PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21145450-0	2010	Insulin signaling: inositol phosphates get into the Akt.	Inositol Phosphates	19-38	insulin	Homo sapiens	0-7	
33139672-5	2020	Evidence showed that inositol phosphates might enhance the browning of white adipocytes and directly improve insulin sensitivity through adipocytes.	Inositol Phosphates	21-40	insulin	Homo sapiens	109-116	
33139672-7	2020	Despite all recent advances, many aspects of the bioactivity of inositol phosphates are still not clear, especially their effects on insulin resistance and alteration of metabolism, so more research is needed.	Inositol Phosphates	64-83	insulin	Homo sapiens	133-140	
2158304-0	1990	Mannose, glucosamine and inositol monophosphate inhibit the effects of insulin on lipogenesis.	Inositol Phosphates	25-47	insulin	Homo sapiens	71-78	
15855345-4	2005	This inhibition of insulin secretion was paralleled by significant reductions in carbachol-potentiated inositol phosphate accumulation.	Inositol Phosphates	103-121	insulin	Homo sapiens	19-26	
9114007-0	1997	Inositol hexakisphosphate stimulates non-Ca2+-mediated and primes Ca2+-mediated exocytosis of insulin by activation of protein kinase C. D-myo-inositol 1,2,3,4,5,6-hexakisphosphate (InsP6), formed via complex pathways of inositol phosphate metabolism, composes the main bulk of inositol polyphosphates in the cell.	Inositol Phosphates	221-239	insulin	Homo sapiens	94-101	
1696549-1	1990	Inositol-phosphates, glucosamine and glucose-6-phosphate blocked the effects of insulin on target protein phosphorylation in adipocytes, but the unsubstituted or sulphated derivatives of inositol or of glucose, or N-acetyl-glucosamine were without effect.	Inositol Phosphates	0-19	insulin	Homo sapiens	80-87	
2158304-15	1990	We also found that the effect of insulin on lipogenesis was blocked by mannose, glucosamine and inositol monophosphate, whereas the insulin effects on 3-O-methylglucose, cyclic AMP and lipolysis were unaffected.	Inositol Phosphates	96-118	insulin	Homo sapiens	33-40	
2158304-20	1990	(3) The observation that mannose, inositol monophosphate and glucosamine block the action of insulin of on lipogenesis supports a role of mannose- and glucosamine-containing IP-oligosaccharides as second messengers for this insulin effect.	Inositol Phosphates	34-56	insulin	Homo sapiens	93-100	
2158304-20	1990	(3) The observation that mannose, inositol monophosphate and glucosamine block the action of insulin of on lipogenesis supports a role of mannose- and glucosamine-containing IP-oligosaccharides as second messengers for this insulin effect.	Inositol Phosphates	34-56	insulin	Homo sapiens	224-231	
8652127-5	1996	After stimulation of mammalian cells by insulin or growth factors, the allosteric activation of eIF-2B activity by sugar phosphates and inositol phosphates may also provide an important parameter in the regulation of protein synthesis.	Inositol Phosphates	136-155	insulin	Homo sapiens	40-47	
3346337-1	1988	Mitogenic stimulation of quiescent human fibroblasts (HSWP) with serum or a mixture of growth factors (consisting of vasopressin, bradykinin, EGF, and insulin) stimulates the release of inositol phosphates, mobilization of intracellular Ca, activation of Na/H exchange and subsequent incorporation of [3H]-thymidine.	Inositol Phosphates	186-205	insulin	Homo sapiens	151-158	
2803236-5	1989	We found that inositol phosphate (IP)-oligosaccharides isolated from the drug Actovegin, as well as the alkaloid vinblastine, show a partial insulin-like effect on glucose-transport activity of fat-cells (3-O-methylglucose uptake, expressed as % of equilibrium value per 4 s: basal 5.8%, insulin 59%, IP-oligosaccharides 30%, vinblastine 29%) without inducing carrier translocation.	Inositol Phosphates	14-32	insulin	Homo sapiens	141-148	
2803236-5	1989	We found that inositol phosphate (IP)-oligosaccharides isolated from the drug Actovegin, as well as the alkaloid vinblastine, show a partial insulin-like effect on glucose-transport activity of fat-cells (3-O-methylglucose uptake, expressed as % of equilibrium value per 4 s: basal 5.8%, insulin 59%, IP-oligosaccharides 30%, vinblastine 29%) without inducing carrier translocation.	Inositol Phosphates	14-32	insulin	Homo sapiens	288-295	
2993299-9	1985	Pretreatment of the cells with insulin enhanced the effect of phenylephrine on inositol phosphates" accumulation, suggesting that insulin may potentiate phenylephrine-mediated phosphoinositide turnover.	Inositol Phosphates	79-98	insulin	Homo sapiens	31-38	
2993299-9	1985	Pretreatment of the cells with insulin enhanced the effect of phenylephrine on inositol phosphates" accumulation, suggesting that insulin may potentiate phenylephrine-mediated phosphoinositide turnover.	Inositol Phosphates	79-98	insulin	Homo sapiens	130-137