PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15320779-7 2004 Recent data showed that in rats with left ventricular dysfunction after extensive myocardial infarction, eplerenone on top of ACE inhibition more effectively improved cardiac remodeling and molecular alterations than ACE inhibition alone. Eplerenone 105-115 angiotensin I converting enzyme Rattus norvegicus 217-220 17903697-8 2007 Eplerenone or candesartan partially improved heart/body weight and cardiac fibrosis, improved EDR and decreased cardiac ACE and angiotensinogen mRNA levels in DS rats. Eplerenone 0-10 angiotensin I converting enzyme Rattus norvegicus 120-123 18654024-7 2008 Eplerenone, a mineralocorticoid receptor antagonist, completely blocked the increase in ACE mRNA levels and the reduction in ACE2 mRNA levels due to aldosterone. Eplerenone 0-10 angiotensin I converting enzyme Rattus norvegicus 88-91 14607457-7 2003 The addition of eplerenone to ACE inhibition prevented sarcoplasmic-reticulum calcium ATPase downregulation and the increases in LV gene expression of beta-MHC and atrial natriuretic factor more effectively than either monotherapy. Eplerenone 16-26 angiotensin I converting enzyme Rattus norvegicus 30-33