PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25549668-5	2015	In the neuronally derived A1A1 cell line, which expresses both IL-6 and 5-HT2A receptors, we found that IL-6 attenuates inositol phosphate (IP) accumulation in response to the 5-HT2 agonist, 2,5-dimethoxy-4-iodoamphetamine (DOI), suggesting that IL-6 can regulate 5-HT2A receptor function.	Inositol Phosphates	120-138	5-hydroxytryptamine receptor 2A	Homo sapiens	72-87	
25549668-5	2015	In the neuronally derived A1A1 cell line, which expresses both IL-6 and 5-HT2A receptors, we found that IL-6 attenuates inositol phosphate (IP) accumulation in response to the 5-HT2 agonist, 2,5-dimethoxy-4-iodoamphetamine (DOI), suggesting that IL-6 can regulate 5-HT2A receptor function.	Inositol Phosphates	140-142	5-hydroxytryptamine receptor 2A	Homo sapiens	72-87	
9928256-3	1998	Oleamide caused a potentiation of 5-HT-elicited inositol phosphate formation mediated by the 5-HT2A receptor, but inhibited the effects of 5-HT on cAMP production mediated by the 5-HT7 receptor.	Inositol Phosphates	48-66	5-hydroxytryptamine receptor 2A	Homo sapiens	93-108	
11602671-4	2001	For both receptor systems, pretreatment with 5-HT reduced the ability of a maximal concentration of 5-HT to stimulate phospholipase C-mediated inositol phosphate accumulation by about 65%, although the 5-HT2C receptor system was more sensitive to the desensitizing stimulus.	Inositol Phosphates	143-161	5-hydroxytryptamine receptor 2A	Homo sapiens	9-17	
9831908-5	1998	5-HT stimulated [3H]-inositol phosphate ([3H]-IPx) production at both the 5-HT2C (pEC50=8.03+/-0.15) and 5-HT2A receptors (pEC50=7.15+/-0.08), with maximal responses occurring after exposure to 1 microM and 10 microM 5-HT, respectively.	Inositol Phosphates	21-39	5-hydroxytryptamine receptor 2A	Homo sapiens	105-111	
9831908-17	1998	6 These results indicate that the human 5-HT2A and 5-HT2C receptors both exhibit desensitization at the level of inositol phosphate formation when expressed in the same cellular environment, with the 5-HT2C receptor being more sensitive to 5-HT-mediated desensitization than the 5-HT2A receptor.	Inositol Phosphates	113-131	5-hydroxytryptamine receptor 2A	Homo sapiens	40-52	
2166922-8	1990	Stimulation of the alpha 2-receptor did not induce accumulation of inositol phosphate but significantly potentiated 5-HT2-receptor transduction, as measured by hydrolysis of phosphoinositide and formation of inositol phosphate.	Inositol Phosphates	208-226	5-hydroxytryptamine receptor 2A	Homo sapiens	116-130	
2315313-4	1990	Pharmacological studies suggested that release of arachidonic acid and inositol phosphates was mediated by a type 2 5-HT (5-HT2) receptor.	Inositol Phosphates	71-90	5-hydroxytryptamine receptor 2A	Homo sapiens	122-137	
8190100-9	1994	In conclusion, these data suggest that 5-HT2A receptor activation can amplify cAMP formation in A1A1 cells by two distinct pathways coupled to the hydrolysis of inositol phosphates, i.e., PKC and calcium/calmodulin.	Inositol Phosphates	161-180	5-hydroxytryptamine receptor 2A	Homo sapiens	39-54	
2823165-2	1987	Ketanserin and ritanserin, selective antagonists for the central 5-HT2 receptor, inhibited the 5-HT-stimulated formation of inositol monophosphate.	Inositol Phosphates	124-146	5-hydroxytryptamine receptor 2A	Homo sapiens	65-79