PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30358904-6	2019	RESULTS: The patient was positive for CaSR antibodies of the IgG1 subtype, which stimulated phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and inositol phosphate (IP) accumulation.	Inositol Phosphates	171-189	calcium sensing receptor	Homo sapiens	38-42	
30358904-6	2019	RESULTS: The patient was positive for CaSR antibodies of the IgG1 subtype, which stimulated phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and inositol phosphate (IP) accumulation.	Inositol Phosphates	191-193	calcium sensing receptor	Homo sapiens	38-42	
19837919-6	2009	These antibodies were detected by their ability to increase both Ca(2+)-dependent extracellular signal-regulated kinase phosphorylation and inositol phosphate accumulation in human embryonic kidney 293 cells expressing the CaSR.	Inositol Phosphates	140-158	calcium sensing receptor	Homo sapiens	223-227	
21566075-10	2011	In contrast to those transfected with WT CASR, which showed a five- to eightfold increase in total IPs at high levels of calcium, COS-7 cells transfected with the (p.T550I) mutant showed no increase confirming to the inactivating nature of the mutation.	Inositol Phosphates	99-102	calcium sensing receptor	Homo sapiens	41-45	
30381479-7	2018	Only autoantibodies recognizing CaSR epitopes 114-126 and 171-195 affected receptor activity; inositol-phosphate accumulation was increased significantly in HEK293-CaSR cells, and PTH secretion from PTH-C1 cells was reduced significantly when either were incubated with purified Ab and Ca2+ compared with Ca2+ alone.	Inositol Phosphates	94-112	calcium sensing receptor	Homo sapiens	32-36	
30381479-7	2018	Only autoantibodies recognizing CaSR epitopes 114-126 and 171-195 affected receptor activity; inositol-phosphate accumulation was increased significantly in HEK293-CaSR cells, and PTH secretion from PTH-C1 cells was reduced significantly when either were incubated with purified Ab and Ca2+ compared with Ca2+ alone.	Inositol Phosphates	94-112	calcium sensing receptor	Homo sapiens	164-168	
11102444-4	2001	In parallel, the two major signaling pathways responsible for CaSR-triggered block of PTH secretion, the generation of inositol phosphates, and the inhibition of cAMP were enhanced.	Inositol Phosphates	119-138	calcium sensing receptor	Homo sapiens	62-66	
17372216-5	2007	Paradoxically, we find that this autoantibody potentiates the Ca(2+)/Gq-dependent accumulation of inositol phosphates by slightly shifting the dose dependence curve of the Ca(2+) mediated activation of phosphatidylinositol turnover to the left, whereas it inhibits the Ca(2+)/Gi-dependent phosphorylation of ERK1/2 in HEK293 cells stably expressing human CaSR.	Inositol Phosphates	98-117	calcium sensing receptor	Homo sapiens	355-359	
14764760-6	2004	These anti-CaR antibodies activated the receptor based on their ability to increase inositol phosphate accumulation, activate MAPK, and inhibit PTH secretion.	Inositol Phosphates	84-102	calcium sensing receptor	Homo sapiens	11-14	
9722568-4	1998	The in frame deletion of 231 nucleotides of exon 5 resulted in the loss of function of the CaR as measured by calcium-stimulated production of inositol phosphates when transfected into HEK293 cells or keratinocytes.	Inositol Phosphates	143-162	calcium sensing receptor	Homo sapiens	91-94	
9722568-7	1998	The full-length CaR was expressed in undifferentiated keratinocytes consistent with their greater response to elevated extracellular calcium in terms of increased intracellular free calcium and production of inositol phosphates.	Inositol Phosphates	208-227	calcium sensing receptor	Homo sapiens	16-19