PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27104510-6	2016	The western blot results revealed that exposure to UA was associated with decreased expression of the anti-apoptotic proteins Mcl-1, Bcl-xL, Bcl-2, and TCTP and increased expression of apoptosis-related proteins TNF-alpha, Fas, FADD, Bax, cleaved caspase-3, caspase-8, caspase-9, and PARP.	ursolic acid	51-53	BCL2 like 1	Homo sapiens	133-139	
29956797-8	2018	The apoptosis-associated signaling showed that ursolic acid decreased the phosphorylation of AKT (Ser473) and B-cell lymphoma 2 (Bcl-2)-associated agonist of cell death (BAD; Ser136), and the protein levels of Bcl-2 and Bcl-extra large (Bcl-xL), and increased the expression of BAD and Bcl-2-associated X (Bax) protein in CAR cells.	ursolic acid	47-59	BCL2 like 1	Homo sapiens	237-243	
28714512-8	2017	UA decreased the expression of downstream target genes of STAT3, such as Bcl-2, Bcl-xl and survivin in general, with difference in these cell lines.	ursolic acid	0-2	BCL2 like 1	Homo sapiens	80-86	
17855663-9	2007	Ursolic acid down-regulated the expression of STAT3-regulated gene products such as cyclin D1, Bcl-2, Bcl-xL, survivin, Mcl-1, and vascular endothelial growth factor.	ursolic acid	0-12	BCL2 like 1	Homo sapiens	102-108	
24399733-7	2013	Consistently, western blotting revealed that ursolic acid effectively cleaved poly (ADP-ribose) polymerase (PARP), activated caspase-9 and -3, suppressed the expression of survival proteins such as Bcl-XL, Bcl-2 and Mcl-1, and upregulated the expression of Bax in PC-3 cells.	ursolic acid	45-57	BCL2 like 1	Homo sapiens	198-204	
21826595-5	2011	After SW480 cells were treated by UA at the concentrations of 0-40 mumol/L for 48 h, FCM showed that annexin V (AV) positive cells and hypodiploid peak ratio increased along with the increase in the drug"s concentrations; and Western blot found that expressions of Bcl-2, Bcl-xL and survivin decreased in a concentration-dependent manner.	ursolic acid	34-36	BCL2 like 1	Homo sapiens	272-278	
26503559-5	2015	The induction of apoptosis by UA was associated with a decrease in the levels of Bcl-2, Bcl-xl, survivin, and activated caspase-3.	ursolic acid	30-32	BCL2 like 1	Homo sapiens	88-94	
24881958-3	2014	Here, we reported that UA induced apoptosis through the mitochondrial intrinsic pathway in HeLa cells, as shown by release of cytosol cytochrome c, activation of caspase-9 and -3, reduction of Bcl-2 and Bcl-xL, and increase of Bax and Bak.	ursolic acid	23-25	BCL2 like 1	Homo sapiens	203-209	
22791147-7	2012	Consistently, Western blotting revealed that ursolic acid effectively cleaved poly(ADP-ribose) polymerase (PARP), caspase-9 and -3, suppressed the expression of survival genes such as c-Myc, Bcl-x(L) and astrocyte elevated gene (AEG)-1, and upregulated phosphorylation of extracellular signal-regulated kinase (ERK) in SK-OV-3 cells.	ursolic acid	45-57	BCL2 like 1	Homo sapiens	191-199	
17764066-3	2007	Here, we report that treatment with UA induces apoptosis in human leukemia K562 cells and down-regulates protein levels of bcl-xL.	ursolic acid	36-38	BCL2 like 1	Homo sapiens	123-129	
16309197-5	2005	Western blot analysis indicated that the induction of apoptosis by GA and ursolic acid was accompanied with an activation of caspase-8 and a reduction in the anti-apoptotic proteins, Bcl-2 and Bcl-xL, although the pro-apoptotic proteins, Bax and Bak, remained unaffected.	ursolic acid	74-86	BCL2 like 1	Homo sapiens	193-199