PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3124813-0 1987 Formation of inositol phosphate isomers in GH3 pituitary tumour cells stimulated with thyrotropin-releasing hormone. Inositol Phosphates 13-31 thyrotropin releasing hormone Rattus norvegicus 86-115 3131167-2 1988 The dose-response relationship for the TRH-stimulated phospholipase C was elucidated as was the relationship between the various inositol phosphates formed during the first few seconds after stimulation. Inositol Phosphates 129-148 thyrotropin releasing hormone Rattus norvegicus 39-42 3124813-6 1987 Two major inositol monophosphate (InsP) isomers were identified, namely Ins1P and Ins4P, both of which accumulate after stimulation with the hypothalamic releasing factor (TRH) (thyrotropin-releasing hormone). Inositol Phosphates 10-32 thyrotropin releasing hormone Rattus norvegicus 141-176 3124813-6 1987 Two major inositol monophosphate (InsP) isomers were identified, namely Ins1P and Ins4P, both of which accumulate after stimulation with the hypothalamic releasing factor (TRH) (thyrotropin-releasing hormone). Inositol Phosphates 10-32 thyrotropin releasing hormone Rattus norvegicus 178-207 3032661-2 1987 After protein kinase C was identified in GH3 cells by direct labeling with [3H]phorbol dibutyrate (PDB), the response to phorbol ester and TRH pretreatment on subsequent TRH-stimulated inositol phosphate (IP) accumulation was found to be inhibitory. Inositol Phosphates 205-207 thyrotropin releasing hormone Rattus norvegicus 170-173 3032661-2 1987 After protein kinase C was identified in GH3 cells by direct labeling with [3H]phorbol dibutyrate (PDB), the response to phorbol ester and TRH pretreatment on subsequent TRH-stimulated inositol phosphate (IP) accumulation was found to be inhibitory. Inositol Phosphates 185-203 thyrotropin releasing hormone Rattus norvegicus 139-142 3032661-2 1987 After protein kinase C was identified in GH3 cells by direct labeling with [3H]phorbol dibutyrate (PDB), the response to phorbol ester and TRH pretreatment on subsequent TRH-stimulated inositol phosphate (IP) accumulation was found to be inhibitory. Inositol Phosphates 185-203 thyrotropin releasing hormone Rattus norvegicus 170-173 3111461-4 1987 We have shown previously that the rise in [Ca2+]i induced by TRH occurs within about 400 ms; thus, it was important to investigate the subsecond time-course of changes in inositol phosphates caused by TRH. Inositol Phosphates 171-190 thyrotropin releasing hormone Rattus norvegicus 61-64 3111461-4 1987 We have shown previously that the rise in [Ca2+]i induced by TRH occurs within about 400 ms; thus, it was important to investigate the subsecond time-course of changes in inositol phosphates caused by TRH. Inositol Phosphates 171-190 thyrotropin releasing hormone Rattus norvegicus 201-204 3020141-1 1986 The hydrolysis of membrane phosphatidylinositol to yield [3H]labelled inositol phosphates by anterior pituitary cells was stimulated significantly by angiotensin II, TRH and neurotensin over a broad range of concentrations. Inositol Phosphates 70-89 thyrotropin releasing hormone Rattus norvegicus 166-169 3026309-4 1986 TRH stimulation of inositol phosphate formation was insensitive to pertussis toxin. Inositol Phosphates 19-37 thyrotropin releasing hormone Rattus norvegicus 0-3 3007496-3 1986 We have examined the temporal relationships between TRH-enhanced formation of inositol phosphates and TRH-elevated [Ca2+]i. Inositol Phosphates 78-97 thyrotropin releasing hormone Rattus norvegicus 52-55 6421341-0 1983 Thyrotropin-releasing hormone stimulates inositol phosphate production in normal anterior pituitary cells and GH3 tumour cells in the presence of lithium. Inositol Phosphates 41-59 thyrotropin releasing hormone Rattus norvegicus 0-29 6323219-2 1984 From the analysis of inositol phosphates in the presence of Li+ which inhibits their dephosphorylation, it can be concluded that the hydrolysis of phosphatidylinositol 4,5-biphosphate, and possibly of phosphatidylinositol 4-phosphate by phospholipase C is markedly accelerated by TRH. Inositol Phosphates 21-40 thyrotropin releasing hormone Rattus norvegicus 280-283 6421341-4 1983 Furthermore, in normal male anterior pituitary cells the dose-response profile for TRH stimulation of inositol phosphate accumulation was found to correlate well with the dose-response profile for TRH stimulation of prolactin secretion. Inositol Phosphates 102-120 thyrotropin releasing hormone Rattus norvegicus 83-86 6421341-4 1983 Furthermore, in normal male anterior pituitary cells the dose-response profile for TRH stimulation of inositol phosphate accumulation was found to correlate well with the dose-response profile for TRH stimulation of prolactin secretion. Inositol Phosphates 102-120 thyrotropin releasing hormone Rattus norvegicus 197-200 12534362-0 2003 Nitric oxide decreases the production of inositol phosphates stimulated by angiotensin II and thyrotropin-releasing hormone in anterior pituitary cells. Inositol Phosphates 41-60 thyrotropin releasing hormone Rattus norvegicus 94-123 17329249-3 2007 beta-Arrestin 2 reduced thyrotropin-releasing hormone (TRH)-stimulated inositol phosphate production and accelerated internalization of the wild type receptor but not receptor mutants where the critical phosphosites were mutated to Ala. Inositol Phosphates 71-89 thyrotropin releasing hormone Rattus norvegicus 24-53 17329249-3 2007 beta-Arrestin 2 reduced thyrotropin-releasing hormone (TRH)-stimulated inositol phosphate production and accelerated internalization of the wild type receptor but not receptor mutants where the critical phosphosites were mutated to Ala. Inositol Phosphates 71-89 thyrotropin releasing hormone Rattus norvegicus 55-58 7965720-7 1994 Tamoxifen caused the inhibition of inositol phosphate accumulation, which was stimulated in whole GH4C1 cells in culture by either thyrotropin-releasing hormone or bombesin. Inositol Phosphates 35-53 thyrotropin releasing hormone Rattus norvegicus 131-160 10087453-3 1999 Thyrotropin-releasing hormone (TRH, 100 nM) stimulated accumulation of inositol phosphates (IPs) fivefold in D5GH4C1 cells. Inositol Phosphates 71-90 thyrotropin releasing hormone Rattus norvegicus 0-29 10087453-3 1999 Thyrotropin-releasing hormone (TRH, 100 nM) stimulated accumulation of inositol phosphates (IPs) fivefold in D5GH4C1 cells. Inositol Phosphates 92-95 thyrotropin releasing hormone Rattus norvegicus 0-29 7646458-5 1995 In the presence of TRH, both receptor subtypes were able to cause stimulation of inositol phosphate generation in a pertussis-toxin-insensitive manner with similar EC50 values and to stimulate the mobilization of intracellular Ca2+, but, despite reports that TRH receptors can also interact with the G-proteins Gs and Gi2, neither receptor splice variant was able to modulate adenylate cyclase activity in either a positive or a negative manner. Inositol Phosphates 81-99 thyrotropin releasing hormone Rattus norvegicus 19-22 8051077-3 1994 Activation of this receptor with TRH caused a large stimulation in production of inositol phosphates but did not produce either activation of basal or inhibition of forskolin-amplified adenylyl cyclase activity. Inositol Phosphates 81-100 thyrotropin releasing hormone Rattus norvegicus 33-36 7964269-7 1994 Both TRH and pGlu-Glu-ProNH2 appeared to act through the same intracellular signalling mechanism, causing significant increases in intracellular inositol phosphate within the expected concentration ranges. Inositol Phosphates 145-163 thyrotropin releasing hormone Rattus norvegicus 5-8 1738433-0 1992 Thyroid hormones regulate the formation of inositol phosphate in response to thyrotropin-releasing hormone in rat anterior pituitaries. Inositol Phosphates 43-61 thyrotropin releasing hormone Rattus norvegicus 77-106 8171043-14 1994 TRH (100 nM) maximally stimulated total inositol phosphate (IP) accumulation to values approximately three times greater than controls in GH4C1 and GH4ZR7 cells only. Inositol Phosphates 40-58 thyrotropin releasing hormone Rattus norvegicus 0-3 8171043-14 1994 TRH (100 nM) maximally stimulated total inositol phosphate (IP) accumulation to values approximately three times greater than controls in GH4C1 and GH4ZR7 cells only. Inositol Phosphates 60-62 thyrotropin releasing hormone Rattus norvegicus 0-3 8349024-0 1993 Calcitriol attenuates the thyrotropin-releasing hormone-stimulated inositol phosphate production in clonal rat pituitary (GH4C1) cells. Inositol Phosphates 67-85 thyrotropin releasing hormone Rattus norvegicus 26-55 8349024-7 1993 Thus, calcitriol specifically attenuates both the basal and TRH-stimulated inositol phosphate production in GH4C1 cells. Inositol Phosphates 75-93 thyrotropin releasing hormone Rattus norvegicus 60-63 19215426-4 1990 Purified cells, obtained from the three tissues, were incubated for 30 min in media with drugs (thyrotropin-releasing hormone or angiotensin II) stimulating inositol phosphates and prolactin release, in the presence or the absence of dopamine. Inositol Phosphates 157-176 thyrotropin releasing hormone Rattus norvegicus 96-125 1657582-3 1991 Here we show that TRH stimulation of phosphoinositide (PPI) hydrolysis, measured as inositol phosphate accumulation in the presence of LiCl, desensitizes in rat pituitary GH3 cells and in rat glioma C6 cells stably transfected with mouse pituitary TRH receptor complementary DNA. Inositol Phosphates 84-102 thyrotropin releasing hormone Rattus norvegicus 18-21 19215426-6 1990 Thyrotropin-releasing hormone and angiotensin II stimulated inositol phosphates by adenomatous and 7315a cells. Inositol Phosphates 60-79 thyrotropin releasing hormone Rattus norvegicus 0-29 1651844-6 1991 EGF significantly blunted the ability of TRH to stimulate release of inositol phosphates from metabolically labeled cells. Inositol Phosphates 69-88 thyrotropin releasing hormone Rattus norvegicus 41-44 1651844-7 1991 TRH increased inositol monophosphate accumulation 6.3-fold in control cultures and 2.0-fold in EGF-treated cells. Inositol Phosphates 14-36 thyrotropin releasing hormone Rattus norvegicus 0-3 1714395-0 1991 Ca2+ channel agonists enhance thyrotropin-releasing hormone-induced inositol phosphates and prolactin secretion. Inositol Phosphates 68-87 thyrotropin releasing hormone Rattus norvegicus 30-59 2542454-0 1989 Regional dissociation of cyclic AMP and inositol phosphate formation in response to thyrotropin-releasing hormone in the rat brain. Inositol Phosphates 40-58 thyrotropin releasing hormone Rattus norvegicus 84-113 2542454-1 1989 The present study was undertaken to define effects of thyrotropin-releasing hormone (TRH) on formation of cyclic AMP (cAMP) and inositol phosphates (IPs) in rat brain regions. Inositol Phosphates 128-147 thyrotropin releasing hormone Rattus norvegicus 54-83 2542454-1 1989 The present study was undertaken to define effects of thyrotropin-releasing hormone (TRH) on formation of cyclic AMP (cAMP) and inositol phosphates (IPs) in rat brain regions. Inositol Phosphates 128-147 thyrotropin releasing hormone Rattus norvegicus 85-88 2542454-1 1989 The present study was undertaken to define effects of thyrotropin-releasing hormone (TRH) on formation of cyclic AMP (cAMP) and inositol phosphates (IPs) in rat brain regions. Inositol Phosphates 149-152 thyrotropin releasing hormone Rattus norvegicus 54-83 2542454-1 1989 The present study was undertaken to define effects of thyrotropin-releasing hormone (TRH) on formation of cyclic AMP (cAMP) and inositol phosphates (IPs) in rat brain regions. Inositol Phosphates 149-152 thyrotropin releasing hormone Rattus norvegicus 85-88 2542454-5 1989 TRH stimulated formation of IPs in the cerebellum, where the tripeptide did not change the cAMP level. Inositol Phosphates 28-31 thyrotropin releasing hormone Rattus norvegicus 0-3 2105370-2 1990 TRH caused a time- and dose-dependent accumulation of inositol phosphates in rat anterior pituitary slices. Inositol Phosphates 54-73 thyrotropin releasing hormone Rattus norvegicus 0-3 2105370-3 1990 Pretreatment with 550 nmol TRH/l completely abolished the subsequent accumulation of inositol phosphates in response to 140 nmol TRH/l. Inositol Phosphates 85-104 thyrotropin releasing hormone Rattus norvegicus 27-30 2105370-3 1990 Pretreatment with 550 nmol TRH/l completely abolished the subsequent accumulation of inositol phosphates in response to 140 nmol TRH/l. Inositol Phosphates 85-104 thyrotropin releasing hormone Rattus norvegicus 129-132 2105370-4 1990 TRH-stimulated accumulation of inositol phosphates did not occur after pretreatment with 0.2 mumol phorbol ester/l. Inositol Phosphates 31-50 thyrotropin releasing hormone Rattus norvegicus 0-3 2848512-3 1988 Prolactin release is enhanced by vasoactive intestinal peptide (VIP), which increases cyclic AMP, and by thyrotropin-releasing hormone (TRH), which increases inositol phosphates (IPx). Inositol Phosphates 158-177 thyrotropin releasing hormone Rattus norvegicus 105-134 2839476-1 1988 The effect of dopamine, working through the activation of D2 receptors, on inositol phosphate production induced by thyrotropin-releasing hormone (TRH) was investigated in rat pituitary lactotroph cells. Inositol Phosphates 75-93 thyrotropin releasing hormone Rattus norvegicus 116-145 2839476-1 1988 The effect of dopamine, working through the activation of D2 receptors, on inositol phosphate production induced by thyrotropin-releasing hormone (TRH) was investigated in rat pituitary lactotroph cells. Inositol Phosphates 75-93 thyrotropin releasing hormone Rattus norvegicus 147-150