PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33629924-7	2021	Eplerenone is metabolized by the hepatic P450 cytochrome isoenzyme CYP3A4; therefore, concomitant administration with CYP3A4 inhibitors, like ritonavir, may increase plasma levels of eplerenone and, therefore, the risk of side effects, mainly hyperkalaemia.	Eplerenone	0-10	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	67-73	
33629924-7	2021	Eplerenone is metabolized by the hepatic P450 cytochrome isoenzyme CYP3A4; therefore, concomitant administration with CYP3A4 inhibitors, like ritonavir, may increase plasma levels of eplerenone and, therefore, the risk of side effects, mainly hyperkalaemia.	Eplerenone	0-10	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	118-124	
33629924-7	2021	Eplerenone is metabolized by the hepatic P450 cytochrome isoenzyme CYP3A4; therefore, concomitant administration with CYP3A4 inhibitors, like ritonavir, may increase plasma levels of eplerenone and, therefore, the risk of side effects, mainly hyperkalaemia.	Eplerenone	183-193	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	67-73	
33629924-7	2021	Eplerenone is metabolized by the hepatic P450 cytochrome isoenzyme CYP3A4; therefore, concomitant administration with CYP3A4 inhibitors, like ritonavir, may increase plasma levels of eplerenone and, therefore, the risk of side effects, mainly hyperkalaemia.	Eplerenone	183-193	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	118-124	
14503934-11	2003	Eplerenone is metabolized by CYP3A4 and administration with potent inhibitors of this enzyme is contraindicated because of the risk of hyperkalemia.	Eplerenone	0-10	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	29-35	
31408697-0	2019	The relative role of CYP3A4 and CYP3A5 in eplerenone metabolism.	Eplerenone	42-52	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	21-27	
31408697-5	2019	Eplerenone, an aldosterone antagonist, is also metabolized by CYP3A enzymes, and it has the potential to be an excellent substrate probe for CYP3A4/5.	Eplerenone	0-10	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	62-67	
31408697-5	2019	Eplerenone, an aldosterone antagonist, is also metabolized by CYP3A enzymes, and it has the potential to be an excellent substrate probe for CYP3A4/5.	Eplerenone	0-10	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	141-147	
31408697-6	2019	Eplerenone"s primary metabolite, 6 beta-hydroxyeplerenone is formed preferentially via CYP3A4, however, the relative contribution of CYP3A5 to the 21-hydroxyeplerenone metabolite formation is unknown.	Eplerenone	0-10	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	87-93	
31408697-9	2019	Based on these findings, eplerenone has the potential to serve as an in-vivo substrate probe for CYP3A4 by monitoring 6-beta-hydroxy metabolite formation as well as CYP3A4/5 by monitoring 21-hydroxy metabolite formation.	Eplerenone	25-35	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	97-103	
12433801-0	2002	Involvement of CYP3A in the metabolism of eplerenone in humans and dogs: differential metabolism by CYP3A4 and CYP3A5.	Eplerenone	42-52	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	15-20	
12433801-12	2002	Also, it is unlikely that EP would substantially inhibit the metabolism of other drugs that are metabolized by CYP3A4 or other p450 isoforms.	Eplerenone	26-28	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	111-117