PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3277859-0 1988 Inhibition of the amplified bombesin-stimulated inositol phosphate response in N-ras transformed cells by high density culturing. Inositol Phosphates 48-66 gastrin releasing peptide Homo sapiens 28-36 2550492-2 1989 While all three SCLC lines expressed messenger RNA encoding pro-gastrin releasing peptide (GRP), only the NCI-H345 cells expressed detectable membrane receptors for GRP and responded to nanomolar concentrations of bombesin as shown by 125I-GRP binding, total inositol phosphate accumulation, and increased clonal growth in soft agarose. Inositol Phosphates 259-277 gastrin releasing peptide Homo sapiens 214-222 2669738-1 1989 Bombesin stimulation of T15 cells in which the inducible N-ras oncogene is overexpressed caused elevated production of inositol phosphates compared to uninduced cells [Wakelam, Davies, Houslay, McKay, Marshall & Hall (1986) Nature (London) 323, 173-176]. Inositol Phosphates 119-138 gastrin releasing peptide Homo sapiens 0-8 3277859-1 1988 The bombesin-stimulated inositol phosphate response is only increased in cells transformed by the overexpression of N-ras when they are cultured under sub-confluent conditions. Inositol Phosphates 24-42 gastrin releasing peptide Homo sapiens 4-12 3018591-0 1986 Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production. Inositol Phosphates 70-88 gastrin releasing peptide Homo sapiens 24-32 8306345-7 1994 Consistent with the presence of high affinity receptors, bombesin increased the formation of inositol phosphates in HuTu-80 cells in a dose-dependent manner (concentration eliciting half-maximal effect, 290 +/- 70 pM). Inositol Phosphates 93-112 gastrin releasing peptide Homo sapiens 57-65 9325344-5 1997 [D-Phe6,beta-Ala11,Phe13, Nle14]Bn-(6-14) (where Nle represents norleucine) was discovered to have high potency for stimulating inositol phosphate formation in both cell lines. Inositol Phosphates 128-146 gastrin releasing peptide Homo sapiens 32-34 1336112-10 1992 Inositol phosphates were increased in a dose-dependent fashion, with similar half-maximal values being obtained for NMB in both cell types (transfected, 1.01 +/- 0.09 nM; C6, 2.09 +/- 0.15 nM) and for the GRP analogue (transfected, 1855 +/- 140 nM; C6, 2129 +/- 250 nM). Inositol Phosphates 0-19 gastrin releasing peptide Homo sapiens 205-208 1744575-0 1991 Bombesin and bradykinin increase inositol phosphates and cytosolic free Ca2+, and stimulate DNA synthesis in human endometrial stromal cells. Inositol Phosphates 33-52 gastrin releasing peptide Homo sapiens 0-8 1321770-3 1992 Phosphoinositide hydrolysis in MCF-7 cells was stimulated by bombesin (BN) as evidenced by increases in both inositol phosphate production and cytidine diphosphate diacylglycerol (CDP-DG) accumulation. Inositol Phosphates 109-127 gastrin releasing peptide Homo sapiens 61-69 1321770-3 1992 Phosphoinositide hydrolysis in MCF-7 cells was stimulated by bombesin (BN) as evidenced by increases in both inositol phosphate production and cytidine diphosphate diacylglycerol (CDP-DG) accumulation. Inositol Phosphates 109-127 gastrin releasing peptide Homo sapiens 71-73 1744575-2 1991 In human endometrial stromal cells, bombesin and bradykinin provoked an increase in intracellular free Ca2+ and in labelled inositol phosphates when pre-incubated with [3H]myoinositol. Inositol Phosphates 124-143 gastrin releasing peptide Homo sapiens 36-44 2167151-1 1990 In [3H]inositol-labeled membranes prepared from Swiss mouse 3T3 and human small cell lung carcinoma cells, [Tyr4]-bombesin stimulated production of water-soluble inositol phosphates. Inositol Phosphates 162-181 gastrin releasing peptide Homo sapiens 114-122 1707628-2 1991 Both members of the BN family of peptides, i.e. BN and gastrin-releasing peptide (GRP), stimulated a dose-related increase in total inositol phosphate production, with a similar half-maximal effective dose (ED50) around 1 nM. Inositol Phosphates 132-150 gastrin releasing peptide Homo sapiens 20-22 1707628-2 1991 Both members of the BN family of peptides, i.e. BN and gastrin-releasing peptide (GRP), stimulated a dose-related increase in total inositol phosphate production, with a similar half-maximal effective dose (ED50) around 1 nM. Inositol Phosphates 132-150 gastrin releasing peptide Homo sapiens 48-50 1707628-2 1991 Both members of the BN family of peptides, i.e. BN and gastrin-releasing peptide (GRP), stimulated a dose-related increase in total inositol phosphate production, with a similar half-maximal effective dose (ED50) around 1 nM. Inositol Phosphates 132-150 gastrin releasing peptide Homo sapiens 55-80 1707628-2 1991 Both members of the BN family of peptides, i.e. BN and gastrin-releasing peptide (GRP), stimulated a dose-related increase in total inositol phosphate production, with a similar half-maximal effective dose (ED50) around 1 nM. Inositol Phosphates 132-150 gastrin releasing peptide Homo sapiens 82-85 2153048-4 1990 Bombesin stimulated a dose-dependent increase in the hydrolysis product inositol monophosphate during 1 h with a half-maximal effect around 1 nM. Inositol Phosphates 72-94 gastrin releasing peptide Homo sapiens 0-8 2153048-7 1990 Both bombesin- and gastrin-releasing peptide also stimulated a dose-related increase in inositol phosphate production in T47D cells, a different human breast cancer cell line. Inositol Phosphates 88-106 gastrin releasing peptide Homo sapiens 5-13 2153048-7 1990 Both bombesin- and gastrin-releasing peptide also stimulated a dose-related increase in inositol phosphate production in T47D cells, a different human breast cancer cell line. Inositol Phosphates 88-106 gastrin releasing peptide Homo sapiens 19-44