PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16087786-10	2005	Aldosterone-induced ERK1/2 phosphorylation was markedly attenuated by pretreatment with eplerenone (10 micromol/L), a selective MR antagonist, or PD98059 (10 micromol/L), a specific inhibitor of MAPK kinase/ERK kinase, which is the upstream activator of ERK1/2.	Eplerenone	88-98	mitogen activated protein kinase 3	Rattus norvegicus	20-26	
16087786-10	2005	Aldosterone-induced ERK1/2 phosphorylation was markedly attenuated by pretreatment with eplerenone (10 micromol/L), a selective MR antagonist, or PD98059 (10 micromol/L), a specific inhibitor of MAPK kinase/ERK kinase, which is the upstream activator of ERK1/2.	Eplerenone	88-98	mitogen activated protein kinase 3	Rattus norvegicus	195-199	
16087786-10	2005	Aldosterone-induced ERK1/2 phosphorylation was markedly attenuated by pretreatment with eplerenone (10 micromol/L), a selective MR antagonist, or PD98059 (10 micromol/L), a specific inhibitor of MAPK kinase/ERK kinase, which is the upstream activator of ERK1/2.	Eplerenone	88-98	mitogen activated protein kinase 3	Rattus norvegicus	20-23	
16087786-10	2005	Aldosterone-induced ERK1/2 phosphorylation was markedly attenuated by pretreatment with eplerenone (10 micromol/L), a selective MR antagonist, or PD98059 (10 micromol/L), a specific inhibitor of MAPK kinase/ERK kinase, which is the upstream activator of ERK1/2.	Eplerenone	88-98	mitogen activated protein kinase 3	Rattus norvegicus	254-260	
28966243-7	2017	The phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2), 11beta-HSD1 levels, and mRNA/protein levels of collagen-I increased upon exposure to isoproterenol, but these increases were inhibited by eplerenone co-treatment.	Eplerenone	213-223	mitogen activated protein kinase 3	Rattus norvegicus	23-64	
15699469-2	2005	We also observed that the aldosterone-induced mesangial injury and ERK1/2 activation were prevented by treatment with a selective mineralocorticoid receptor (MR) antagonist, eplerenone, suggesting that the glomerular mesangium is a potential target for injuries induced by aldosterone via activation of MR.	Eplerenone	174-184	mitogen activated protein kinase 3	Rattus norvegicus	67-73	
15699469-9	2005	Pretreatment with eplerenone (10 micromol/L) significantly attenuated aldosterone-induced ERK1/2 phosphorylation.	Eplerenone	18-28	mitogen activated protein kinase 3	Rattus norvegicus	90-96	
14769808-9	2004	Furthermore, eplerenone and tempol treatments normalized the activities of ERK1/2, JNK, and BMK1.	Eplerenone	13-23	mitogen activated protein kinase 3	Rattus norvegicus	75-81	
28966243-8	2017	In primary CFs, isoproterenol increased the phosphorylation of ERK1/2 and the expression levels of both 11beta-HSD1 and collagen-I; these isoproterenol-attributable effects were inhibited by co-treatment with eplerenone and PD98059, a specific inhibitor of mitogen-activated protein kinase/ERK kinase activity.	Eplerenone	209-219	mitogen activated protein kinase 3	Rattus norvegicus	63-69	
28966243-8	2017	In primary CFs, isoproterenol increased the phosphorylation of ERK1/2 and the expression levels of both 11beta-HSD1 and collagen-I; these isoproterenol-attributable effects were inhibited by co-treatment with eplerenone and PD98059, a specific inhibitor of mitogen-activated protein kinase/ERK kinase activity.	Eplerenone	209-219	mitogen activated protein kinase 3	Rattus norvegicus	63-66	
28966243-10	2017	Eplerenone inhibited isoproterenol-induced ERK1/2 phosphorylation and expression of 11beta-HSD1 and collagen-I in primary CFs, as well as the progression of cardiac fibrosis in the left ventricle.	Eplerenone	0-10	mitogen activated protein kinase 3	Rattus norvegicus	43-49	
25488178-7	2015	Spironolactone and eplerenone increased the levels of Ca(2+), cGMP and activity of ERK 1/2, and reversed the action of aldosterone on the activity of PKC and ERK1/2.	Eplerenone	19-29	mitogen activated protein kinase 3	Rattus norvegicus	83-90	
25488178-7	2015	Spironolactone and eplerenone increased the levels of Ca(2+), cGMP and activity of ERK 1/2, and reversed the action of aldosterone on the activity of PKC and ERK1/2.	Eplerenone	19-29	mitogen activated protein kinase 3	Rattus norvegicus	158-164	
22174146-8	2011	We found that aldosterone increased phosphorylation of the redox-sensitive kinases ERK1/2-p90RSK and the NHE-1, effects that were eliminated by eplerenone or by preventing epidermal growth factor receptor transactivation.	Eplerenone	144-154	mitogen activated protein kinase 3	Rattus norvegicus	83-89