Results from humans showed that anesthesia with Dex decreased the number of both CD68 positive cells and CD86 positive cells and down-regulated level of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and monocyte chemotactic protein 1 (MCP-1) in human lung. Dexmedetomidine 62-65 C-C motif chemokine ligand 2 Homo sapiens 238-268 32798558-8 2020 KEY FINDINGS: Results from humans showed that anesthesia with Dex decreased the number of both CD68 positive cells and CD86 positive cells and down-regulated level of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and monocyte chemotactic protein 1 (MCP-1) in human lung. Dexmedetomidine 62-65 C-C motif chemokine ligand 2 Homo sapiens 270-275 28286770-0 2017 Dexmedetomidine Attenuates Lipopolysaccharide Induced MCP-1 Expression in Primary Astrocyte. Dexmedetomidine 0-15 C-C motif chemokine ligand 2 Homo sapiens 54-59 28286770-4 2017 This study aimed to investigate the potential effects of DEX on the production of MCP-1 in lipopolysaccharide-stimulated astrocytes. Dexmedetomidine 57-60 C-C motif chemokine ligand 2 Homo sapiens 82-87 28286770-10 2017 Administration of DEX significantly inhibited the expression of MCP-1 mRNA (P < 0.001). Dexmedetomidine 18-21 C-C motif chemokine ligand 2 Homo sapiens 64-69 28286770-13 2017 DEX is a potent suppressor of MCP-1 in astrocytes induced with lipopolysaccharide through alpha2A-adrenergic receptors, which potentially explains its beneficial effects in the treatment of delirium by attenuating neuroinflammation. Dexmedetomidine 0-3 C-C motif chemokine ligand 2 Homo sapiens 30-35