PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9892139-3	1999	They belong to the AT1 subtype as shown by the inhibitory effect of AT1 antagonists on [125I]-Sar1, Ala8 AngII binding and on all of the biologic effects mediated by AngII, such as cytosolic calcium stimulation, inositol phosphate formation, prostaglandin production, and cell contraction.	Inositol Phosphates	212-230	angiotensin II receptor, type 1a	Rattus norvegicus	19-22	
10903964-2	2000	The role of different residues of the rat AT(1A) receptor in the interaction with the N- and C-terminal ends of angiotensin II (AngII) was studied by determining ligand binding and production of inositol phosphates (IP) in COS-7 cells transiently expressing the following AT(1A) mutants: T88H, Y92H, G196I, G196W and D278E.	Inositol Phosphates	216-218	angiotensin II receptor, type 1a	Rattus norvegicus	42-47	
9892139-3	1999	They belong to the AT1 subtype as shown by the inhibitory effect of AT1 antagonists on [125I]-Sar1, Ala8 AngII binding and on all of the biologic effects mediated by AngII, such as cytosolic calcium stimulation, inositol phosphate formation, prostaglandin production, and cell contraction.	Inositol Phosphates	212-230	angiotensin II receptor, type 1a	Rattus norvegicus	68-71	
9650856-3	1998	In monkey kidney cells expressing angiotensin AT1A or AT1B receptors, it stimulated inositol phosphate accumulation, but the maximal response was 34.9 and 23.3%, respectively, of those of angiotensin II.	Inositol Phosphates	84-102	angiotensin II receptor, type 1a	Rattus norvegicus	46-50	
8170471-9	1994	The release of total inositol phosphates in response to ET-1 and AII was concentration dependent and inhibited by the ETA receptor-selective antagonist BQ-123 and the AT1 receptor-selective antagonist losartan, respectively.	Inositol Phosphates	21-40	angiotensin II receptor, type 1a	Rattus norvegicus	167-170	
9097077-6	1997	PLC activity was coupled to an AT1 receptor in both medullary and cerebellar astrocytes, as demonstrated by the inhibition of Ang II-activation of inositol phosphate release by the AT1 antagonist losartan.	Inositol Phosphates	147-165	angiotensin II receptor, type 1a	Rattus norvegicus	31-34	
9097077-6	1997	PLC activity was coupled to an AT1 receptor in both medullary and cerebellar astrocytes, as demonstrated by the inhibition of Ang II-activation of inositol phosphate release by the AT1 antagonist losartan.	Inositol Phosphates	147-165	angiotensin II receptor, type 1a	Rattus norvegicus	181-184	
8469768-6	1993	AII (1 microM) treatment of CHO-AT1a cells caused an increase in inositol phosphates and intracellular calcium relative to basal levels.	Inositol Phosphates	65-84	angiotensin II receptor, type 1a	Rattus norvegicus	32-36	
17284329-3	2007	We have determined that the conserved S109Y substitution of the rat AT(1A) receptor eliminates its candesartan binding, without exerting any major effect on its angiotensin II and peptide angiotensin receptor antagonist binding, internalization kinetics, beta-arrestin binding, and potency or efficacy of the inositol phosphate response.	Inositol Phosphates	309-327	angiotensin II receptor, type 1a	Rattus norvegicus	68-73	
1338730-2	1992	In adrenal glomerulosa cells, more than 90% of the receptors were AT1 and there was a good correlation between the potencies of the antagonists to inhibit ligand binding, and AII-stimulated aldosterone production and inositol phosphate formation.	Inositol Phosphates	217-235	angiotensin II receptor, type 1a	Rattus norvegicus	66-69	
1632771-8	1992	Also, the two subtypes of Ang II receptors mediate opposite effects on PI hydrolysis: Ang II binding to AT1 receptors increases inositol phosphate production, while Ang II binding to AT2 receptors decreases inositol phosphate production.	Inositol Phosphates	128-146	angiotensin II receptor, type 1a	Rattus norvegicus	104-107	
1632771-8	1992	Also, the two subtypes of Ang II receptors mediate opposite effects on PI hydrolysis: Ang II binding to AT1 receptors increases inositol phosphate production, while Ang II binding to AT2 receptors decreases inositol phosphate production.	Inositol Phosphates	207-225	angiotensin II receptor, type 1a	Rattus norvegicus	104-107	
1554376-1	1992	The stimulatory effect of angiotensin II (AT) on the accumulation of inositol phosphates and on aldosterone production is abolished by the AT1 selective receptor antagonist DuP753 while PD123177, an AT2 antagonist, is ineffective.	Inositol Phosphates	69-88	angiotensin II receptor, type 1a	Rattus norvegicus	139-142	
15905421-5	2005	EGF-induced AT(1)-R phosphorylation was associated with a decrease in membrane-associated AT(1)-Rs and a reduced inositol phosphate response to Ang II.	Inositol Phosphates	113-131	angiotensin II receptor, type 1a	Rattus norvegicus	12-19